Stillbirth remains a major problem in both developing and developed countries. Omics evaluation of stillbirth has been highlighted as a top research priority. To identify new putative first-trimester biomarkers in maternal serum for stillbirth prediction using metabolomics-based approach. Targeted, nuclear magnetic resonance (NMR) and mass spectrometry (MS), and untargeted liquid chromatography-MS (LC-MS) metabolomic analyses were performed on first-trimester maternal serum obtained from 60 cases that subsequently had a stillbirth and 120 matched controls. Metabolites by themselves or in combination with clinical factors were used to develop logistic regression models for stillbirth prediction. Prediction of stillbirths overall, early (<28 weeks and <32 weeks), those related to growth restriction/placental disorder, and unexplained stillbirths were evaluated. Targeted metabolites including glycine, acetic acid, L-carnitine, creatine, lysoPCaC18:1, PCaeC34:3, and PCaeC44:4 pred...

Conditions of Possibility of a Perceived Formal Rhetoric. Musical form has been considered by composers and music theorists, at least since the end of the XVIIIth century, as a main aspect of musical composition. Some theoretical views of musical forms, even its perceptive reality, are challenged by music psychologists. However, other data suggest that a representation in memory of large-scale structures is possible. This article proposes to assess, through a review of the form theories and the experimental psychology literature, two fundamental questions on the perception of form : Which musical dimensions and types of representation in memory support the perception of form ? We propose a new conception of musical form which able to include, with Western tonal musical architectures, some other expressions of musical form.

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In this paper, four three-node triangular finite element models which can readily be incorporated into the standard finite element program framework are devised via a multi-field variational functional for the bounded plane Helmholtz problem. In the models, boundary and domain fields are independently assumed. The former is constructed by nodal interpolation and the latter comprises nonsingular solutions of the Helmholtz equation. The equality of the two fields are enforced along the element boundary. Among the four devised models, the most accurate one is 1/3 to 1/2 less erroneous than the conventional single-field model in most examples.

Evaluar la navegación de agentes reactivos en entornos discretos rectangulares tiene una complejidad heterogénea, y el éxito de esta tarea depende tanto del diseño del agente como de la topología del entorno. Se explora el problema modelando agentes con máquinas de estados finitos con entradas y acciones disponibles mínimas. La navegación se parametriza respecto del tamaño del entorno y de la distancia entre el comienzo y la meta a alcanzar. Se caracterizó un generador aleatorio de entornos que fueron usados para testear agentes típicos. Como resultado, los modelos más exitosos siguen un comportamiento esperable, el de rodear obstáculos indefinidamente.