This research focuses on developing an Android-based mobile application to facilitate the process of learning to write in Japanese for beginners. This application is designed to effectively teach the two main Japanese writing systems, namely Hiragana and Katakana, through an interactive and easy-to-follow method. By utilizing digital image processing technology, handwriting pattern recognition is carried out in real time by applying the Local Binary Patterns (LBP) and Euclidean distance methods. The app provides instant feedback allowing users to correct their mistakes in real-time. This research describes the application development process, the methodology used, and evaluation of application performance based on user testing. The research results show that this application is effective in improving Japanese writing skills for beginners, as well as offering a flexible and accessible way to learn Japanese. This study provides valuable insights into language learning applications that can be adapted to various learners needs and offers recommendations for the future development of similar applications.

Resumen El presente articulo tiene como proposito documen-tar la comprension de los deseos a partir de dos aproximaciones: situaciones que utilizan el humor grafico y situaciones clasicas de preferencias con ni-nos entre 2.8 y 3 anos. Se trabaja con el metodo mi-crogenetico combinado con un estudio en series de tiempo durante 10 sesiones de aplicacion (dos meses y medio). Se realizan dos tipos de analisis, uno in-tragrupo y uno intraindividual que permite capturar los diversos caminos por los cuales transitan los ninos al enfrentarse a las tareas. Los resultados arrojan la identificacion de tres tendencias en los desempenos: estable, descendente y ascendente. Igualmente, se pone en evidencia la importancia de trabajar otras vias para el estudio de los procesos cognitivos en ter -minos metodologicos y se confirma el humor grafi-co como alternativa para el estudio de los estados mentales. Palabras clave: Humor, incongruencia, teoria de la mente, preferencias, comprension de deseos. * ...

Colorectal cancer (CRC) is the third most deadly cancer worldwide, and inflammatory bowel disease (IBD) is one of the critical factors in CRC carcinogenesis. IBD is responsible for an unphysiological and sustained chronic inflammation environment favoring the transformation. MicroRNAs (miRNAs) belong to a class of highly conserved short single-stranded segments (18–25 nucleotides) non-coding RNA and have been extensively discussed in both CRC and IBD. However, the role of miRNAs in the development of colitis-associated CRC (CAC) is less clear. The aim of this review is to summarize the major upregulated (miR-18a, miR-19a, miR-21, miR-31, miR-155 and miR-214) and downregulated (miR-124, miR-193a-3p and miR-139-5p) miRNAs in CAC, and their roles in genes’ expression modulation in chronic colonic-inflammation-induced carcinogenesis, including programmed cell-death pathways. These miRNAs dysregulation could be applied for early CAC diagnosis, to predict therapy efficacy and for precisio...

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Los estudios regionales del ERCE 2019 sustentan los resultados investigativos de los autores acerca de la necesidad de replantear las fórmulas educativas para contribuir a una formación y desarrollo de valores y la esfera emocional, en cuyo camino la lectura y de manera particular la lectura literaria, constituye punto de partida para generar vivencias y relaciones de sentir y pensar para el desarrollo humano. El proceso de investigación centrado en la educación literaria ofrece a la didáctica del lenguaje alternativas para perfeccionar y mejorar la presencia de la literatura en la educación, se ofrecen los referentes teórico- metodológicos partir del empleo de métodos de investigación y didácticos específicos del lenguaje.