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Expert Opinion on Drug Safety
Minimizing chemotherapy-induced peripheral neuropathy: preclinical and clinical development of new perspectives2015 •
Chemotherapy-induced peripheral neuropathies (CIPN) are a dose-limiting adverse effect of certain anticancer drugs (platinum salts, vinca alkaloids, taxanes, bortezomib, thalidomide, epothilones, eribulin). CIPN are mainly responsible for sensory disturbances and are associated with a decrease in quality of life. After the end of chemotherapy, CIPN can last for several months and even years. Unfortunately, recent meta-analyses of clinical trials have demonstrated that there is no univocal gold standard for the prevention and treatment of CIPN. Areas covered: Using animal models of CIPN, several new strategies to prevent or treat CIPN are under development. These new strategies involve several pathways, including ion channels, neuroprotectants, glutamatergic neurotransmission, oxidative stress, cannabinoid system, inflammation, and mitochondrial functions. Expert opinion: To date, based on meta-analyses of clinical trials, no drug can be proposed as a gold standard to prevent or treat CIPN. Consequently, there is a strong discrepancy between the optimistic results of animal studies and the poor outcomes of clinical trials. Pain assessment in preclinical and clinical studies is probably not the best outcome measurement tool and all these studies should include composite outcomes including the full complexity of CIPN symptoms, such as positive symptoms (pain, paresthesia, and dysesthesia) and negative ones (numbness).
The Open Anesthesiology Journal
Sciatic Nerve Block in the Popliteal Fossa Using Lateral Approach in an Infant with Goldenhar Syndrome2013 •
Goldenhar syndrome is a rare disorder characterized by a wide range of congenital malformations that may cause difficulty in tracheal intubation and mask ventilation. We describe a case of a male infant with Goldenhar syndrome successfully treated with general anesthesia with laryngeal airway mask and peripheral nerve block for club foot disease surgery.
Journal of Physics: Conference Series
Credit scoring analysis using pseudo nearest neighbor2019 •
Credit scoring is one of the crucial task and a core responsibility for financial institutions in their risk management. This study aims to apply the pseudo nearest neighbour (PNN) method as a tool to identify which prospective borrowers are eligible for their loan proposals. If a new borrower has characteristics closer to a good historical borrower then the loan proposal is worthy to approval. But if not, the proposed loan will be refused. The historical data in this paper are credit data from a national bank in Indonesia. The characteristics of historical debtors consist of age, amount of a child, length time of business, income, loans amount, and the period of credit. The best classification of k-NN is using k = 1, because it makes the smallest error 1,89%. While the best classification of PNN is using k = 13 with the smallest error 20,75%. Based on total accuracy of classification shows that the credit classification of debtors using k-NN is more appropriate than PNN.
2006 •
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2006 International Conference of the IEEE Engineering in Medicine and Biology Society
Application Parameters Optimization to Guarantee QoS in e-Health Services2006 •
Science of The Total Environment
Persistent organic pollutants (POPs) and metals in primiparous women: a comparison from Canada and Mexico2014 •
International Journal of Geriatric Psychiatry
The health and social needs of older male prisoners2012 •
2014 •
Resumo: O autor reconhece que o tema e fascinante, mas dificil de ser abordado, por causa de fantasmas ou mesmo tabus que tentam direcionar ideologicamente a reflexao sobre “Igreja e Eucaristia”. Ele comeca verificando esse tema nos documentos do Vaticano II e nas numerosas intervencoes do Magisterio no pos-Concilio. A seguir, estuda a relacao entre Ecaristia e Igreja a partir da Prece Eucaristica V, aprovada para o Brasil em 1975. Chama a atencao para o significado do “primeiro nome da Missa”, a “fracao do pao”, e para a unidade de toda a Liturgia Eucaristica. Antes da conclusao, alerta para os desafios que permanecem. Abstract: The author realizes that the theme is fascinating but quite difficult to be dealt with due to possible phantoms or even taboos which might steer forcibly the theological thought pattern concerning the “Church and Eucharist”. He begins by verifying this theme in the documents of Vatican II and in the numerous interventions of the Magisterium during the perio...
2009 •
Hydrobiologia
Allometric models for aboveground biomass estimation of the mangrove Avicennia schaueriana2014 •
East African Medical Journal
Determinants of pneumococcal conjugate vaccine uptake among children attending immunisation services at Kenyatta National Hospital, Nairobi, Kenya2016 •
2013 •
International Journal of Community Well-Being
A holistic approach to campus well-being: Steps to Leaps at Purdue University2021 •
Journal of anatolian environmental and animal sciences
Anadolu Mandası Dışkılarından İzole Edilen Termofilik Campylobacter Türlerinin Moleküler Karakterizasyonu2020 •
2017 •
IEEE ATM '97 Workshop Proceedings (Cat. No.97TH8316)
A simple ABR switch algorithm for the weighted max-min fairness policy2019 54th International Universities Power Engineering Conference (UPEC)
Overview of the Clustering Algorithms for the Formation of the Bidding Zones2019 •