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Human liver

Tìm thấy 12+ kết quả cho từ khóa "Human liver"

In vitro effects of pesticide exposure on the activity of the paraoxonase-1 enzyme from sheep liver microsomes

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One study examined the effects of EDTA, Mg 2. p-hydroxymercuribenzoate (p-OH-MB), and phenyl mercuric acetate (PMA) on paraoxonase activity from human liver microsomes. competitive inhibitors, Zn was noncompetitive, and the results were mixed for Hg.

New insights from Opisthorchis felineus genome: Update on genomics of the epidemiologically important liver flukes

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The draft genome of the carcinogenic human liver fluke Clonorchis sinensis. The carcinogenic liver fluke, Clonorchis sinensis: new assembly, reannotation and analysis of the genome and characterization of tissue transcriptomes. Whole transcriptome profiling of adult and infective stages of the trematode Opisthorchis felineus. A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni.

The whole transcriptome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice

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Transcriptomics was carried out on human liver biopsies (GSE hepatocyte humanized livers, primary human hepatocytes (GSE and human precision-cut liver slices (GSE . a Scatter plot analysis of normalized expression values comparing the whole genome expression profile of the human liver biopsies (x-axis) with the whole genome expression profile of the hepatocyte humanized livers (left panel), human precision-cut liver slices (middle panel), and human primary hepatocytes (right panel) (all y-axis).

Single-cell RNA-Seq analysis reveals dynamic trajectories during mouse liver development

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For liver re- search, the gene expression profiles of zonation and spatial division of hepatic lobule in adult mouse liver were revealed at single-cell resolution [16], and multi- lineage communication is also shown to be important for human liver bud development [17].

Purification and characterization of NADPH-cytochrome P450 reductase from Lake Van fish liver microsomes and investigation of some chemical and metals’ effects on the enzyme activity

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Functional and structural properties of mammalian cytochrome P450 reductase, which was purified from bovine liver, 7 guinea pig liver, 14 pig liver, 15,16 sheep liver and lung, 17,18 human liver, 19 human placental microsomes, 20 human neutrophil membranes, 21 human brain, 22 rat liver, 23,24 and rat brain 25 microsomes, were examined in detail and some of their kinetics and structural and functional differences were determined..

Purification, refolding, and characterization of recombinant human paraoxonase-1

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In the present work, hPON1 was cloned from Human Liver Marathon-Ready cDNA and expressed in E.. Furthermore, some kinetic properties of the recombinant hPON1 were also determined.. Expression of rhPON1. After amplification of the hPON1 gene from the human fetal liver cDNA library by PCR, obtained fragments were transferred into the pET-SUMO vector with T4 DNA-ligase as described in the Experimental section. precipitation did not affect enzyme activity, it is not shown in the purification table.

Recent advances in organ-on-a-chip technologies and future challenges: A review

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The liver is located on the right side of the abdomen with two large sections, or lobes, at the right and the left, as illustrated in Figure 12. 40 The lobule and the acinus are important functional units for the structural organization of the human liver. General representation of the human liver and its parts (reprinted with permission from the editors of Encyclopædia Britannica.

MKL1 regulates hepatocellular carcinoma cell proliferation, migration and apoptosis via the COMPASS complex and NF-κB signaling

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By searching against the Oncomine database, we showed that the expression of MKL1 gene in cancerous tissues collected from HCC patients were significantly elevated compared with the normal human liver tissues (Fig. Also, the Oncomine data- base showed that the expression of MKL1 gene in HCC patients were even higher than those patients diagnosed with liver cirrhosis and liver cell dysplasia, which were all significantly higher than normal human live tissues (Fig.

Functional module detection through integration of single-cell RNA sequencing data with protein–protein interaction networks

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Resolving the fibrotic niche of human liver cirrhosis at single-cell level. Spatial reconstruction of single-cell gene expression data

Transcriptomic analysis of marine endophytic fungi extract identifies highly enriched anti-fungal fractions targeting cancer pathways in HepG2 cell lines

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1 West African Center for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana Full list of author information is available at the end of the article Blessie et al. cerevisiae alone or both and reduced proliferation of the human liver cancer cell line HepG2 implicating regulation of several cancer- and metabolism-related pathways.

Transposable elements generate regulatory novelty in a tissue-specific fashion

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For example, HERV15 (LTR) is significantly more enriched in the liver and in the stomach mucosa compared to any other tissue (Fig. Notably, HERV15 was recovered as signifi- cantly enriched in the human liver enhancers also in our previous study [33], suggesting that the findings of the present analysis are not likely to represent batch-specific ef- fects of the Roadmap data..

Flavonoids and their cytotoxic activity from Tithonia diversifolia

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Four human cancer cell lines including KB (mouth epidermal carcinoma cells), HepG2 (human liver hepatocellular carcinoma cells), Lu1 (human lung adenocarcinoma cells), and MCF7 (human breast cancer cells). The IC 50 value wasdetermined as the concentration of compound that inhibits 50% cell growth compared to the control. 1 H-NMR spectrum of 1, appeared a pair of two doublets at δ 7.83 (H- 2'/H-6') and 6.93 (H-3'/H-5') of four aromatic protons with ortho coupling constant (J = 9.0Hz).

Protein acetylation in mitochondria plays critical functions in the pathogenesis of fatty liver disease

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Furthermore, this study identified potential important proteins, such as HADHA, ACAT1, and EHHADH, which may be important regulatory factors through modification of acetylation in the development of fatty liver disease in dairy cows and possible therapeutic targets for NAFLD in human beings..

Transcriptomic analysis between Normal and high-intake feeding geese provides insight into adipose deposition and susceptibility to fatty liver in migratory birds

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Research has demonstrated that the formation of goose fatty liver shares similar pheno- typic changes with human non-alcoholic fatty liver, but differs in pathological development because goose fatty liver only shows a low level of inflammation and other immune responses [7, 9, 10]. This distinct difference in the phenotype indicates that goose fatty liver might be- come a resource for better understanding lipid depos- ition in birds and for human fatty liver research..

Integrative analysis of transcriptomic data related to the liver of laying hens: From physiological basics to newly identified functions

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Remarkably, all these proteins are highly overexpressed in the liver of laying hens while they lack expression (or ex- hibit a very low expression) in the liver of human species (Additional file 2, column G)..

Investigation of the effects of some water-soluble vitamins on glutathione reductase enzyme purified from bovine liver

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Although the GR enzyme was not purified from bovine liver for the first time here, the reaction and reaction products of GR and also the mechanism in which it is involved are very important. Therefore, in this study, we investigated the effect of some water-soluble vitamins on this enzyme. Effects of some antibiotics on enzyme activity of glucose-6- phosphate dehydrogenase from human erythrocytes. doi: 10.1006/. Glutathione reductase in wheat grain.

About the existence of common determinants of gene expression in the porcine liver and skeletal muscle

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The profiles of mRNA expression of the porcine liver and skeletal muscle are highly divergent. In the liver, we detected a. Table 1 List of the genome-wide significant cis-eQTLs detected in the gluteus medius (GM) muscle (those that have been consistently detected in the liver are shown in bold) 1. Identification of cis -eQTLs with consistent effects on the mRNA levels of genes expressed in the liver and skeletal muscle.

The effect of banana peels supplemented diet on acute liver failure rats

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RS has attracted interest because of its positive effects in the human Table 4 Relative organs weight of acute liver failure rats fed on banana peels supplemented diet..

Proteome analysis identified proteins associated with mitochondrial function and inflammation activation crucially regulating the pathogenesis of fatty liver disease

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Expectantly, understanding the molecular mechanisms of the pathogenesis of fatty liver disease in dairies, as an animal model of non-alcoholic fatty liver disease (NAFLD) in human beings, which is a clinico-pathologically defined process associated with metabolic syndrome, could inspire and facilitate the development of efficacious therapeutic drugs on NAFLD..

Disseminated intravascular coagulation following air embolism during orthotropic liver transplantation: Is this just a coincidence?

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The first human orthotopic liver transplantation (OLT) was performed in 1963. Despite the development of technology in the medical field, hepatic transplantation remains a difficult surgery and carries a risk of signifi- cant complications [1]. One possible, although rare, but potentially fatal complication that occurs during ortho- topic liver transplantation is venous air embolism (VAE)..