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Pharmaceutical Substances Syntheses, Patents, Applications - Part 100

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J-prior 7.7.1994).. RN MF: C,H4C1,NNa04S MW: 292.07 EINECS: 227-176-3. 4 mg Trade Name(s):. Use: glucocorticoid RN MF: C24H32ClFOS MW: 454.97 EINECS: 221-439-6. 0.1 % Trade Name(s):. ATC: POlBXOl Use: antimalarial RN MF: C2,H,,C1,F,N0 MW: 500.43 EINECS: 274-104-1. RN MF: C2,H,,Cl2F,NO . RN MF: C,,H,,C12F,N0 MW enantiomer. RN MF: C26H,oCI,F?N0 MW: 500.43. RN MF: C,2H27C1F,0, MW: 444.90 EINECS: 256-664-9. Trade Name(s):....

Pharmaceutical Substances Syntheses, Patents, Applications - Part 101

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Use: anticoagulant, antithrombotic RN MF: [C,,H,,N,O,sS,]x MW: unspecified EINECS: 232-681-7. 500 mglkg (M, i.v.);. RN MF: unspecified MW: unspecified LD,: 2800 mgikg (M, i.v. RN MF: unspecified LD. RN MF: unspecified. Use: vasodilator RN MF: C2,H3,N,06 MW: 505.57. 180 mglkg (M, i.v. >800 mglkg (M, p.0.);. 1250 mgikg (M, i.p.) CN: 6-amino-2-methyl-2-heptanol hydmchloride. 900 mglkg (M, i.p.). Use: antibiotic RN...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 102

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Trade Name(s):. Use: bronchodilator RN MF: C22H32N20, MW: 420.51. RN MF: C,,H,,N,O, .2HCI MW: 493.43 EINECS LD,: 88 m g k g (M, i.v. 2036 mglkg (M, p.0.);. 58 mglkg (R, i.v. 10 glkg (R, p.0.) sulfate. RN MF: C22H,2N,0,.xH2S0, MW: unspecified EINECS: 250-057-2. 23 mglkg (M, i.v. 1080 mglkg (M, p.0.). US Sharp &. USA: Cyclaine (Merck Sharp &....

Pharmaceutical Substances Syntheses, Patents, Applications - Part 103

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Hydracort (Galderma) numerous gcnerics and combination preparations. Dohme) several combination preparations 1: Algicortis (Vaillant). several combination preparations J: Cortril (Taito Plizer). Dohme) Hy tone (Dermik) Protocort (Monarch) several combination preparations. numerous combination preparations and generics Colofoam (Norgine Pharma). numerous combination preparations and generics Actinac (Hoechst)-comb.. numerous combination. 746 mglkg (M, i.v. generic and numerous combination preparations. GB: Cobalin-H (Link) Neo-Cytamen...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 104

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950 mglkg (R, p.0.) pamoate. 11.8.1959. 3850 mg/kg (R, p.0.) CN: 7-hydroxy-4-methyl-2H-I -benzopyran-2-one. 2.12.1992).. 28.7.1977. 6.12.1 988. 12.3.1985. 11.1.1966. 25.5.1976. 25.11.1966. 20.5.1977. 16.6.1976).. 5.1 1.1968 and 15.11.1968. 29.4.1977. 17.3.1977).. 11.4.1974).. 12.2.1976. 16.10.1976. 26.12.1978. 27.12.1976. 16.6.1977).

Pharmaceutical Substances Syntheses, Patents, Applications - Part 105

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Use: anti-inflammatory, analgesic RN MF: C,3H1802~C6H14N202 MW: 352.48 EINECS: 260-751-7. 22.4.1974. 22.3.1974).. Use: anti-inflammatory RN MF: C13H,,N02 MW: 221.30 EINECS: 258-683-8. ATC: COIBDO5 Use: antiarrhythmic RN MF: C20H36N,0,S . RN MF: C,,,H,,N203S MW: 384.59. Use: antineoplastic, anthracycline RN MF: C2,Hl7NO, MW: 497.50. 6.12.1974).. D: Zavedos (Pharmacia &. coenzyme Q10 derivative, nootropic RN MF: C,,H,,O, MW: 338.44. 4 glkg (R, i.p.)...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 106

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Use: antihypertensive (ACE inhibitor) RN MF: C,,,H2,N30, MW: 405.45. RN MF: C,,H,,N,O. 12.12.1989. 10.12.1987. 8.12.1987. 9.12.1986).. Use: p-lactam antibiotic RN MF: C,,HI,N,04S MW: 299.35 EINECS: 264-734-5. RN MF: C,,H,,N,04S . RN MF: C,,H,,N, MW: 240.31. RN MF: C,,HI,N4 . Use: coronary vasodilator, antianginal RN MF: C,,H,,N,O MW: 260.34 EINECS . RN MF: C,,H,N,O . Use: antineoplastic RN MF: CRH19N0,S2 MW:...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 107

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Use: vasoconstrictor, nasal decongestant RN MF: Cl,H15N3 MW: 201.27. RN MF: C,,H,,N3 . Use: appetite depressant RN MF: C,,H,,IVO MW: 191.27. RN MF: C,,H,,NO. Use: diuretic, antihypertensive RN MF: Cl,HI,CIN,O,S MW: 365.84 EINECS: 248-012-7. Use: cardiac depressant (class I antiarrhythmic), therapy of life- threatening ventricular arrhythmias RN MF: C2,H2,N20 MW: 308.43. RN MF: C20H24N20. RN MF: C,,H,,NO, MW: 231.30 CN:...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 108

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a WO Merck &. 3.11.1992. b WO Merck &. 11.7.1994. WO Merck &. e WO Merck &. 25.10.1996. f US Merck &. 8.11.1991).. g WO Merck &. 11.3.1996. 15.3.1995).. aa WO Merck &. 14.5.1996. 18.5.1995).. 30.1.1995. ab GB Merck &. 20.6.1996. 13.2.1996. 28.6.1995).. ba WO Merck &. 15.5.1996. 19.5.1995).. US Merck &. bb WO Merck &. 17.10.1995. 15.3.1995. 14.1 1.1994....

Pharmaceutical Substances Syntheses, Patents, Applications - Part 109

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Use: X-ray contrast medium RN: 440-58-4 MF: C12H,,13N204 MW: 627.94 EINECS: 207-125-1. RN MF: C,,H,,13N204 . Use: X-ray contrast medium (cholangiography) RN MF: C26H2,1,N20,0 MW: 1287.92 EINECS: 250-478-1. RN MF: C2,H2,16N20,0. Use: X-ray contrast medium (myelography) RN: 99-79-6 MF: C,,H,,I02 MW: 416.34 EINECS: 202-787-8. Trade Name(s):. Use: X-ray contrast medium RN MF: C,,H,oI,N207 MW: 1127.71 EINECS: 220-048-8. RN MF: CI,H,,I,N,07~...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 110

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Use: X-ray contrast medium RN MF: Cz4H2,1,N,0n MW: 1268.88 EINECS: 261-560-1. RN MF: CZ4H2,I,N,NaOn MW: 1290.87 EINECS meglumine salt. RN MF: C24H2,1,N,0n . 20.5.1975. Use: X-ray contrast medium RN MF: C,,HIII3N2O, MW: 643.94 EINECS: 248-887-5. R03BB01 Use: bronchodilator RN MF: C,,H,&rNO, MW: 41 2.37 EINECS: 244-873-8. 12.29 mglkg (M, i.v. 1001 mglkg (M, p.0.);. 15.7 mg/kg (R, i.v. 1975) Ing.)-comb....

Pharmaceutical Substances Syntheses, Patents, Applications - Part 111

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2 mglkg (M, p.0.);. RN MF: C,HlyN. 18 mglkg (M, i.v.);. RN MF: C,H,,N . 130 mglkg (R, i.p.). 149 mglkg (M, i.v. R03CBOI Use: bronchodilator, dermatic RN MF: C, ,H,,NO, MW: 21 1.26 EINECS . 1260 mglkg (M, p.0.);. 26.9 mglkg (R, i.v. 2221 mglkg (R, p.0.);. 188 mglkg (M, i.v. 96 mglkg (R, i.v. >40 mglkg (M, i.v....

Pharmaceutical Substances Syntheses, Patents, Applications - Part 112

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Trade Name(s):. 48 mglkg (M, i.v. 200 mglkg (M, p.0.). 1.2 mglkg (M, i.v. 1.8 mglkg (R, i.v. RN MF: C2,H1,N,04. 190.6 mglkg (M, i.v.). RN MF: C,,,H2,N204 MW: 358.44. 46.4 mglkg (M, i.v. r 3 2 0 mglkg (M, p.0.);. 1 % Trade Name(s):. RN MF: C,nH,,N4011 . 1130 mglkg (M, p.0.)

Pharmaceutical Substances Syntheses, Patents, Applications - Part 113

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Use: analgesic, anesthetic RN MF: C,3H,,C1N0 MW: 237.73 EINECS: 229-804-1. RN MF: C,3H,,CIN0. Use: antihypertensive RN MF: C,,H,,FN303 MW: 395.43 EINECS: 277-680-2. Use: tranquilizer RN MF: C,,H,,CIN,O, MW: 368.82 EINECS LD. RN MF: C,,H2,N02 . 31.1.1977).. Use: analgesic, anti-inflammatory RN MF: C,,H,,O, MW: 254.29 EINECS: 244-759-8. 62.4 mglkg (R, p.0.) CN: 3-benzoyl-a-methylbenzeneacetic acid lysine saIt. RN MF: Cz2Hz8NzOs MW. 16.10.1976....

Pharmaceutical Substances Syntheses, Patents, Applications - Part 114

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RN MF: C,,H2,N203 MW: 328.41 EINECS LD. RN MF: C,yH24N20. 22.9.1967. 5.12.1972. antihypertensive RN MF: C,,H,,NO, MW: 455.55. 22.8.1985. 22.8.1984. 13.2.1991).. 21.12.1987. 26.7.1987).. 26.9.1994. ATC: A06ADI 1 Use: laxative RN MF: C,2H22011 MW: 342.30 EINECS CN: 4-0-P-D-galactopyranosyl-D-fructose. 8.12.1970. 31.7.1970. 26.3.1991. 1.12.1987).. 12.10.1973. RN MF: CmH,lN303S MW: 229.26. RN MF: CmH,lN303S MW: 229.26 racemate. RN MF: CmH,,N303S MW: 229.26. 14.1 1.1991....

Pharmaceutical Substances Syntheses, Patents, Applications - Part 115

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ATC: DO1 Use: antifungal RN MF: C,4H,,CIN,S, MW: 319.84. RN MF: C16H,4F,N30,S MW: 369.37 LD. Use: p-lactam antibiotic (I-oxadethia- cephalosporin derivative) RN MF: C2nHmN609S MW: 520.48 EINECS: 265-287-9. RN MF: C,oH,8N,Na,0,S MW: 564.44 EINECS LDSO: 5300 mgkg (M, i.v. Use: antiglaucoma, prostaglandin RN MF: C,,H,O, MW: 432.60. Use: antirheumatic, immunosuppressant RN MF: C,,H9F,N202 MW: 270.2 1. Use: antibacterial, semisynthetic P-lactam...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 116

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17.7.1972).. 17.7.1973. Use: treatment of hypertension, vasoselective calcium antagonist RN MF: C&,N306 - HCI MW: 648.20. RN MF: C3,H4,N306 MW: 61 1.74. Use: mucoly tic agent RN MF: C,oH,7N04S2 MW: 279.38 EINECS: 258-879-3. 22.3.1973).. RN MF: CI7H,,N, MW. 17.4.1991).. RN MF: CllHI2N2S MW: 204.30 EINECS LD. RN MF: CIIH12N2S . RN MF: C,,H,,N,S MW: 204.30 EINECS CN tetrahydro-6-phcnylimidazo[2,l-b]thiazole. RN MF:...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 117

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28.5.1970).. et al.: Helv. 23.12.1969. 28.10.1970. 10.5.1971. 9.12.1971. et al.: Chem. 8.10.1968. 14.8.1970. 21.10.1971. combination with carbidopa:. 30.10.1973. 26.12.1978. with carbidopa. (?)-ethyl 9.10-difluoro- 3-hydroxymethyl dihydro-7H-pyrido- [I ,2.3-de]-1.4-benzoxozine 6-corboxylote (V). (-)-ethyl 9.1 O-difluoro- 3-hydroxymethyl dihydro-7H-pyrido- [1.2.3-de]-1.4-benzoxo- zine-6-corboxylote (VII). 7-0x0-2.3-dihydro-7H-pyrido- (S)-9.10-difluoro-3-methyl- [I .2.3-de]-1.4-benzoxazine-6- corboxylic acid (M). 11.10.1980. 10.12.1985. 11.12.1990. 31.10.1968

Pharmaceutical Substances Syntheses, Patents, Applications - Part 118

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150 mglkg (R, p.0.) CN: 17-methylmorphinan-3-01 tartrate (1:l). 0.025 mg, 0.05 mg, 0.075 mg, 0.1 mg, 0.125 mg, 0.150 mg, 0.175 mg, 0.2 mg, 0.3 mg (as sodium salt). Usc: coronary vasodilator RN MF: C3,H3,F2N3O MW: 491.63 EINECS . Use: thyroid hormone RN MF: C,SH,213N04 MW: 650.98 EINECS: 229-999-3. 0.005 mg, 0.02 mg, 0.025 mg, 0.05 mg, 0. RN MF:...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 119

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12.7.1967. 12.7.1967). inhibitor RN MF: C,,H19F2N303 MW: 351.35. 246 mg/kg (M, i.v. 3800 mg/kg (R, p.0.). RN MF: C,,HlyF2N3O3 . 253 mg/kg (M, i.v. 1608 mg/kg (M, p.0.);. 328 mg/kg (R, i.v. 25.10.1988. 20.5.1987. 14.1.1987).. 13.5.1987. 28.12.1988. Use: vasodilator (peripheral) RN MF: C13H1XN403 MW: 278.31 EINECS: 233-547-0. ATC: LOlAD02 Use: antineoplastic RN MF: C,HI,CIN30, MW: 233.70 EINECS LD. RN MF:...