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Pharmaceutical Substances Syntheses, Patents, Applications - Part 120

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0.5 mg, 1 mg, 2 mg Trade Name(s):. 2 mg, 8 mg Trade Name(s):. et al.: J. et al.: Bioorg. 20.9.1990. 20.9.1990).. 20.3.1992).. 10.7.1980).. Hirschmann et al.: Chem. 23.1.1980).. 13.6.1980. et al.: Proc. et al.: Novel Microb. 20.2.1980. 20.2.1979).. 25.7.1980. 19.2.1980).. et al.: Synform (SNFMDF review).. et al.: Tetrahedron Lett. 20.2.1998. 20.2.1997).. RN MF: C,,H,,CIN,O. 17.7.1979

Pharmaceutical Substances Syntheses, Patents, Applications - Part 121

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Use: topical anti-inflammatory RN MF: C,,H2,NO2 MW: 249.35 EINECS: 280-048-9. Use: bronchodilator RN MF: C,,H18CIF3N20 MW: 3 10.75. RN MF: C7HION202S . RN MF: C7H,,N20,S . Use: antacid RN MF: A15H,,Mg,o0,,S2 . Malotilate Use: liver therapeutic, hepatoprotectant RN MF: C12H1604S2 MW: 288.39 EINECS: 261-987-3. Use: calcium antagonist, antihypertensive RN MF: C3,H,,N40, MW: 610.71. RN MF: -C3,H3,N40, .2HCI MW: 683.63. Use:...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 122

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Use: anthelmintic RN MF: C,,H,,N,O, MW: 295.30 EINECS: 250-635-4. 620 mglkg (M, p.0.);. Use: antispasmodic RN MF: C2sH35NOs MW: 429.56 EINECS: 222-830-4. 24 mglkg (M, i.v. RN MF: C2sH35N05 . Trade Name(s):. RN MF: C,,H2,N2. 40 mglkg (M, i.v.). 550 mglkg (M, p.0.);. 11.9 mglkg (M, i.v. 90 mglkg (M, p.0.). 92 mglkg (M, p.0.);. Use: antibiotic RN MF: C,,H,,N,O,S...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 123

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Use: tranquilizer, anxiolytic RN MF: Cl6H,JlN2 MW: 270.76 EINECS: 220-783-4. 28.7.1961).. 28.4.1964. 21.7.1964. 11.8.1964. 28.1.1964. 12.4.1961).. ATC: N06A Use: antidepressant RN MF: C1,H,,N02 MW: 257.33 EINECS . RN MF: C,,H,,N02. 11.9.1961).. 17.5.1961. 28.4.1961. 27.2.1961).. D: Clinofem (Pharmacia &. Clinovir (Pharmacia &. Farlutal (Pharmacia &. F: Depo-Prodasone (Pharmacia &. Gestoral (Novartis) Prodasone (Pharmacia &. Provera (Pharmacia &. Premphase (Wyeth-Ayerst) Prempro (Wyeth-Ayerst)...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 124

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Use: diuretic RN MF: Cl,Hl,CIN,OSS, MW: 382.89 EINECS LD. 500 mglkg (M, i.v. 56 mglkg (M, i.v.). 1 g Trade Name(s):. Use: progestogen, antineoplastic RN MF: C25H3204 MW: 396.53 EINECS: 220-859-7. RN MF: C23H3003 MW: 354.49 EINECS: 227-073-3. valid from 19.10.1959. Use: antidepressant RN MF: C2,HZ5N MW: 291.44 EINECS: 225-858-5. 52 mglkg (M, i.v. 3 15 mglkg (M, p.0.);. RN...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 125

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RN MF: C,,H,,N,O,, MW: 1141.36. >2 glkg (M, p.0.) CN: partricin methyl ester. 625 mgkg (R, p.0.) CN: 3-(2-methy1phenoxy)- 1,2-propanediol. RN MF: C3,H,N404 . Use: local anesthetic RN MF: C,5H22N20 MW: 246.35. RN MF: C,,HZ2N2O

Pharmaceutical Substances Syntheses, Patents, Applications - Part 126

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et al.: J. 750 mglkg (M, p.0.);. 794 mglkg (R, p.0.) CN: 2-methyl-2-propyl-l,3-propanediol dicarbamate. RN MF: C,,H,O, MW: 544.69 EINECS LD. 0.25 mg Trade Name(s):. Trade Name(s):. RN MF: C,,H,,NO , HC1 MW: 269.82 EINECS LDso: 282 mglkg (M, p.0.);. et al.: Eur. 23 mglkg (M, i.v. 220 mglkg (M, p.0.);. RN MF: CI7H2,N3O. 25 mglkg (M, i.v. 325 mglkg...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 127

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Use: detoxificant, mucolytic agent RN MF: C2H,Na03S, MW: 164.18 EINECS: 243-285-9. 4440 m g k g (R, p.0.) CN: 2-mercaptoethanesulfonic acid. RN MF: C2H,03S2 MW: 142.20 EINECS: 222-167-0. 400 mg, 600 mg Trade Name(s):. Use: psychosedative, antipsychotic RN MF: C,,H2,N20S2 MW: 386.58. RN MF: C,,H,,N2OS2. Use: anabolic, androgen RN MF: C,0H,202 MW: 304.47 EINECS: 208-302-6. Use: androgen RN MF: C2,H,202...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 128

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Use: antibiotic RN MF: C17Hl,N,0,S MW: 361.42 EINECS: 229-365-6. RN MF: C,,H,,N,NaO,S MW: 383.40. Use: antidepressant RN MF: C,,H,,N, MW: 238.33. RN MF: C,,H,,N. RN MF: CI,Hl,N,. RN MF: C9HI3NO2 . Use: muscle relaxant RN MF: C,,H15N03 MW: 221.26 EINECS: 216-777-6. 230 m g k g (M, s.c.) CN: N,N-dimethylimidodicarbonimidic diamide monohydrochloride. RN MF: C4HllN5 . RN MF: C2,H2,NO ....

Pharmaceutical Substances Syntheses, Patents, Applications - Part 129

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17.5 mglkg (M, i.v. 200 mglkg (R, p.0.) fumarate (2:3). 120 mglkg (M, i.v. 1500 mglkg (M, i.p. 2870 mglkg (M, s.c.). 774 mglkg (M, i.v. 812 mglkg (M, p.0.);. 65 mglkg (M, i.v. 146 mglkg (M, p.0.);. 10.1.1978. 21.3.1978. 12.12.1978. 15.8.1978. 10.5.1978).

Pharmaceutical Substances Syntheses, Patents, Applications - Part 130

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619 mg/kg (M, p.0.);. 3400 mg/kg (R, p.0.). RN MF: C,,H,,N20, MW: 380.40 EINECS methylsulfate. RN MF: C1,H2,N04 , CH3S04 MW: 429.49 EINECS: 241-975-4. 18.10.1960. DE Merck &. 6.10.1960).. US Merck &. FR Merck &. 10.10.1963. GB Merck &. 9.10.1964).. 21.10.1966. Db GB Merck &. D: Caprinol (Bayer Vital)- Sembrina (Boehringer Hydromet (Merck Sharp &. Dopegyt (Thiemann) F: Aldomet (Merck...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 132

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24.1.1979. 24.1.1978).. Use: antiparkinsonian, antispasmodic RN MF: C2,H2,NS MW: 309.48 EINECS: 225-610-6. RN MF: C2,H2,NS . 1460 rnglkg (R, p.0.) hydrochloride monohydrate. RN MF: C,4H22C1N,0. RN MF: CJ4H2,ClN3O2. 12.12.1967. 9.12.1968).. 21.1.1970).. 22.4.1971. 24.4.1970).. 17.12.1971 . 22.4.1971 . 24.8.1973. 12.7.1973).. Use: diuretic, antihypertensive RN MF: C16H,6ClN103S MW: 365.84 EINECS: 241-539-3. 24.12.1966. 25.6.1971. 29.6.1970).. 26.12.1967. 17.7.1970. Use: anti-emetic RN MF: C2,H,N303S2 MW:...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 133

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U S Boehringer Ing.. D: Mexitil (Boehringer Ing.. 1: Mexitil (Boehringer Ing.;. F: Mexitil (Boehringer Ing.. I: Mexitil (Boehringer Ing.. Use: antibiotic RN MF: C,,H,,N50,S2 MW: 539.59 EINECS CN: [2S-[2a,5a,6~(S*)]]-3,3-dimethyl-6-[[[[[3-(methylsulfonyl)-2-0~0-1-. Use: antidepressant RN MF: C,,H2,N2 MW: 264.37 EINECS: 246-088-6. RN MF: C,,HZnN2 . RN MF: C,,H38FN303 .2HC1 MW: 568.56. RN MF: C2,H3,FN3O3 MW: 495.64. synthesis of intermediate 11:. synthesis of...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 134

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25.9.1973. 25.9.1969).. 12.4.1977. 12.2.1980. RN MF: CI2Hl8N2O4 MW: 254.29. RN MF: C,2Hl,N,04. 12.8.1976. Use: ulcer therapeutic RN MF: C4,HS3CoN,O,S MW, 952.98. progesterone and glucocorticoid receptor antagonist, contraceptive RN MF: C,,H35N0, MW: 429.60. 10.6.1982. 28.5.1985. 25.5.1984. 22.1.1985. Use: antidiabetic, a-glucosidase inhibitor RN MF: C,HI,NOs MW: 207.23 EINECS: 276-661-6. 12.7.1979. 24.12.1977. 25.3.1992. Use: antidepressant, 5-HT and norepinephrine reuptake-inhibitor RN MF: C,sH22N20 ....

Pharmaceutical Substances Syntheses, Patents, Applications - Part 135

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Use: antibiotic RN MF: C2,H2,N30, MW: 457.48. RN MF: C23H27N,07. 164 mglkg (R, i.v. 2380 mglkg (R, p.0.). antihypertensive RN MF: C9HI5N5O MW: 209.25 EINECS: 253-874-2. 1321 mglkg (R, p.0.) CN: 6-(1-piperidiny1)-2,4-pyrimidinediamine 3-oxide. D: Lonolox (Pharmacia &. F: Alostil (Sanofi Winthrop) Lonoten (Pharmacia &. 1984) NCoxidil (Galderma) Regaine (Pharmacia &. GB: Loniten (Pharmacia &. 1980) Regaine (Pharmacia &. Loniten (Pharmacia...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 136

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RN MF: C,,H,,CIN202 MW: 268.74 LD. 300 mg Trade Name(s);. RN MF: ClsH,SN02S MW: 273.36 CN: 2-[(diphenylmethyl)sulfinyl]acetamide. RN MF: ClsH15N02S MW form. RN MF: Cl,H15N02S MW form. RN MF: CI5HI5NO2S MW: 273.36. 5.10.1978. SPM-925) Use: antihypertensive (ACE inhibitor) RN MF: C27H,4N,07 MW: 498.58. RN MF: CUH,4N207. 1.10.1981. 3.10.1980).. 19.10.1987. analgesic RN MF: C,,H,,N,O, MW: 232.28 EINECS LD. RN MF: C,,H,,N,NaO,...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 137

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10.10.1991. Use: neuroleptic, antipsychotic RN MF: C22H26FN02 MW: 355.45 EINECS: 213-887-6. RN MF: C,,H26FN0,. 15.5 mglkg (M, i.v. 12.1 mglkg (R, i.v. 152 mglkg (R, p.0.). Use: thrombosis and metastasis prophylactic, antineoplastic RN MF: C19H,lN,0, M W 421 .SO EINECS: 237-145-6. Use: class I antiarrhythmic RN MF: C,,H,,N,O,S MW: 427.53 EINECS: 250-854-5. 11 mglkg (R, i.v.). RN MF: Cz2Hz,N304S ....

Pharmaceutical Substances Syntheses, Patents, Applications - Part 138

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Use: estrogen RN MF: C,,H,O, MW: 326.44. Use: fluoroquinolone antibacterial RN MF: C2,H2,FN3O4. RN MF: CZlH,FN,O4 MW: 401.44. 28.12.1992. RN MF: C,H,,ClN5O MW: 241.68 LD. 12.1 1.1988. RN MF: C,6H,0, MW: 500.63 LD. Use: diuretic RN MF: C,,H,,CI,N,O MW: 272.14 EINECS CN: 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-2,4-dihydro-3H-pyrazol-3-one. immunosuppressive RN MF: C,,H,,NO, MW: 433.50. 12.9.1994. Use: antibiotic, antineoplastic, antiviral RN MF: CI7H2,O6 MW: 320.34 EINECS:...

Pharmaceutical Substances Syntheses, Patents, Applications - Part 139

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Use: anti-emetic, controlled substance RN MF: C24H3603 MW: 372.55. >lo00 mglkg (M, p.0.);. >lo00 mglkg (R, p.0.);. 23.12.1975. 1 mg Trade Name(s):. Use: analgesic, anti-inflammatory (NSAI) RN MF: CI5HlhO2 M W 228.29. 4290 mglkg (M, p.0.);. 3880 mgkg (R, p.0.) CN: 4-(6-methoxy-2-naphthaleny1)-2-butanone. 6.12.1977. 13.12.1983. 7.12.1989. 8.12.1988).. 19.12.1988. 19.6.1985. Use: beta blocking agent, antihypertensive RN MF: C,7H,,N0, MW: 309.41 EINECS: 255-706-3....