- 10.90%) of the pig autosomal genome. - Duroc pigs. - To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.. - The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.. - In humans, Aitman et al. - Zheng et al.. - 2a), while CNVR size ranged from 10.4 kb to 2.7 Mb (Fig. - Qiu et al. - 2c), while CNVR size ranged from 10.4 kb to 2.7 Mb (Fig. - and Canadian Duroc pigs in the 18 autosomes. - We also calculated the frequencies of the CNVRs in the U.S. - Number of overlapped CNVRs in this study Chen et al.. - Wang et al.. - Wiedmann et al. - Xie et al. - Stafuzza et al.. - Keel et al. - 4 The allele frequencies of CNVRs in the U.S. - 5 Manhattan plots of CNVR-based GWAS in the U.S. - All CNVs were merged to generate 953 CNVRs in the two populations, accounting for ~ 10.90% of the pig auto- somal genome (Sus scrofa 11.1). - Dong et al. - and Wang et al. - A similar pattern was observed in the Canadian Duroc pigs. - [50] and Zhuang et al. - Gonzalez et al. - Sharma et al. - Dai et al. - A total of 953 CNVRs were detected in these two popula- tions, accounting for ~ 10.90% of the pig autosomal gen- ome. - We calcu- lated the GC content in the 500 kb genomic region around each SNP derived from the Sscrofa 11.1 version of the pig reference genome (http://ensemble.org/Sus_. - of the target gene in the test sample. - GCG in the test sample. - [(mean C t of the target gene in the reference sample. - GeneCards (http://www.genecards.org/) and Ensembl (www.ensembl.org/biomart/martview) were used to query gene functions.. - org/10.1186/s . - Pig genome ( Sus scrofa 11.1), annotations (v103) and the accession numbers listed in Table S6 and Table S7 can be obtained from ENSEMBL (http://ftp.ensembl.org/pub/release-103/).. - Structural variation in the human genome.. - https://doi.org/10.1038/nrg1767.. - https://doi.. - org/10.1093/nar/gkt958.. - org/10.1038/nrg3871.. - https://doi.org/10.1186/s . - Global variation in copy number in the human genome. - https://doi.org/10.1038/nature05329.. - https://doi.org/10.1146/a nnurev-med . - https://doi.org/10.1038/ng2054.. - https://doi.org/10.1007/s . - https://doi.org/10.1126/. - https://doi.org . - https://doi.org/10.1038/mp.2016.88.. - https://doi.org/10.1038/na ture04489.. - https://doi.org/10.1002/oby.21435.. - https://doi.org/10.1073/pna s . - https://doi.org/10.1111/jpn.12922.. - https://doi.org/10.1371/journa l.pone.0177014.. - https://doi.org/10.3389/fgene . - doi.org/10.1186/s . - https://doi.org/10.1371/journal.pone.. - https://doi.org/10.1111/j x.. - https://doi.org/10.3389/fgene.2018.. - https://doi.org/10.1101/gr.6861907.. - https://doi.org/10.1371/journal.. - https://doi.org/10.1371/journal.pone.0106780.. - https://doi.org/10.1371/journal.pone.0133529.. - doi.org/10.1371/journal.pone.0148565.. - https://doi.org/10.1111/jbg.12435.. - https://doi.org/10.3389/. - https://doi.org/10.1001/jama . - https://doi.org/10.1 093/nar/gkz966.. - https://doi.org/10.1093/nar/gky1120.. - https://doi.org/10.1038/nature08494.. - https://doi.org a.. - https://doi.org/10.1111/age.12402.. - https://doi.org/10.1038/ng2042.. - https://doi.org/10.1371/journal.pone.0006524.. - https://doi.org/10.1111/age.12247.. - https://doi.org/10.33 89/fgene . - https://doi.org/10.1111/age.12888.. - https://doi.org/10.1038/nrg.2016.104.. - https://doi.org/10.1172/JCI45887.. - https://doi.org/10.1016/j.. - https://doi.org/10.1038/ncomms8770.. - https://doi.org/10.1101/gad . - https://doi.org/1 0.1242/dev.155861.. - https://doi.org/10.1194/jlr.R023754.. - https://doi.org/10.1 016/j.meatsci . - https://doi.org/10.1 016/j.tem . - org/10.1210/en.2013-1357.. - https://doi.org/10.1007/s x.. - https://doi.org/10.1016/j.livprodsci . - https://doi.org/10.1038/s . - https://doi.org/1 0.1093/nar/gkn556.. - https://doi.org/10.1093/. - https://doi.org/10.1093/bioinformatics/bts239.. - https://doi.org ST06.. - https://doi.org/10.1016/j.ygeno . - https://doi.org/1 0.1186/s . - https://doi.org/10.1038/ng1696.. - https://doi.org/10.1038/. - https://doi.org/1 0.1016/j.ajhg . - https://doi.org/10.1093/bioinformatics/btl633.
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