Tìm thấy 14+ kết quả cho từ khóa "General anesthetics"
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Background: Although general anesthetics depress spontaneous respiration, the comprehensive effect of general anesthetics on respiratory function remains unclear. We aimed to investigate the effects of general anesthetics on spontaneous respiration in non-intubated mice with different types and doses of general anesthetic..
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General anesthesia induces a reversible unconscious state, allowing medical procedures to be performed without intolerable pain. It is generally considered that general anesthetics interfere with the pathways of neurotransmission that may be involved in the development of the central nervous system (CNS).
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According to their mode of applica- tion, general anesthetics in the restrict- ed sense are divided into inhalational (gaseous, volatile) and injectable agents.. Administra- tion of the volatile anesthetic must then be titrated in such a manner as to coun- terbalance the waning effect of the in- jectable agent.. These drugs are eliminated within minutes after being adminster- ed, irrespective of the duration of anesthesia..
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Background: Some retrospective and in vitro studies suggest that general anesthetics influence breast cancer recurrence and metastasis. We compared the effects of general anesthetics sevoflurane versus propofol on breast cancer cell survival, proliferation and invasion in vitro. homeostasis as a mechanism for general anesthetic-mediated effects on breast cancer cell survival and metastasis..
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Patients with mutations in the ryanodine receptor, which controls intracellular calcium in skeletal muscle and other tissues, may be asymptomatic until exposed to certain general anesthetics, which trigger the syndrome of malignant hyperthermia.
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Sevoflur- ane and propofol are commonly used general anesthetics and have been shown to modulate the inflammatory re- sponses in experimental and clinical studies [14–18].. Thus, our retrospective study aimed to (1) compare the effects of sevoflurane-based inhalational and propofol-based total intravenous anesthesia on the incidence of PP and (2) to identify risk factors of PP following esophagectomy..
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A case of malignant hyperthermia induced by general anesthetics.. Rescue of a patient with malignant hyperthermia in general anesthesia. Successful treatment of malignant hyperthermia during scoliosis correction: a case report. Malignant hyperthermia after general anesthesia in a child with cerebral palsy. Successful treatment of malignant hyperthermia: a case report. Analysis of one case of malignant hyperthermia induced by sevoflurane.
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In this study, patients in the CQLB group required fewer general anesthetics, achieved better over- all analgesic effect after surgery, and had significantly shortened time to first out-of-bed activity and time to. The improved postoperative analgesic effect may promote early ambulation of the patients, and shorter time to flatus means that the patient may recommence eating and swallowing sooner.
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Pain sensation can be influenced or modified as follows:. elimination of the cause of pain. lowering of the sensitivity of noci- ceptors (antipyretic analgesics, local anesthetics). suppression of transmission of noci- ceptive impulses in the spinal me- dulla (opioids). inhibition of pain perception (opi- oids, general anesthetics).
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During pregnancy, general anesthetics may affect brain development of the fetus. The expression of cAMP-response element binding protein (CREB) and phosphorylated cAMP-response element binding protein (p-CREB) was detected in the hippocampus dentate gyrus.. Results: Less offsprings of Iso2 group were able to cross the platform than that of the control group ( P <.
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To test this, we planned a pilot trial to compare the differences in the levels of the superficial endothelial damage biomarker syndecan-1 after tourniquet-induced IR in the presence of general anesthetics. In the same samples, we mea- sured heparan sulfate and thrombomodulin concentra- tions as additional biomarkers of superficial and profound endothelial damage..
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The choice of general anesthetics may not affect Neuroinflammation and impairment of learning and memory after surgery in elderly rats. Reduced AKT phosphorylation contributes to endoplasmic reticulum stress-mediated hippocampal neuronal apoptosis in rat recurrent febrile seizure. Endoplasmic reticulum stress is involved in restraint stress-induced hippocampal apoptosis and cognitive impairments in rats. The role of endoplasmic reticulum stress in neurodegenerative disease.
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Background: Thoracic epidural anesthesia (TEA) exacerbates hypotension due to peripheral vasodilator effects following the use of general anesthetics. This study aimed to compare the hemodynamic changes caused by three different concentrations of epidural ropivacaine and to evaluate the performance of the stroke-volume variation (SVV) and central venous pressure (CVP) during TEA with general anesthesia..
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As adjuncts to general anesthetics, muscle relaxants help to ensure that surgical procedures are not disturbed by muscle contrac- tions of the patient (p. Nondepolarizing muscle relaxants Curare is the term for plant-derived ar- row poisons of South American natives.. Killed game can be eaten without risk because absorption of the poison from the gas- trointestinal tract is virtually nil.
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General anesthetics and vascular smooth muscle:. Yu J, Ogawa K, Tokinaga Y, et al. triphosphate–stimulated, Rho/Rho-kinase–mediated contraction of isolated rat aortic smooth muscle. Yu J, Tokinaga Y, Ogawa K, et al. induced, protein kinase C–mediated but not Ca 2+ -elicited contraction of rat aortic smooth muscle. Qi F, Ogawa K, Tokinaga Y, et al. Yang S, Wu Q, Huang S, et al. Miyamoto Y, Feng GG, Satomi S, et al. Fujii K, Ogawa K, Tokinaga Y, et al.
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Benzocaine (ethoform) is a member of the group of local anesthetics lacking a nitrogen that can be protonated at physiological pH. 208 Local Anesthetics. Local Anesthetics 209. Local anesthetics and pH value 100. Opioid Analgesics—Morphine Type Source of opioids. Besides morphine, opium contains alkaloids devoid of an- algesic activity, e.g., the spasmolytic pa- paverine, that are also classified as opi- um alkaloids.
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All local anesthetics increase 8-OHdG level in esopha- geal carcinoma cells. Local anesthetics. Amide-linked local anesthetics preferentially target leukemia stem cell through inhibition of Wnt/beta- catenin. Effects of local anesthetics on breast cancer cell viability and migration. Antimetastatic potential of amide-linked local anesthetics: inhibition of lung adenocarcinoma cell migration and inflammatory Src signaling independent of sodium channel blockade..
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Further studies are needed to integrate basic scientific findings and clinical data related to the effects of anesthetics on cancer cell progression, anti-cancer immunity, cell-to- cell communication, and clinical outcomes via miRNA modulation. To this end, the molecular effects including miRNAs of anesthetics on cancer cell. Alkire BC, Raykar NP, Shrime MG, Weiser TG, Bickler SW, Rose JA, Nutt CT, Greenberg SLM, Kotagal M, Riesel JN, et al.
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Our findings provide preclinical evidence on how amide-linked local anesthetics could affect melanoma patients.. In line with clinical observations, preclinical studies suggest that amide-linked local anesthetics have anti- tumor effects. Ropivacaine, lidocaine and bupivacaine are amide-linked local anesthetics and act on neuron cells via blocking voltage-gated sodium-channel (VGSC). In addition, local anesthetics preferentially target cancer stem cells [14].
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We aimed to compare general anesthesia (GA) and general anesthesia combined with caudal block (GA + CA) in laparoscopic-assisted Soave pull-through of HD.. Patients were divided into the GA and GA + CA group. The primary outcome was the duration of operation, and secondary outcomes included intraoperative hemodynamic changes, the Face, Legs, Activity, Cry, Consolability (FLACC) scale, dose of anesthetics, and incidence of side effects..