Tìm thấy 10+ kết quả cho từ khóa "Hematopoietic Cell Transplantation"
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Syrjala KL et al: Recovery and long-term function after hematopoietic cell transplantation for leukemia or lymphoma
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Treatment of Specific Diseases Using Hematopoietic Cell Transplantation. Immunodeficiency Disorders. By replacing abnormal stem cells with cells from a normal donor, hematopoietic cell transplantation can cure patients of a variety of immunodeficiency disorders including severe combined immunodeficiency, Wiskott-Aldrich syndrome, and Chédiak-Higashi syndrome.
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Hematopoietic cell transplantation has been used as treatment for a number of storage diseases caused by enzymatic deficiencies, such as Gaucher's disease, Hurler's syndrome, Hunter's syndrome, and infantile metachromatic leukodystrophy. Transplantation is being explored as a treatment for severe acquired autoimmune disorders.
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Hematopoietic Cell Transplantation. Complications Following Hematopoietic Cell Transplant. Early Direct Chemoradiotoxicities. The transplant preparative regimens commonly used cause a spectrum of acute toxicities that vary according to the specific regimen but frequently result in nausea, vomiting, and mild skin erythema (Fig.
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Bone marrow aspirated from the posterior and anterior iliac crests has traditionally been the source of hematopoietic stem cells for transplantation.. Hematopoietic stem cells circulate in the peripheral blood but in very low concentrations. This has made it possible to harvest adequate numbers of stem cells from the peripheral blood for transplantation.
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Several features of the hematopoietic stem cell make transplantation clinically feasible, including its remarkable regenerative capacity, its ability to home to the marrow space following intravenous injection, and the ability of the stem cell to be cryopreserved..
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Peripheral blood stem cells are collected by leukophoresis after the donor has been treated with hematopoietic growth factors or, in the setting of autologous transplantation, sometimes after treatment with a combination of chemotherapy and growth factors. Stem cells for transplantation are generally infused through a large-bore central venous catheter. These symptoms usually resolve with slowing of the infusion.
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Graft failure after allogeneic transplantation can also be due to immunologic rejection of the graft by immunocompetent host cells. common following use of less-immunosuppressive preparative regimens, in recipients of T cell–depleted stem cell products, and in patients receiving grafts from HLA-mismatched donors.. Treatment of graft failure usually involves removing all potentially myelotoxic agents from the patient's regimen and attempting a short trial of a myeloid growth factor.
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The disease is usually treated with glucocorticoids, antithymocyte globulin, or monoclonal antibodies targeted against T cells or T cell subsets.. Between 20 and 50% of patients surviving >6 months after allogeneic transplantation will develop chronic GVHD. The disease is more common in older patients, in recipients of mismatched or unrelated stem cells, and in those with a preceding episode of acute GVHD.
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Allogeneic bone marrow transplantation is the only curative treatment and should be considered in younger patients. reduced-intensity conditioning regimens may permit hematopoietic cell transplantation to be extended to older individuals.. Essential Thrombocytosis.
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Health-related quality of life in patients with newly diagnosed multiple myeloma ineligible for stem cell transplantation:. Background: In the phase III ALCYONE trial, daratumumab plus bortezomib/melphalan/prednisone (D-VMP) significantly improved overall response rate and progression-free status compared with VMP alone in transplant- ineligible patients with newly diagnosed multiple myeloma (NDMM).
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Table 126-2 Common Sources of Infections after Hematopoietic Stem Cell Transplantation. Period after Transplantation. Candida, Aspergillus. Lungs Candida, Aspergillus. Bone marrow HHV-6
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Disease due to CMV can also be associated with the vanishing bile duct syndrome after liver transplantation.. Patients respond to treatment with ganciclovir. prophylaxis with oral forms of ganciclovir or high-dose acyclovir may decrease the frequency of disease. proposed, although the more severe sequelae described in hematopoietic stem cell transplantation are unusual. HHV-6 and HHV-7 appear to exacerbate CMV disease in this setting.
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Reactivation disease or superinfection with another strain from the donor is also common in CMV- positive recipients, and most seropositive patients who undergo hematopoietic stem cell transplantation excrete CMV, with or without clinical findings. Serious CMV disease is much more common among allogeneic than autologous recipients and is often associated with GVHD.
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Bacterial infections are common in the first few days after hematopoietic stem cell transplantation. Beyond the first few days of neutropenia, infections with filamentous bacteria such as Nocardia become more common. Chemotherapy and use of broad-spectrum antibiotics place HSCT patients at risk for diarrhea and colitis caused by Clostridium difficile overgrowth and toxin production.. Fungal Infections.
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While our understanding of the function of αSyn both peripherally and within the central nervous system (CNS) is still developing, several studies have in- dicated that it may play an important role in the hematopoietic system related to exo- and endocytosis, apoptosis, autophagy, maturation, and differentiation of hematopoietic cells [20–23].
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PCR can be used to monitor EBV production after hematopoietic stem cell transplantation. High or increasing viral loads predict an enhanced likelihood of developing EBV-LPD and should prompt rapid reduction of immunosuppression and search for a focus of disease.
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Gahrton G et al: Progress in allogeneic bone marrow and peripheral blood stem cell transplantation for multiple myeloma: A comparison between transplants performed 1983–93 and 1994–8 at European Group for Blood and Marrow Transplantation centers. Greipp PR et al: International staging system for multiple myeloma. Hideshima T, Anderson KC: Novel therapeutic approaches for multiple myeloma. Holland J et al: Plasmacytoma.
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Zerr DM et al: Clinical outcomes of human herpesvirus 6 reactivation after hematopoietic stem cell transplantation
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Intracytoplasmic inclusions were observed in ML-II BM-MSCs both before (BBMT) and after BM transplantation (ABMT) (Figure 1).. Hematopoietic cells colocalized with P0 BBMT ML-II BM-MSCs (Figures 1a and 1b), but not with ABMT BM- MSCs or carrier and donor MSCs despite similar culture conditions (Figure 1).. BM-MSCs from all sources differentiated into adipogenic, osteoblastic, and chondrogenic lineages.