Tìm thấy 14+ kết quả cho từ khóa "Hippocampal neurons"
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Right stellate ganglion block after sleep deprivation alleviated weight loss, pro‑inflammatory cytokines and serum melatonin levels in rat hippocampal tissue Sleep deprivation reduced the body weight of rats com- pared with the control group rats (Fig. Right stellate ganglion block after sleep deprivation alleviated caspase‑3 mediated apoptosis of hippocampal neurons in rats.
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Our previous study have shown that pretreatment of nimodipine could inhibit calcium overload-induced apop- tosis in hippocampal neurons and improve the postopera- tive cognition of aged rats [20]. Our results further showed that pretreatment with nimodipine could reduce incidence of POCD by decreasing CaN mediated hippocampal neuroapoptosis in aged rats.. Therefore, our study choose Morris water maze test to evaluate the cogni- tion of aged rats..
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The neuroprotective effect of endogenous TNF-α is likely mediated by NF-κB activation in neurons, because mice lacking p50 and mice treated with κB decoy DNA exhibit increased vulnerability of hippocampal neurons to excitotoxicity (Yu et al., 1999). The IκB kinase complex (IKK) is also activated in a mouse model of stroke and appears to play a key function in ischemic brain damage (Herrmann et al., 2005).
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Injection of miR-214 inhibitor attenuated the effect of DEX in MCAO rats by increasing the area of cerebral infarction in rats and apoptosis rate of hippocampal neurons. ROCK1 was targeted and negatively regulated by miR-214. Conclusion: Therapeutic effects of DEX on CIRI was elicited by overexpressing miR-214 and impairing ROCK1 expression and NF- κ B activation.
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Panel B shows the antibody reactivity with cultures of rat hippocampal neurons. the intense green immunolabeling is due to the antibodies against the NR1/NR2 subunits of NMDA receptors.. Only four of the antibodies listed in Table 97-2 have been shown to play a direct pathogenic role in PNDs. all produce distinctive disorders of the peripheral nervous system.
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Dexmedetomidine on autophagy of hippocampal neurons in aged rats under sevoflurane anesthesia. Dexmedetomidine exerts neuroprotective effect via the activation of the PI3K/Akt/mTOR signaling pathway in rats with traumatic brain injury. Anesthetic immunomodulation of the Neuroinflammation in postoperative cognitive dysfunction. Neuroinflammatory challenges compromise neuronal function in the aging brain: postoperative cognitive delirium and Alzheimer's disease.
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Effects of dexmedetomidine on hippocampal focal adhesion kinase tyrosine phosphorylation in physiologic and ischemic conditions. Protective effects of paeonol on cultured rat hippocampal neurons against oxygen-glucose deprivation- induced injury. Effects of scutellarin on PKCgamma in PC12 cell injury induced by oxygen and glucose deprivation. Secondary energy failure after cerebral hypoxia-ischemia in the immature rat.
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Pretreatment with resveratrol did not affect the number of hippocampal neurons in aged mice after surgery.. Conclusion: Overall, resveratrol pretreatment attenuated short-term learning and memory impairment and the ERS pathway UPR in aged mice after surgery under local anesthesia.. Keywords: Resveratrol, Endoplasmic reticulum stress, Cognitive function, Surgery, Aged mice.
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In glutamate-stimulated hippocampal neurons, the return of p65 from neuritic to nuclear distribution was observed (Wellmann et al., 2001. Meffert et al., 2003).. Unlike most other cells, NF-κB is constitutively activated, which appears to be the result of synaptic activity (Kaltschmidt et al., 1994).
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Evidence regarding the role of tau was obtained from earlier studies on cultured cerebellar neurons using antisense oligonucleotides (Kosik, 1990a,b). Primary cultures of hippocampal neurons lacking tau exhibit decreased rates of neurite extension and inhibited neuronal polarization (i.e., the development of axons and dendrites. Dawson et al., 2007), during axono- genesis, tau function appears to be locally regulated by phosphorylation.
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Additionally, in females, extracellular matrix deposition on hippocampal neurons was higher in individuals with small relative to large social network size.. The last twenty years have seen a lot of progress in the understanding of the neural circuits, neuropeptides and neuromodulators involved in vertebrate social behavior [11–15].
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YM- 201636 mediated PIKfyve inhibition significantly reduced the survival of primary mouse hippocampal neurons and promoted vacuolation of endolysosomal membranes followed by apoptosis-independent cell death (Martin et al., 2013). The aim of the present study was to investigate the effects of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) inhibitor, YM201636, on nonsmall cell lung cancer (NSCLC) cells growth, tumorigenicity, and claudin (CLDN) expressions.
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Long-term effects of prenatal stress on the characteristics of hippocampal neurons in rats with different excitability of the nervous systems. Isolation of the constitutive heterochromatin from mouse liver nuclei. Sequence organization and cytological localization of the minor satellite of mouse. Tandemly repeated DNA families in the mouse genome. Isolation of the chromocenter fraction from mouse liver nuclei. caltractins in the centriole and in genome maintenance.
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Yu Z, Zhou D, Bruce-Keller AJ, Kindy MS, Mattson MP (1999) Lack of the p50 subunit of nuclear factor-kappaB increases the vulnerability of hippocampal neurons to excitotoxic injury.. Yu Z, Zhou D, Cheng G, Mattson MP (2000) Neuroprotective role for the p50 subunit of NF- kappaB in an experimental model of Huntington’s disease. plex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation.
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Downregulation of MicroRNA-33-5p protected bupivacaine-induced apoptosis in murine dorsal root ganglion neurons through GDNF. Tetramethylpyrazine attenuated bupivacaine-induced neurotoxicity in SH- SY5Y cells through regulating apoptosis, autophagy and oxidative damage.. The neurotoxicity of local anesthetics on growing neurons: a comparative study of lidocaine, bupivacaine, mepivacaine, and ropivacaine. Antioxidants prevent ethanol-associated apoptosis in fetal rhombencephalic neurons.
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Keywords: ginsenoside Rb1, ginsenoside Rg1, organotypic hippocampal slice cultures, oxygen and glucose deprivation, Panax notoginseng..
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Formation of the receptive fields of leech mechanosensory neurons during embryonic development
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A recent study demonstrated that the ARHGEF6 protein is present in CA3 and CA1 neurons of the hippocampus and that expression of epitope-tagged ARHGEF6 in hippocampal slice cultures shows a punctate staining in dendritic spines that colocalizes with PSD-95 and other synaptic proteins (Node-Langlois et al., 2006).
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Consistently, hippocampal LTP on day 1 was significantly suppressed in the desflurane group compared with the control group ( P = 0.006).
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Differentially regulated genes in VLPO-gal neurons between sleep and sleep deprivation.