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Lymphocyte infiltration

Tìm thấy 11+ kết quả cho từ khóa "Lymphocyte infiltration"

Infiltration of CD1a-positive dendritic cells in advanced laryngeal cancer correlates with unfavorable outcomes postlaryngectomy

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DCs and reported that the infiltration of CD1a + DCs was not associated with survival, although it was significantly associated with lymphocyte infiltration [24]. report an association between poor surgical outcomes and tumor infiltrating CD1a + DCs in laryngeal cancer..

Prognostic role of DFNA5 in head and neck squamous cell carcinoma revealed by systematic expression analysis

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High DFNA5 expression results in decreased lymphocyte infiltration in HNSCC. To further explore the function of DFNA5 in HNSCC and its prognostic potential, we focused on the infiltra- tion of immune cells in the HNSCC tumor microenvir- onment. Specifically, we used TIMER to investigate whether the expression of DFNA5 is related to the level of immune cell infiltration.

Drug-induced hypersensitivity syndrome caused by minodronic acid hydrate

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Transbronchial lung cryobiopsy specimens showed that lymphocyte infiltration was observed in the alveolar walls and fibrinous exudates and floating macrophages in the alveolar lumina.. Minodronic acid hydrate was identified as the culprit drug based on the positive results of the patch test and drug- induced lymphocyte stimulation test.. Conclusions: We described the first case of DIHS caused by minodronic acid hydrate.

Comparison of the molecular and cellular phenotypes of common mouse syngeneic models with human tumors

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These syngeneic models have relatively low T-lymphocyte infiltration. The baseline immune infiltration of a panel of syngeneic models (Table 1) was evaluated by transcription profiling and chromogenic IHC.

Nefopam downregulates autophagy and c-Jun N-terminal kinase activity in the regulation of neuropathic pain development following spinal nerve ligation

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Hematoxylin and eosin staining on Day 14 post-SNL revealed that SNL caused lymphocyte infiltration and oligodendrocyte localization in the substantia gelatinosa of the dorsal gray horn, which were reduced by nefopam injection.. Conclusion: Collectively, the mode of action of nefopam on neuropathic pain appears to be associated with downregulation of phospho-JNK and autophagy, as well as modulation of the immune response..

Influence of Epstein–Barr virus and human papillomavirus infection on macrophage migration inhibitory factor and macrophage polarization in nasopharyngeal carcinoma

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Barr virus (EBV) infection and substantial lymphocyte infiltration [3], which consists of the immune micro- environment, indicating the importance of EBV and the tumor microenvironment in NPC pathogenesis. M2 macrophages are charac- terized as anti-inflammatory macrophages and are in- volved in the promotion of angiogenesis and tumor progression [9].

Accelerated hematopoietic mitotic aging measured by DNA methylation, blood cell lineage, and Parkinson’s disease

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Furthermore, studies have also shown that neurodegenerative disease patients experience lymphocyte infiltration from the periphery in the central nervous system (CNS challenging the conventional belief that the CNS is “immune privi- leged”, i.e. It is unclear whether αSyn may be involved in the hematopoietic alterations in PD apart from inducing in- flammation.

A high CD8 to FOXP3 ratio in the tumor stroma and expression of PTEN in tumor cells are associated with improved survival in non-metastatic triple-negative breast carcinoma

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Together, these data suggest that the T lympho- cytes in the tumor microenvironment may exhibit antitumor activity and promote growth control, as opposed to events favoring immunosuppression (regulatory lymphocyte infiltration). This data is rep- licated in the TNBC cohort of METABRIC for those patients whose tumors have a high CD8A/FOXP3 ratio..

The role of FoxP3+ regulatory T cells and IDO+ immune and tumor cells in malignant melanoma – an immunohistochemical study

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IDO+ stromal immune cells mainly accumulated in the areas with clear lymphocyte infiltration and thus resided mostly in the perilesional stroma, similar to FoxP3+ Tregs. Part of the IDO+ stromal immune cells were CD68+ and CD11c + antigen presenting cells (Fig. The morphology of IDO+ stromal immune cells also resembled the morphology of den- dritic cells with numerous cytoplasmic processes.

18F-FDG-PET-MRI for the assessment of acute intestinal graft-versus-host-disease (GvHD)

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Previous PET-MRI studies in inflammatory bowel disease mainly focused on the correlation of quantitative MRI and PET parameters with histological scores on a per segment basis . 18 F-FDG uptake and lymphocyte infiltration in a preclin- ical model of intestinal GvHD. 3 Coronal MR- and fused PET-MRI images of a patient with acute intestinal GvHD.

Gut microbiome and its role in colorectal cancer

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Preclini- cal studies have demonstrated that Bifidobacterium pro- mote dendritic cell and CD8+ T lymphocyte infiltration in the tumour microenvironment, thereby promoting the same effects as immunotherapy in terms of elimination of tumours [47]. among the gut microbiota, antibiotics and immuno- therapy. Potential applications of the gut microbiome in clinical practice. The gut microbiome has many potential roles in dealing with CRC.

Evaluation of a combination “lymphocyte apoptosis model” to predict survival of sepsis patients in an intensive care unit

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The associations between lymphocyte apoptosis and clinical severity and between lymphocyte apoptosis and other components of the lymphocyte apop- tosis score were evaluated using Pearson and Spearman rank correlations.

Identification of an at-risk subpopulation with high immune infiltration based on the peroxisome pathway and TIM3 in colorectal cancer

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Prediction of the immunotherapy response for each subgroup. org/) to compare the similarity of the gene expression profiles of our sub- groups to those of melanoma patients treated with check- point blockades against programmed cell death protein-1 (PD1) or cytotoxic T lymphocyte antigen-4 (CTLA4) [35]..

Neutrophil-to-lymphocyte ratio as a prognostic factor for patients with metastatic or recurrent breast cancer treated using capecitabine: A retrospective study

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NLR: neutrophil‑to‑lymphocyte ratio. PLR: platelet‑to‑lymphocyte ratio.

Wound infiltration with ropivacaine as an adjuvant to patient controlled analgesia for transforaminal lumbar interbody fusion: A retrospective study

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Since Mullen and Cook first demonstrated the use of wound infiltration with local anesthetics in spine surgery in a few literatures reported the appli- cation of wound infiltration with local anesthetics in sev- eral surgical procedures. found that local infiltration analgesia had a reduction of VAS and morphine consumption in postoperative pain control.

Cerebrospinal fluid cytokine levels are associated with macrophage infiltration into tumor tissues of glioma patients

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Accordingly, differences between the tumor core and in- filtration zone were analyzed if at least one infiltration zone was present in the sample.

Association of neutrophil-to-lymphocyte ratio with severe radiation-induced mucositis in pharyngeal or laryngeal cancer patients: A retrospective study

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Elevated C-reactive protein and neutrophil-to-lymphocyte ratio (NLR) were associated with more advanced disease and poorer prog- nosis in oral cavity squamous cell carcinoma patients [9]. Moreover, head and neck squamous cell carcinoma cancer patients with NLR >.

Integration of circulating tumor cell and neutrophil-lymphocyte ratio to identify high-risk metastatic castration-resistant prostate cancer patients

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Prognostic significance of neutrophil-to-lymphocyte ratio in prostate cancer: evidence from 16,266 patients. https://doi.org/10.1038/srep22089.. https://doi.org/10.1111/bju.12531.. Neutrophil- lymphocyte ratio is a predictor of prognosis in patients with castration- resistant prostate cancer: a meta-analysis. https://doi.org/10.2147/CMAR.S159105.. https://doi.org/10.1038/s y.. doi.org/10.1007/s .

Ropivacaine infiltration analgesia of the drainage exit site enhanced analgesic effects after breast Cancer surgery: A randomized controlled trial

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Ropivacaine infiltration during breast cancer surgery: postoperative acute and chronic pain effect. Wound infiltration with ropivacaine and fentanyl: effects on postoperative pain and PONV after breast surgery. Preemptive ropivacaine local anesthetic infiltration versus postoperative ropivacaine wound infiltration in mastectomy: postoperative pain and drain outputs. A double blind randomized trial of wound infiltration with ropivacaine after breast cancer surgery with axillary nodes dissection.

Pharmacokinetics and safety of liposomal bupivacaine after local infiltration in healthy Chinese adults: A phase 1 study

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Pharmacokinetic profile and tolerability of liposomal bupivacaine following a repeated dose via local subcutaneous infiltration in healthy volunteers