Có 20+ tài liệu thuộc chủ đề "BMC Cancer"
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Four visits will be scheduled at diagnosis, after treatments, and 12 and 18 months after diagnosis. The same procedure will be followed for each visit. Each session will be composed of anthropometric data collection, a semi-structured interview, cognitive tests, postural control tests, neuromuscular fatigability tests and a cardiorespiratory fitness test. Clinical and biological data will be collected during medical follow-ups....
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Background: Correct preoperative estimation of the malignant extent is crucial for optimal planning of breast cancer surgery. CEM may be more cost- effective than MRI, and may provide better identification of the tumor extent, however, no randomized trials have been performed to date to investigate the added value of CEM.. The purpose of the present study is to evaluate the...
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Methods: In this international multicentre prospective incremental diagnostic accuracy study, 298 patients with primary or recurrent CRLM scheduled for curative liver resection or thermal ablation based on CT staging will be enrolled from 17 centres across the Netherlands, Belgium, Norway, and Italy. Furthermore, a prediction model will be developed using multivariable logistic regression modelling to evaluate the predictive value of...
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A randomized phase III study of short- course radiotherapy combined with Temozolomide in elderly patients with newly diagnosed glioblastoma. Makoto Ohno 8 , Yoshinori Ito 9 , Ryo Nishikawa 10 , Haruhiko Fukuda 2 , Yasumasa Nishimura 11 , Yoshitaka Narita 8 and Brain Tumor Study Group and Radiation Therapy Study Group of the Japan Clinical Oncology Group. Background: The...
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Methods: We retrospectively analyzed 1515 MPA patients in SEER database. Results: No significant differences were noted in OS and CSS time. The MPA patients who were treated with surgery and chemotherapy exhibited longer OS and CSS time periods than those without treatment. MPA patients treated with radiotherapy exhibited similar OS and CSS time with those without radiotherapy. Conclusions: MPA was...
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The 6-h samples showed activation of the cell cycle inhibitor CDKN1A which might be involved in the secondary response in 12-h samples.. This secondary response predominantly consisted of cell cycle-related changes, with further activation of CDKN1A and inhibition of the transcription factor E2F1 , including downstream target genes, resulting in G1-phase arrest.. Conclusions: FX-9 induced G1-phase arrest of PC-3 cells...
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Socioeconomic position and prediagnostic health care contacts in children with cancer in Denmark: a nationwide register study. Hypothesized mechanisms include prediagnostic utilization of and navigation through the health care system, which may differ by socioeconomic resources of the families. In this nationwide register-based study we investigated the association between measures of family socioeconomic position in relation to prediagnostic health care...
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Results: P-spline regression revealed a dependence of patient outcomes on GTVp, with 30 cm 3 being an optimal cut-off for differences in overall and progression-free survival (OS, PFS). GTVp ≥ 30 cm 3 was a negative independent prognostic factor for OS and PFS. 30 cm 3 , no significant survival differences were observed among the 3 treatments. For GTVp ≥...
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Despite the genetic heterogeneity of the leukemias studied, transcriptional analysis found concerted changes in gene expression in resistant blasts. The refractory gene signature was highly enriched with targets of the transcription factor FOXM1. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless...
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Full list of author information is available at the end of the article. Interestingly, it is observed that following NAC, approxi- mately 20 to 40% of patients have no residual urothelial cancer cells on histological examination of the RC speci- men and on ePLND [9 – 11]. The 10 – 15% of patients who develop distant metastases early after NAC...
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β -catenin signal pathway in prostate cancer cells. The efficacy of the combination of BZM and mitoxantrone (MTX) in treating prostate cancer remains unknown.. Results: BZM significantly enhanced MTX-induced antiproliferation in vivo and in vitro. BZM significantly attenuated MTX-induced apoptosis. Conclusions: This study demonstrates that BZM enhances MTX-induced anti-tumor effects by inhibiting the Wnt/ β - Catenin signaling pathway in...
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mesothelioma in contrast enhanced MDCT – arterial phase or late phase?. Background: To determine if late phase is superior to arterial phase intraindividually regarding conspicuity of MPM in contrast enhanced chest MDCT.. For all patients, chest CT in standard arterial phase (scan delay ca. Differences of absolute HUs in tumor lesions between phases and differences of contrast (HU in lesion...
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Exploring the clinical value of preoperative serum gamma-glutamyl transferase levels in the management of patients with. hepatocellular carcinoma receiving postoperative adjuvant transarterial chemoembolization. This study aimed to investigate whether γ -GT levels could be taken as a biomarker to guide the management of PA-TACE in resectable HCC.. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.. 0.05), and patients with...
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TFEB, SIRT1, CARM1, Beclin-1 expression and PITX2 methylation in breast cancer chemoresistance: a retrospective study. Background: Breast cancer chemoresistance is attributed to a wide variety of mechanisms, including autophagy.. Objective: This study aims to evaluate the prognostic impact of TFEB and its pathway in breast cancer chemoresistance.. A group of breast cancer patients treated with chemotherapy, who relapsed within 12...
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Types of second primary cancer influence overall survival in cutaneous melanoma. Background: Favorable survival in malignant cutaneous melanoma (melanoma) has increased the likelihood of second primary cancer (SPC). We assess the influence of patient characteristics at diagnosis of first melanoma and the type of SPC (second melanoma and other SPC) on overall survival.. Methods: We used the Swedish Cancer Registry...
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Associations between hepatitis B virus infection and risk of colorectal Cancer: a population-based prospective study. However, research concerning the effect of HBV infection on the risk of colorectal cancer (CRC) is rare and inconsistent. This study aims to determine the relationship between HBV infection and new-onset CRC.. Methods: We prospectively examined the relationship between HBV infection and new-onset CRC among...
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with multi-vendor chest radiographs: a retrospective clinical validation study. Background: We investigated the performance improvement of physicians with varying levels of chest radiology experience when using a commercially available artificial intelligence (AI)-based computer-assisted detection (CAD) software to detect lung cancer nodules on chest radiographs from multiple vendors.. Methods: Chest radiographs and their corresponding chest CT were retrospectively collected from one...
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trophoblastic neoplasia: a meta-analysis of randomized and high-quality non-. The primary objective of this meta-analysis is to compare Act-D with MTX in the treatment of LRGTN.. A fixed-effects meta-analysis was conducted to quantify the efficacy and safety of Act-D and MTX on odds ratios (ORs) and 95% confidence intervals (95%CIs), respectively.. OR 2.15, 95%CI 1.70 to 2.73). In the stratified...
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model of bone cancer pain. We investigated the effects of dezocine, a mu- and kappa-opioid receptor agonist/antagonist, on morphine tolerance and explored the involvement of opioid receptor expression in a rat model of bone cancer pain.. Real-time PCR and western blot analysis were used to examine opioid receptor expression in the periaqueductal gray (PAG) and spinal cord.. Low-dose dezocine coadministration...
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Phase II study of multidisciplinary therapy combined with pembrolizumab for patients with synchronous oligometastatic non-. Several clinical trials have shown that local ablative therapy (LAT) at all sites of the disease might be beneficial for patients with oligometastatic NSCLC. In recent years, the combination of programmed cell death 1 (PD-1) inhibitors or programmed cell death ligand 1 with cytotoxic chemotherapy...