Có 20+ tài liệu thuộc chủ đề "Overall survival"
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Construction of an 11-microRNA-based signature and a prognostic nomogram to predict the overall survival of head and neck squamous cell carcinoma patients. Background: Head and neck squamous cell carcinoma (HNSCC) is a fatal malignancy owing to the lack of effective tools to predict overall survival (OS). Accordingly, in the present study, miRNA. Forty-three HNSCC samples were assigned to an internal...
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A randomized phase III study of short- course radiotherapy combined with Temozolomide in elderly patients with newly diagnosed glioblastoma. Makoto Ohno 8 , Yoshinori Ito 9 , Ryo Nishikawa 10 , Haruhiko Fukuda 2 , Yasumasa Nishimura 11 , Yoshitaka Narita 8 and Brain Tumor Study Group and Radiation Therapy Study Group of the Japan Clinical Oncology Group. Background: The...
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Types of second primary cancer influence overall survival in cutaneous melanoma. Background: Favorable survival in malignant cutaneous melanoma (melanoma) has increased the likelihood of second primary cancer (SPC). We assess the influence of patient characteristics at diagnosis of first melanoma and the type of SPC (second melanoma and other SPC) on overall survival.. Methods: We used the Swedish Cancer Registry...
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chemotherapy in selected populations of patients with treatment-naive unresectable hepatocellular carcinoma exhibiting PD-L1 staining: a multicenter retrospective study. Background: Not all patients with unresectable hepatocellular carcinoma (uHCC) benefit from treatment with immune checkpoint inhibitors and molecular-targeted agents. Methods: Consecutive patients with treatment-naive uHCC exhibiting PD-L1 staining who were treated with pembrolizumab plus lenvatinib plus HAIC (PLH) or pembrolizumab plus lenvatinib...
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Lymph node ratio as a predictor for minor salivary gland cancer in head and neck. Background: We investigate whether pathological continuous variables of lymph nodes were related with survival results of carcinomas of minor salivary gland carcinoma in head and neck.. The pathological continuous variables were evaluated by the number of positive lymph nodes, lymph node ratio, and log odds...
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The primary objective of the MULTISARC trial is to assess whether NGS can be conducted for a large proportion of metastatic STS participants within a reasonable time, and, secondarily to determine whether a NGS-guided therapeutic strategy improves participant ’ s outcome.. NGS will be considered feasible if (i) NGS results are available and interpretable, and (ii) a report of exome...
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Ado-trastuzumab for the treatment of metastatic HER2-positive breast cancer in patients previously treated with. Background: Docetaxel in combination with two HER2-directed therapies, trastuzumab and pertuzumab, is the current standard frontline therapy for patients with metastatic HER2-positive breast cancer. However, the benefit of T-DM1 in patients previously treated with pertuzumab therapy for metastatic breast cancer remains unclear.. Methods: We identified thirty-three...
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Survival improvement and prognosis for hepatocellular carcinoma: analysis of the SEER database. Background: Hepatocellular carcinoma (HCC) incidences have been increasing in the United States. OS and DSS of patients with HCC improved over time ( P <. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available...
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Phase II trial of nab-paclitaxel in metastatic breast cancer patients with visceral. Background: Visceral metastases account for 48 – 67% of metastatic breast cancer (MBC) patients and presage a worse overall survival. Previous study suggested potential effect of nab-paclitaxel on patients with visceral. This phase II trial was conducted to explore the efficacy and safety of nab-paclitaxel in such a...
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Tumor response as defined by iRECIST in gastrointestinal malignancies treated with PD-1 and PD-L1 inhibitors and correlation with survival. This study evaluated tumor burden dynamics to identify imaging biomarkers for treatment response and overall survival (OS) in advanced gastrointestinal malignancies treated with PD-1/PD-L1 inhibitors.. gastrointestinal malignancies treated with PD-1/PD-L1 inhibitors between January 2017 and March 2021. Tumor diameter changes as...
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Comprehensive analysis of lymph nodes metastasis associated genes in cervical cancer and its significance in treatment and prognosis. The risk score model was constructed and validated in cervical carcinoma patients. Conclusion: Our study revealed that lymph node metastasis played an important role in the prognosis of cervical carcinoma patients. Furthermore, we established a risk score model based on lymph node...
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ROR1 protein expression was not associated with stage, grade or OS in the APGI cohort.. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.. International Cancer Genome Consortium (ICGC, https://icgc.org/),the Cancer Genome Atlas...
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Methods: Published clinical trials in the PubMed, Medline, Embase databases on PD-1 inhibitors for the treatment of ESCC were searched, along with an additional search on abstracts from the American Society of Clinical Oncology (ASCO) and European Society for Medical Oncology (ESMO) from inception to September 2021. P = 0.01) of advanced ESCC patients, especially significantly prolonged the OS in...
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The association of aspirin use with overall. survival of patients with inoperable non-small cell lung cancer: a retrospective study. Background: Studies have indicated that individuals taking aspirin have a reduced risk of cancers and have also established chemo‑preventive benefit of aspirin in colorectal cancer. However, research on the association between aspirin use and the survival in patients with lung cancer...
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Corticosteroid switch from prednisone to dexamethasone in metastatic castration- resistant prostate cancer patients with biochemical progression on abiraterone acetate plus prednisone. Background: To assess the efficacies and potential predictors of a corticosteroid switch in metastatic castration- resistant prostate cancer (mCRPC) patients with biochemical progression on abiraterone acetate plus prednisone (A + P).. Lower PSA at corticosteroid switch. A risk stratification...
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Multiple myeloma in Armenia during the period facts and discussion. Background: It is known that one of the reasons for the increased incidence of hematological malignancies is caused by the growth of multiple myeloma (MM). Despite significant advances in the MM treatment the mortality rates are still high. Interestingly, there were no sex differences in the overall MM incidence during...
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Preferences of first-degree relatives of gastric cancer patients for gastric cancer screening: a discrete choice experiment. Background: It is very necessary to implement gastric cancer screening in China to reduce the mortality of gastric cancer, but there are no national screening guidelines and programs. In addition, the first-degree relatives of gastric cancer patients are at high risk for gastric cancer....
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Prognostic significance of the. postoperative prognostic nutritional index in patients with glioblastoma: a. We evaluated the effects of postoperative PNI and perioperative changes in the PNI on overall survival (OS) in glioblastoma (GBM) patients.. Patients were classified into high ( n = 206) or low ( n = 129) postoperative PNI groups according to the postoperative PNI cutoff value and...
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Association between preoperative serum albumin and prognosis in patients with adrenocortical carcinoma after primary resection: a retrospective study. Background: Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with a poor prognosis. In this study, we aim to assess the correlation between preoperative serum albumin and prognosis in patients with ACC after primary resection.. In multivariate analysis, serum albumin as...
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This phase 2 trial aims to validate the efficacy of the proposed intervention.. Full list of author information is available at the end of the article. Methods: The trial is designed as a comparative, 1:1 randomized, minimax two-stage phase 2 with an expected 70 patients to a maximum sample size of 84 patients. After 12-months follow-up of the first 52...