Có 20+ tài liệu thuộc chủ đề "Colorectal cancer"
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https://doi.org/10.. https://doi.. org/10.1038/nrg2484.. https://doi.org/10.3390/. https://doi.org/10.1093/. https://doi.org/10.1038/nprot.2012.016.. https://doi.org bi1107s32.. https://doi.org/10.1093/bioinformatics/btu638.. https://doi.org/10.1093/nar/gkt214.. https://doi.org . https://doi.org/10.1186/gb r106.. https://doi.org/10.1186/s . org/10.1186/s x.. https://doi.org/10.1186/. https://doi.org/10.1091/mbc.10.6.1859.. https://doi.org/10.5114/wo . https://doi.org/10.1016/j.. https://doi.org/10.1093/bioinformatics/btp352.. https://doi.org/10.1371/. Bioconductor.org. https://doi.org/10.1109/TFUZZ . https://doi.org/10.1073/pnas.. https://doi.org/10.1093/nar/. https://doi.org/10.18632/. https://doi.org/. https://doi.org CIR- 13-0124.. https://doi.org/10.1128/MCB.00358-10.. https://doi.org CAN-09-4444.. https://doi.org/10.1016/j.ejcb . https://doi.org/10.1371/journal.pone.0202113.. https://doi.org/10.1371/journal.pone.0008884.. https://doi.org/10.1371/journal.pone.0036301.. https://doi.org/10.1016/j.ejca . doi.org/10.1111/bjh.13188.. https://doi.org/10.1177/. https://doi.org/10.1371/journal.pone.. https://doi.org/10.1002/ijc.29803.. https://doi.org/10.1016/j.canlet . doi.org/10.3892/or.2015.3993.. https://doi.org/10.1007/s . https://doi.org/10.1186/gm437.. https://doi.org/10.1016/j.gene . https://doi.org/10.1074/jbc.M116.738567.. https://doi.org/10.3892/ijo.. https://doi.org/10.1002/gcc.22447.....
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The stability and robustness of the gene survival markers was assessed by cross-validation, and the best-ranked genes were also validated with two external independent cohorts: one of microarrays with 482 samples. Up-regulation of the top genes was also proved in a comparison with normal colorectal tissue samples. This risk predictor yielded an optimal separation of the individual patients of the...
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HK3 overexpression associated with epithelial-mesenchymal transition in colorectal cancer. Background: Colorectal cancer (CRC) is a common cancer worldwide. Correlation analysis between the change in the expression of genes involved in glycolysis and EMT was performed. The mRNA level of these genes was measured in 78 paired colorectal cancer samples by quantitative polymerase chain reaction (qPCR). The results of correlation study...
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Methods: In this international multicentre prospective incremental diagnostic accuracy study, 298 patients with primary or recurrent CRLM scheduled for curative liver resection or thermal ablation based on CT staging will be enrolled from 17 centres across the Netherlands, Belgium, Norway, and Italy. Furthermore, a prediction model will be developed using multivariable logistic regression modelling to evaluate the predictive value of...
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Associations between hepatitis B virus infection and risk of colorectal Cancer: a population-based prospective study. However, research concerning the effect of HBV infection on the risk of colorectal cancer (CRC) is rare and inconsistent. This study aims to determine the relationship between HBV infection and new-onset CRC.. Methods: We prospectively examined the relationship between HBV infection and new-onset CRC among...
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Pooled analysis of combination antiemetic therapy for chemotherapy-induced nausea and vomiting in patients with colorectal cancer treated with oxaliplatin-based chemotherapy of moderate emetic risk. Female and 2 antiemetics were risk factors for both delayed nausea (female — odds ratio [OR]: 1.918. Conclusions: Identifying individual risk factors can facilitate personalized treatments for delayed CINV. We recommend a 3-antiemetic combination prophylaxis for...
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interventions in the colorectal cancer care pathway: a process evaluation of the. The aim of the process evaluation was to optimise intervention implementation for the main trial.. Patients ’ exercise history and motivation prior to surgery influenced HCP perceptions and delivery of the motivational components. Observations indicated a high level of fidelity to delivery of the exercise interventions. All but...
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Patients in the low-risk group were more likely to have higher tumor mutational burden, stem cell characteristics, and higher PD-L1 expression levels. Although most studies of alterations in cancer me- tabolism have focused on glucose metabolism (i.e., the Warburg effect), the role of abnormal lipid metabolism in cancer cells has been gradually recognized over the past few years [14, 15]....
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Thus, the present results suggest that CIB1 may play a crucial role for hematogenous spread to the liver but not for peritoneal carcinomatosis. 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the...
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The association of aspirin use with overall. survival of patients with inoperable non-small cell lung cancer: a retrospective study. Background: Studies have indicated that individuals taking aspirin have a reduced risk of cancers and have also established chemo‑preventive benefit of aspirin in colorectal cancer. However, research on the association between aspirin use and the survival in patients with lung cancer...
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LncRNA MCF2L-AS1 aggravates the malignant development of colorectal. cancer via targeting miR-105-5p/RAB22A axis. Aim: We aimed at exploring the function and regulatory mechanism of MCF2L-AS1 in CRC.. Methods: MCF2L-AS1 expression in CRC cells was tested via RT-qPCR assay. The effects of MCF2L-AS1 on the biological properties of CRC cells were testified through functional experiments. The molecular mechanism of MCF2L-AS1 was...
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Exosomal circEIF3K from cancer-associated fibroblast promotes colorectal cancer (CRC) progression via miR-214/PD-L1 axis. Conditioned medium (CM) and exosome from circEIF3K knockdown CAF significantly attenuated proliferation, invasion and tube formation of HCT116 or SW620 cells, which could be reverted by miR-214 under hypoxia treatment. Finally, PD-L1 was confirmed as important target for miR-214 in CRC.. Conclusion: In conclusion, our study reveals...
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screening in a medically underserved population with the addition of blood- based testing. Background: Adherence to colorectal cancer screening in the United States is suboptimal, particularly in medically underserved populations due to significant barriers to care. In this article, we assess patient preference and the impact of offering a blood-based test on screening rates in a cost-free health fair setting...
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Randomized phase II study of SOX+B-mab versus SOX+C-mab in patients with. previously untreated recurrent advanced colorectal cancer with wild-type KRAS (MCSGO-1107 study). Background: Although chemotherapy for metastatic colorectal cancer (mCRC) has improved, the standard chemotherapy regimens for patients with RAS wild-type mCRC remain debated. bevacizumab (B-mab) with SOX + cetuximab (C-mab) in patients with previously untreated recurrent advanced CRC with...
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Colorectal cancer survival among Ministry of National Guard-Health Affairs (MNG-HA) population retrospective study. Background: Colorectal cancer (CRC) is the most diagnosed cancer among males and third among females in Saudi Arabia, with up to two-third diagnosed at advanced stage. Nearly, one-fourth of the patients presented with rectal tumor, 42.89% with left colon and 33.41% of the cases were diagnosed at...
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Circulating MiR-1290 as a potential diagnostic and disease monitoring biomarker of human gastrointestinal tumors. As shown in our previous study, miR-1290 is overexpressed in colorectal cancer (CRC) and promotes tumor progression. We therefore aimed to explore the potential of circulating miR-1290 as a biomarker for gastrointestinal cancer.. The expression of miR-1290 was analyzed in gastrointestinal tumor cell lines and culture...
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lymph node staging in colorectal cancer: a systematic review and meta-analysis. We aimed to evaluate the diagnostic accuracy of AI models used for detection of lymph node metastasis on pre-operative staging imaging for colorectal cancer.. Studies reporting on the accuracy of radiomics models and/or deep learning for the detection of lymph node. Results: Seventeen eligible studies were identified for inclusion...
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colorectal cancer and adenomas among Iranian population. Thus, the purpose of this case-control study was to investigate the association of DASH score with the risk of CRC and CRA in Iranian adults.. Multivariate logistic regression was performed to assess the association of DASH score and the risk of CRC and CRA.. Results: After adjusting for confounding variables, adherence to the...