Có 20+ tài liệu thuộc chủ đề "Hepatocellular carcinoma"
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Overlapping and unique roles played by ROCK1 and 2 in the modulation of coding and long noncoding RNA expression. Here, a comprehensive comparative bioinformatics analysis of a microarray of an MHCC- 97H cell line overexpressing ROCK1 or ROCK2 was performed.. Compared with MHCC-97H-Con, which was transfected with a null vector, the GO analysis revealed differentially expressed mRNAs (DEmRNAs) in MHCC-97H-ROCK1...
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Exploring the clinical value of preoperative serum gamma-glutamyl transferase levels in the management of patients with. hepatocellular carcinoma receiving postoperative adjuvant transarterial chemoembolization. This study aimed to investigate whether γ -GT levels could be taken as a biomarker to guide the management of PA-TACE in resectable HCC.. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.. 0.05), and patients with...
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Associations between hepatitis B virus infection and risk of colorectal Cancer: a population-based prospective study. However, research concerning the effect of HBV infection on the risk of colorectal cancer (CRC) is rare and inconsistent. This study aims to determine the relationship between HBV infection and new-onset CRC.. Methods: We prospectively examined the relationship between HBV infection and new-onset CRC among...
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chemotherapy in selected populations of patients with treatment-naive unresectable hepatocellular carcinoma exhibiting PD-L1 staining: a multicenter retrospective study. Background: Not all patients with unresectable hepatocellular carcinoma (uHCC) benefit from treatment with immune checkpoint inhibitors and molecular-targeted agents. Methods: Consecutive patients with treatment-naive uHCC exhibiting PD-L1 staining who were treated with pembrolizumab plus lenvatinib plus HAIC (PLH) or pembrolizumab plus lenvatinib...
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hepatocellular carcinoma lesions in patients with Barcelona Clinic Liver Cancer stage. Background: In clinical practice, many hepatocellular carcinoma (HCC) patients in Barcelona Clinical Liver Cancer (BCLC) stage A4 – B1 cannot receive the curative treatments of liver transplantation, resection, and radiofrequency ablation (RFA), which are the recommended options according to liver cancer guidelines. To view a copy of this licence,...
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To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.. HCC, hepatocellular carcinoma. increased age (HR 1.060, P <. higher MELD score (HR 1.100, P <. larger size of the tumor (HR 1.060, P...
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The aim of our present study is to explore the roles and mechanisms of CRBP-1 in regulating liver cancer by using in vitro and in vivo biology approaches.. Methods: The expression level of CRBP-1 was detected using immunohistochemistry in HCC and matching adjacent non-tumorous liver tissues. Results: The low expression of CRBP-1 was observed in HCC tissues compared to the...
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Significance of liver resection for intermediate stage hepatocellular. This study validated the prognostic significance within the Kinki criteria substages and analyzed the role of liver resection in patients with intermediate stage HCC.. Methods: Patients with intermediate stage HCC ( n = 378) were retrospectively subclassified according to the Kinki criteria (B1, n = 123. Patients in substage B1 who underwent...
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Brachytherapy with Iodine-125 seeds for treatment of portal vein-branch tumor thrombus in patients with hepatocellular carcinoma. Background: There is currently no widely-accepted consensus for the management of hepatocellular carcinoma with portal vein tumor thrombus. brachytherapy with iodine-125 seeds for the treatment of hepatocellular carcinoma with portal vein-branch tumor thrombus (PVBTT).. 34 received transarterial chemoembolization (TACE) combined with iodine-125 seeds implanted...
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Methods: The ONCOMINE and the UALCAN databases were used to evaluate the expression of COMMD1 – 10 in HCC and the association of this family with individual cancer stage and tumor grade. Results: The expression of all COMMD family members showed higher expression in HCC tissues than that in normal tissues, and is associated with clinical cancer stage and pathological...
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Identifying novel transcript biomarkers for hepatocellular carcinoma (HCC) using RNA- Seq datasets and machine learning. Background: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death in the world owing to limitations in its prognosis. Results: From the metrics used, it is demonstrated that the efficiency of the known protein biomarkers for HCC is comparatively lower than complete...
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accelerate cell cycle progression in advanced hepatocellular carcinoma. Two lncRNAs, the highly expressed lncRNA in recurrent HCC (HERH)-1 and HERH-4, were upregulated in the advanced HCC cells. HERH-1/4 enhanced proliferation and promoted DNA replication and G1-S transition during the cell cycle in HCC cells. Conclusions: The oncogenic lncRNA HERH-1/4 promoted CCNA2 expression at the transcriptional and post- transcriptional levels and...
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Distinct tumour antigen-specific T-cell immune response profiles at different hepatocellular carcinoma stages. however, the role of tumour-antigen-specific T cell immunity in HCC progression is poorly defined. We characterized CTA- and TAA-specific T cell responses in different HCC stages and investigated their alterations during HCC progression.. The four CTA- and SALL4-specific T cell responses decreased with the progression of HCC, while...
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Gene set enrichment analysis (GSEA) was used to reveal enriched gene sets in the high-risk group. Results: Compared to low-risk group, patients in high-risk group showed reduced disease-free survival (DFS) in the training ( p <. DNA REPAIR ” pathways in the high-risk group. In addition, increased TIL s were observed in the low-risk group compared to the high-risk group....
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MKL1 regulates hepatocellular carcinoma cell proliferation, migration and apoptosis via the COMPASS complex and NF- κ B. Background: Histone modification plays essential roles in hepatocellular carcinoma (HCC) pathogenesis, but the regulatory mechanisms remain poorly understood. Moreover, the activation of NF-kB signaling pathway contributed to the develop- ment of resistance to sorafenib resistance by promoting the expression of CD47 in hepatocellular...
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Down-regulation of EGFL8 regulates migration, invasion and apoptosis of hepatocellular carcinoma through activating Notch signaling pathway. Background: Our previous studies have reported the down-regulation of EGFL8 correlates to the development and prognosis of colorectal and gastric cancer. The present study is carried out to explore the expression pattern and role of EGFL8 in hepatocellular carcinoma (HCC).. Methods and materials: EGFL8...
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Background: Cumulative evidences have been implicated cancer stem cells in the tumor environment of hepatocellular carcinoma (HCC) cells, whereas the biological functions and prognostic significance of stemness related genes (SRGs) in HCC is still unclear.. Time-dependent receiver operating characteristic (ROC) curve, Kaplan-Meier curve and nomogram were used to assess the performance of the gene signature.. Moreover, by univariate and multivariate...
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WGCNA was used to analyze the relationship of the module and the clinical traits. The risk signature was constructed by univariate and multivariate Cox regression analyses and the enrichment analysis of genes in the risk signature was performed by the Intelligent pathway analysis (IPA). The immunophenoscore (IPS) and the tumor immune dysfunction and exclusion (TIDE) were used to estimate the...
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Viral hepatitis associated hepatocellular carcinoma on the African continent, the past, present, and future: a systematic review. Knowledge of the changes in the incidence of viral hepatitis-associated HCC over time and the factors responsible for such changes is key in informing policies for the prevention of viral hepatitis-associated HCC in Africa.. Aim: The study aimed to systematically summarize the changes...