Tìm thấy 20+ kết quả cho từ khóa "Cancer progression"
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During Breast Cancer Progression in Accordance with Chromatin Relaxation. The degree to which chromatin state differences occur in accordance with breast cancer features has not been established.. Methods: We applied a series of unsupervised computational methods to identify chromatin and molecular differ- ences associated with discrete physiologies across human breast cancer tumors..
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SERPINE1 associated with remodeling of the tumor microenvironment in colon cancer progression: a novel therapeutic target. Background: The change of immune cell infiltration essentially influences the process of colorectal cancer development. The infiltration of immune cells can be regulated by a variety of genes.
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LncRNA LINC00342 promotes gastric cancer progression by targeting the miR-545-5p/. Methods: The expression of LINC00342 in GC tissues was evaluated by Quantitative reverse transcription. Silencing of LINC00342 was conducted to investigate the effect of LINC00342 in vitro and in vivo. In addition, a tumor model was used to verify the effect of LINC00342 in tumorigenesis in vivo..
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Therefore, exploration of new mechanisms that promote cancer progression, and rapid and con- cise assessment of disease progression to guide and adjustment of drug therapy are important to prolong patient survival..
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Hence, AURKA could be targeted by miR-490-3p to affect bladder cancer progression. Finally, we further elucidated that LINC00958 facilitated bladder cancer progression via the miR-490-3p/AURKA axis.. Thus, this study is the first to report that AURKA could be regulated by both LINC00958 and miR-490-3p in bladder cancer progression.. Therefore, whether the Wnt/β-catenin pathway or other pathways participate in the LINC00958/miR-490-3p/AURKA axis in bladder cancer needs further exploration.
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The idea that cancer progression is driven by sequential somatic mutations in specific genes has only gained general acceptance in the past 25 years. the advent of the microscope, cancer was believed to be composed of aggregates of mucus or other noncellular matter. By the middle of the nineteenth century, it became clear that tumors were masses of cells and that these cells arose from the normal cells of the tissue in which the cancer originated.
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To our knowledge, the role of FMNL2 in breast cancer progression still re- mains uncovered.. Breast can- cer is closely associated with cell polarity, and dis- rupting polarity proteins affects many stages of breast cancer progression from initiation through metastasis [18]. We speculated that FMNL2 might be implicated in the malignant progression of human breast cancer..
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Epigenetic alterations, including DNA methylation, might initiate and support changes that contribute to the inactivation of tumor-suppressor and other cancer- associated genes in GC [25]. A, the expression of DNMT3A and DNMT3B in GC was queried in StarBase Pan-cancer platform. C, DNMT3B mRNA expression in GC tumor tissues and their adjacent tissues by RT-qPCR. F, transfection efficiency of oe-DNMT3B in GC cells by RT-qPCR.
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Al- tered expression of CDC25A and ALX3 was introduced in vitro and in vivo to access their functions in cervical cancer development.. It was found that CDC25A was highly expressed in the cancer tissues and positively correlated with the tumor staging (Fig. To further validate the correlation between CDC25A and cervical cancer progression, we further explored the CDC25A expression in TCGA-CESC (data of CESC tis- sues) and GTEx-Cervix (data of normal cervical tissues) in the GEPIA database.
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The specific miRNA profile of E-exosomes may also drive the same signal transduction networks in EMT and cancer progression as M-exosomes. miRNA in exosomes plays an important role in the de- velopment and progression of cancer [25]. We established that changes in cellular E/M status translate into unique qualitative rearrangements in the miRNA cargo of exosomes.
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(D) A significant decrease in the expression level of miR-93-5p was detected in bladder cancer cells transfected with miR-93-5p inhibitor. https://doi.org/10.1016/j.. https://doi.org . https://doi.org/10.1038/. https://doi.org X . https://doi.org/10.1186/. MiR-93-5p promotes gastric cancer-cell progression via inactivation of the hippo signaling pathway. https://doi.org/10.1186/s y.. MiR-93-5p promotes cervical cancer progression by targeting THBS2/MMPS signal pathway.
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EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression. https://doi.org/10.1186/s . https://doi.org/10.1093/. https://doi.org/10.1016/j.ccell . org/10.1016/j.tig . doi.org . https://doi.org/10.1038/nrneph.2016.170.
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Liu et al., 2014). that regulates cell proliferation of CSCs, differentiation, apoptosis and cancer progression (Liu et al., 2014). EGFR overexpression is related with therapy resistance, cell proliferation, angiogenesis and CSCs enrichment in BC (Masuda et al., 2012. Czerwinska et al., 2015. It accounts for 25% of all new cancer cases (Bray et al., 2018).
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Prior to POC, computed tomography, ultrasonography, and bone scin- tigraphy were used to assess breast cancer progression.. Either mastectomy or breast-conserving surgery was performed based on the degree of breast cancer progression before and after POC while also considering the patient ’ s wishes [31].. breast cancer. TIL density was evaluated within the biopsy tissue used to diagnose breast cancer. As breast cancer subtypes, ER negative (p <.
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Exosome- transmitted long non-coding RNA PTENP1 suppresses bladder cancer progression
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PI3K/AKT/mTOR: role in breast cancer progression, drug resistance, and treatment. Human adipocytes stimulate invasion of breast cancer MCF-7 cells by secreting IGFBP-2. Improved survival in metastatic breast cancer 1985–2016. Davis (Amaryllidaceae) on human breast cancer cell lines MCF-7 and MDA-MB-231. Breast cancer: current molecular therapeutic targets and new players. The effects of naloxone on human breast cancer progression: in vitro and in vivo studies on MDA.MB231 cells
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Dependency of colorectal cancer on a TGF-beta-driven program in stromal cells for metastasis initiation. Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, et al. Enrichment map profiling of the cancer invasion front suggests regulation of colorectal cancer progression by the bone morphogenetic protein antagonist, gremlin-1. Prognostic significance of stromal GREM1 expression in colorectal cancer.
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In recent years, there has been in- creasing interest related to the role played by immuno- therapy in ovarian cancer progression control.. However, less than 15% of patients with advanced/metastatic ovarian cancer respond to immune checkpoint inhibitors [2, 3].. In other words, this toxic and costly treatment is poten- tially ineffective in the majority of ovarian cancer patients..
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progression in HNSCC. This study was to investigate its expression pattern, clinicopathological significance and biological roles in HNSCC.. Methods: HNSCC data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) was used to indicate the detailed expression pattern and outcome association of FOXD1, while Western Blot assay to detect FOXD1 level in a panel of HNSCC cell lines as well as immunocytochemistry to explore FOXD1 protein abundance and sublocation.
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Prostate cancer. Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin. A mouse model of chronic prostatic inflammation using a human prostate cancer-derived isolate of Propionibacterium acnes. A human prostatic bacterial isolate alters the prostatic microenvironment and accelerates prostate cancer progression.