Có 20+ tài liệu thuộc chủ đề "Prostate cancer"
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Detailed Guide: Prostate Cancer Can Prostate Cancer Be Found Early?. Prostate cancer can often be found early by testing the amount of prostate- specific antigen (PSA), discussed in detail below, in your blood. Prostate cancer may also be found on a digital rectal exam (DRE), in which your doctor inserts a gloved finger into the rectum. Since the use of...
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The present work introduces a new state-of-the-art GPR formulation that considers the stoichiometry of the transcripts (S-GPR). As case of concept, this novel gene-to-reaction formulation was applied to investigate the metabolic effects of the chronic exposure to Aldrin, an endocrine disruptor, on DU145 prostate cancer cells. 2019 Open Access This article is distributed under the terms of the Creative Commons...
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analysis of human prostate microbiota from patients with prostate cancer. Background: Prostate cancer (PCa) is the most common malignant neoplasm among men in many countries.. However, establishing a causal relationship between microbial inflammation and PCa requires a comprehensive analysis of the prostate microbiome. Results: The metagenome and metatranscriptome of tumour and the adjacent benign tissues were assessed in 65 Chinese...
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Modifier locus mapping of a transgenic F2 mouse population identifies CCDC115 as a novel aggressive prostate cancer modifier gene in humans. Background: It is well known that development of prostate cancer (PC) can be attributed to somatic mutations of the genome, acquired within proto-oncogenes or tumor-suppressor genes. RNA-seq were analyzed using cis-eQTL and trait correlation analyses to identify candidate genes...
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The 6-h samples showed activation of the cell cycle inhibitor CDKN1A which might be involved in the secondary response in 12-h samples.. This secondary response predominantly consisted of cell cycle-related changes, with further activation of CDKN1A and inhibition of the transcription factor E2F1 , including downstream target genes, resulting in G1-phase arrest.. Conclusions: FX-9 induced G1-phase arrest of PC-3 cells...
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β -catenin signal pathway in prostate cancer cells. The efficacy of the combination of BZM and mitoxantrone (MTX) in treating prostate cancer remains unknown.. Results: BZM significantly enhanced MTX-induced antiproliferation in vivo and in vitro. BZM significantly attenuated MTX-induced apoptosis. Conclusions: This study demonstrates that BZM enhances MTX-induced anti-tumor effects by inhibiting the Wnt/ β - Catenin signaling pathway in...
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LINC00958 promotes bladder cancer carcinogenesis by targeting miR-490-3p and AURKA. The interaction of LINC00958-miR-490-3p- AURKA was analyzed by luciferase, RIP, and RNA pull-down assays. The biological roles of LINC00958, miR-490-3p, and AURKA in bladder cancer cells were analyzed using CCK8, BrdU, and transwell assays.. Decreased LINC00958 expression repressed bladder cancer progression and downregulation of miR-490-3p accelerated bladder cancer cell progression....
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Exploring the association between use of gonadotropin releasing hormones agonists and prostate cancer diagnosis per se and diabetes control in men with type 2. This study aims to quantify the association of use of GnRH with diabetes control in PCa men with T2DM.. Methods: Nationwide population-based cohort study in the Swedish National Diabetes Register and Prostate Cancer data Base Sweden...
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QUS parameters based on form factor models were used as potential biomarkers of cell death in prostate cancer xenografts.. Results: The average acoustic concentration (AAC) parameter from spherical gaussian and the fluid-filled spherical models were the most efficient imaging biomarker of cell death. Statistical significant increases of AAC were found in the combined treatment groups: 246 kPa + 40 min,...
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Role of miR-182/PDCD4 axis in aggressive behavior of prostate cancer in the African Americans. In this study, we investigated the role of miR-182 in racial disparity in prostate cancer.. Results: We found significantly increased levels of miR-182 in prostate cancer tissues compared to BPH. Also, miR- 182 shows increased expression in AA prostate cancer cell line and tissue samples compared...
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Out-of-pocket medical expenses compared across five years for patients with one of five common cancers in Australia. Background: Patient medical out-of-pocket expenses are thought to be rising worldwide yet data describing trends over time is scant. We evaluated trends of out-of-pocket expenses for patients in Australia with one of five major cancers in the first-year after diagnosis.. Medicare claims data...
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The self-descriptions “ cancer survivor ” (16.8. cancer conqueror ” (10.9%) and. Cancer survivor ” was associated with high perceived disease severity (OR . Cancer survivor ” and “ cancer conqueror ” were related to high benefit finding (OR OR:. respectively), and only “ cancer conqueror ” was associated with high well-being (OR . Identification as “ victim ” was...
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Perceived barriers to the adoption of active surveillance in low-risk prostate cancer: a qualitative analysis of community and academic urologists. The aim of this study is to describe barriers to urologists ’ recommendation of active surveillance in low-risk prostate cancer and explore variation of barriers by setting.. Conclusions: Despite national and international recommendations, both academic and community urologists note a...
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A deeper understanding of the tumour microenvironment is needed to identify the key drivers of disease progression and reveal novel therapeutic opportunities.. Results: In this study, the experimental enrichment of selected cell-types, the development of a Bayesian inference model for continuous differential transcript abundance, and multiplex immunohistochemistry permitted us to define the transcriptional landscape of the prostate cancer microenvironment along...
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Geographic disparities in Saskatchewan prostate cancer incidence and its. Background: Saskatchewan has one of the highest incidence of prostate cancer (PCa) in Canada. First, the objective of this study is to estimate the PCa standardized incidence ratio (SIRs) in Saskatchewan stratified by PCa risk-level. Second, this study identifies clusters of higher than and lower than expected PCa SIRs in Saskatchewan....
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Results: The EBV/HPV coinfection was reported in 14.9% of patients in the case group and 7.5% of the control subjects. However, the highest percentage of HPV genome integration was found in the HPV/EBV-coinfected PCa group (8/10. Also, the mean expression levels of inflammatory factors (IL-17, IL-6, TNF- α , NF- κ B, VEGF, ROS, and RNS), anti-apoptotic mediators (Bcl-2 and...
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Hypoxia has been shown to play a role in the development of the resistance to radiation and chemotherapeutic treatment in various tumor types (Zhong et al., 1999;. Koyasu et al., 2018).. Ubiquitin-proteasome pathways play a crucial role in the cellular process by regulating the expression of key proteins involved in oncogenesis and cell cycle progression (Shen et al., 2013. Chen...
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doi:10.3906/kim-2008-56. It ranks second among the diseases that cause human deaths in the world. In 2017, Domracheva et al. In 2020, Erşatır et al.. synthesized 8 new coumarin-selenophene hybrid compounds and investigated the anticancer activities of these compounds and coumarins with starting compounds in the MCF-7 breast cancer cell line. The prepared compounds are screened for their anticancer activity against...
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The concentration of CAP in pepper is one of the essential factors that define its competitive value [11] and thus the need for rapid, high throughput analysis at a reduced cost has placed a high demand for developing efficient analytical methods for food analysis [12]. The proposed method was efficiently applied for the extraction and quantitation of the three capsaicinoids...
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prostate cancer in Kurdistan Province-Iran:. Background: The population-based survival rate is affected by the quality and effectiveness of health care systems.. Overall, the survival of prostate cancer (PC) patients has improved over the past two decades worldwide. This study aimed to determine the overall survival rate and correlate it with the prognostic factors in patients with PC diagnosed in Kurdistan...