Tìm thấy 11+ kết quả cho từ khóa "NF-κB signaling"
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Described effects of FX-9 like in- duction of cell cycle inhibitor CDKN1A, activation of NF-κB signaling pathway and senescence can be caused by DNA damage . org/10.1186/s y.. https://doi.. org/10.1002/adsc.201600169.. https://doi.org/10.1016/j.bmcl . https://doi.org/10.1016/S . https://doi.org/1 0.1016/j.ejmech . https://doi.org/10.1093/carcin/bgt133.. https://doi.org/10.1016/j.ejmech . https://doi.org/10.4062/biomolther.2018.199.. org/10.3390/ijms20225567.. https://doi.org/10.1038/nm0103-140..
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These results demonstrated significant alteration of the COMPASS complex and NF-kB signaling pathways caused by MKL1 silencing in hepatocellular carcinoma cells, which indicted the medi- ating roles of the COMPASS/NF-kB axis in HCC patho- genesis promoted by MKL1..
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Ivermectin induces apoptosis of ESCC cells through NF‑κB pathway. The NF-κB signaling pathway is involved in ESCC car- cinogenesis and progression and is hyperactivated in ESCC cells and promotes cell survival. Subsequently, we also found that the phosphorylation of IκBα, an upstream regulatory molecule of NF-κB pathway, was inhibited in ESCC cells after ivermectin treatment (Fig. Taken together, these results indicated that ivermec- tin induces apoptosis of ESCC cells through NF-κB pathway..
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Uncontrolled, constitutive activation of the prosurvival NF-κB signaling pathway was observed in the ABC DLBCL subtype but not in GCB DLBCL cases (Davis et al., 2001). Indeed, CARD11 mutations associated with activation of NF-kB were identified in approximately 10% of ABC DLBCL cases (Lenz et al., 2008) (Figure 1A). CD79A and CD79B) may contribute to this oncogenic activation (Davis et al., 2010) (Figure 1D).
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Neuronal NF- κ B activation can stabilize intracellular calcium con- centrations under ischemia-like conditions (Barger et al., 1995. Barger and Mattson, 1996), possibly via induction of several different genes, including those encoding calcium-binding proteins and glutamate receptor (Cheng et al., 1994. Gary et al., 2000).. 6.3 Role of NF- κ B in Alzheimer Disease (AD). Recent studies suggest that dysregulation of NF-κB signaling might be involved in the pathogenesis of AD.
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The results of KEGG pathway enrichment analysis showed that those 1966 common DEGs in three populations were enriched in the following pathways: protein processing in endoplasmic reticulum (57 genes), NF-κB signaling pathway (25 genes), antigen processing and presentation (16 genes), osteoclast differentiation (22 genes), Toll and Imd signaling pathway (27 genes), fluid shear stress and atherosclerosis (32 genes), necroptosis (30 genes), and apoptosis (19 genes) (Fig.
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NF-κB Nuclear factor κB NIK NF-κB–inducing kinase NGF Nerve growth factor PD Parkinson’s disease SOD Superoxide dismutase SRD Signal response domain TNF Tumor necrosis factor. 4 Regulation of NF-κB Signaling. 5 Role of NF-κB Signaling in the CNS. 5.1 NF-κB in the CNS. 5.2 Activators and Inhibitors of NF- κ B in the CNS. 5.3 NF- κ B–Regulating Genes in the CNS. 5.6 Role of NF- κ B in Neuroprotection. 5.7 Role of NF- κ B in Glial Cells. 6 Role of NF- κ B in Brain Diseases. 6.2 Role of NF- κ B in Seizures
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Comparison between our results and those of previ- ous studies suggests that the selected circRNAs might play an important role in the signaling pathways during different stages of SF development in AFWS. Wnt, Hedgehog and NF-κB/Edar pathways were found to be indispensable in the process of hair follicle growth [52].. EDA/Edar/NF-κB signaling pathways play an important role in the initiation and maintenance of PF placodes [55]..
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Previous studies have shown that NF-κB signaling pathway, one of the most import- ant pathways, plays an important role during TGEV- induced inflammatory response . There- fore, changes in the expression levels of genes, which related in NF- κ B signaling pathway, might influence the TGEV-induced inflammatory response. The differ- entially expressed lncRNAs may affect TGEV-induced. BMC Genomics Page 6 of 13. inflammatory response by affecting NF-κB signaling pathway.
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BEX2 has been shown that it activates the NF-kB signaling pathway in breast cancer cells (Naderi et al., 2007), promotes the human glioblastoma cells proliferation via the NF-κB signaling pathway (Meng et al., 2014). In this study, NF-κB is one of the prominent enriched pathway. The most enriched gene among them is Tnf, which plays a central role in the development of the immune system. Similarly, Bcl2a1d, from NF-kB pathway is related to apoptotic process (Cartagena et al., 2013).
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IL1R1 combines with IL-1 on the cell surface which can upregulate inflammation and affect NF-κB signaling (Rhodes et al., 2015). NF- κB plays a key role in maintaining liver homeostasis by regulating the transcription of genes (Majidinia et al., 2017). NF-κB can regulate the expression of cyclin D1 (Guttridge et al., 1999) and has antiapoptotic functions (Luedde and Schwabe, 2011). increased apoptosis led to less cell proliferation in the liver of IL-1R1 KO mice.
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These data suggest that NF-κB is a potential upstream regulator of TRIM27 in RCC. Iκbα has been identified as the major regulator of the NF-κB pathway [19], and dissociation of NF-κB from Iκbα is a critical step in translocation to the nucleus. 3 oeTRIM27 rescues the function of TRIM27 in siTRIM27-transfected cells. The proliferations of Caki-2 and 786 – 0 cells transfected with siTRIM27, oeTRIM27, or siTRIM27 + oeTRIM27 at and 48 h respectively.
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Consistently, we find TGEV infection upregulates RIG-I and TLR3 and induces the activation of NF-κB pathway in IPEC-J2 cells, indicating TGEV. a Venn diagram shows the number of overlap genes in target genes of differentially expressed miRNAs. study, TGEV infection activates the Jak-STAT signaling pathway in IPEC-J2 cells, consistent with previous studies..
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Out of 14 “NF-κB-dependent” genes re- vealed in the current study, there were 10 genes listed in the “Gilmore’s database”. When the overlap of genes regulated by either p53 or NF-κB was analyzed using the abovemen- tioned reference lists, there were 110 genes hypothetic- ally co-regulated by p53 and NF-κB, including 6 genes present in the “top 116” subset (namely BAX , CDKN1A , CSF1 , FAS , KITLG , PRDM1.
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In the present study, we postulated that miR-214, ROCK1, and NF-κB may be involved in DEX-mediated protective ef- fects against CIRI in rats.
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Đoạn gen sau đó được nhân bội bằng phương pháp PCR sử dụng cặp mồi NF-κB p65-F, NF-κB p65-R có chứa vị trí cắt của enzyme giới hạn BamHI và EcoRI. Kích thước này tương ứng với kích thước của đoạn gen mã hóa NF-κB p65 cần nhân dòng. Kết quả này chỉ ra rằng, gen mã hóa cho NF-κB p65 đã được nhân dòng thành công bằng kỹ thuật PCR sử dụng cặp mồi đặc hiệu NF-κB p65-F, NF-κB p65-R.. Kết quả PCR đoạn gen mã hóa nhân tố phiên mã NF-κB p65.
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Additionally, NF-κB is considered as a crucial downstream transcription factor of the IL-17A signaling pathway [18], and NF-κB path- way has been suggested to involve in many essential bio- logical processes, such as immune inflammatory response and cell apoptosis [19].
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Two different types of signaling cascades are initiated after binding of TNFα to its receptors, TNFR1 and TNFR2 (Grel et al., 1994). The formation of complex-1 is known to be responsible for TNF-mediated activation of p38, JNKs and NF-kB. Therefore, activation of this promotes apoptosis (Micheau and Tschopp, 2003), necroptosis (He et al., 2009) and the activation of NF-kB (Boone E et al., 1998. Ozes et al., 1999. Fan et al., 2010)..
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However, current knowledge of NF-κB activation in the CNS is very limited.. 5 Role of NF- κ B Signaling in the CNS 5.1 NF- κ B in the CNS.
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Tác nhân kích hoạt NF- kappa B và gene gây ung thư điều. hòa bởi NF-kappa B.. Kích hoạt NF-kappa B bởi các tác nhân viêm nhiễm, hóa chất gây hay thúc đẩy ung thư, protein virút, hóa chất dùng trong hóa trị liệu, và phóng xạ gamma.. quá trình tồn tại, sinh trưởng, tăng sinh mạch máu, phản ứng viêm,. xâm lấn và di căn của tế bào được điều hòa bởi NF-kappa B được kích hoạt..