Có 11+ tài liệu thuộc chủ đề "Esophageal squamous cell carcinoma"
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A total of 218 scRNA-seq libraries were obtained from 88 cells exposed to 12 Gy (KYSE-180-12 Gy), 89 exposed to 30 Gy (KYSE-180- 30 Gy), and 41 parental KYSE-180 cells not exposed to FIR. Biological experiments showed that KYSE-180 cells became radioresistant after FIR. PCA analysis of scRNA-seq data showed KYSE-180, KYSE-180-12 Gy and KYSE-180-30 Gy cells were discrete away...
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Results: P-spline regression revealed a dependence of patient outcomes on GTVp, with 30 cm 3 being an optimal cut-off for differences in overall and progression-free survival (OS, PFS). GTVp ≥ 30 cm 3 was a negative independent prognostic factor for OS and PFS. 30 cm 3 , no significant survival differences were observed among the 3 treatments. For GTVp ≥...
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LINC00958 promotes bladder cancer carcinogenesis by targeting miR-490-3p and AURKA. The interaction of LINC00958-miR-490-3p- AURKA was analyzed by luciferase, RIP, and RNA pull-down assays. The biological roles of LINC00958, miR-490-3p, and AURKA in bladder cancer cells were analyzed using CCK8, BrdU, and transwell assays.. Decreased LINC00958 expression repressed bladder cancer progression and downregulation of miR-490-3p accelerated bladder cancer cell progression....
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The performance of the radiomics models was assessed by its discrimination, calibration and clinical usefulness with independent validation.. When ComBat correction was used, the performance of 2D models was better ( p = 0.0059) in the training cohort, and significantly better ( p <. 0.0001) in the validation cohort. The calibration curve of the radiomics model demonstrated good agreement between...
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Here, we report that ubiquitin specific peptidase 3 (USP3) promotes proliferation and metastasis of esophageal squamous cell carcinoma (ESCC) cells by mediating deubiquitination of Aurora A. In this mechanism, USP3 leads to suppression of Aurora A ubiquitination, resulting less proteasome degradation. deubiquitinated mimetic K143R of Aurora A and found that K143R significantly promoted the proliferation and invasion of ESCC cells...
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Methods: Published clinical trials in the PubMed, Medline, Embase databases on PD-1 inhibitors for the treatment of ESCC were searched, along with an additional search on abstracts from the American Society of Clinical Oncology (ASCO) and European Society for Medical Oncology (ESMO) from inception to September 2021. P = 0.01) of advanced ESCC patients, especially significantly prolonged the OS in...
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Risk factors for esophageal squamous cell carcinoma and its histological precursor lesions in China: a multicenter cross- sectional study. In this study, we, therefore, aimed to describe the risk factors associated with ESCC and its precursor lesions.. Drinking well and surface water, salty diet, and positive family history of cancer were the common risk factors for esophagitis, LGIN and HGIN/ESCC....
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Overexpression of UBE2C in esophageal squamous cell carcinoma tissues and molecular analysis. Methods: In this study, we conducted a comprehensive evaluation of the UBE2C expression in ESCC by collecting the protein and mRNA expression data (including in-house RNA-seq, in-hosue immunohistochemistry, TCGA-GTEx RNA-seq and tissue microarray) to calculate a combined standardized mean difference (SMD) and summary receiver operating characteristic curve (sROC)....
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Background: A plethora of prognostic biomarkers for esophageal squamous cell carcinoma (ESCC) that have hitherto been reported are challenged with low reproducibility due to high molecular heterogeneity of ESCC. Forty-eight biomarkers linked to recurrence or prognosis of ESCC were used to construct a molecular interaction network based on NetBox and then to identify the functional modules. Publicably available mRNA transcriptome...
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Results: Our results determined that ivermectin significantly inhibited the proliferation of ESCC cells in vitro and in vivo. Furthermore, we found that ivermectin markedly mediated mitochondrial dysfunction and induced apoptosis of ESCC cells, which indicated the anti-proliferative effect of ivermectin on ESCC cells was implicated in mitochondrial apoptotic pathway. How- ever, few candidate drugs that have long-term benefits for ESCC...
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Mmbaga 5 , Katherine Van Loon 1 and of the African Esophageal Cancer Consortium (AfrECC). Treatment outcomes that will be evaluated include overall survival, quality of life (QOL) and safety.. 18 years old) who present to participating sites with a histopathologically-confirmed or presumptive clinical diagnosis of ESCC based on endoscopy or barium swallow will be recruited to participate. Key clinical...