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Mitochondrial dysfunction

Tìm thấy 12+ kết quả cho từ khóa "Mitochondrial dysfunction"

Ivermectin induces apoptosis of esophageal squamous cell carcinoma via mitochondrial pathway

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Furthermore, we found that ivermectin markedly mediated mitochondrial dysfunction and induced apoptosis of ESCC cells, which indicated the anti-proliferative effect of ivermectin on ESCC cells was implicated in mitochondrial apoptotic pathway.

Proteome analysis identified proteins associated with mitochondrial function and inflammation activation crucially regulating the pathogenesis of fatty liver disease

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It was presumed that mitochondrial dysfunction was one of the underlying reason for the onset of fatty liver disease in dairy cattle (Fig. confirmed, mitochondrial dysfunction can inhibit mito- chondrial β-oxidation and thereby cause fatty liver and in- crease lipid toxic metabolites, which might in turn exert adverse effects on mitochondrial function, resulting in a vicious cycle [18–20].

Cobalt chloride alters mitochondrial function of in vitro cultured cardiomyocytes in a dose-dependent manner

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Effects of CoCl 2 on mitochondrial cardiolipin were tested by the NAO fluorescence kit. NAO intensity in H9C2 cells.. The decrease in the number and structure of cardiolipin leads to mitochondrial dysfunction and is closely associated with a large number of diseases [14].. CoCl 2 Strongly Altered Cardiac Mitochondrial Function. The images of H9C2 cells stained mitochondrial dyes.. Control: cells were cultured in normal.

Independent impacts of aging on mitochondrial DNA quantity and quality in humans

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In mitochondrial diseases, a compensatory increase in mtDNA copy number via mitochondrial biogenesis may effectively compensate for heteroplasmic mtDNA mutations and mitochondrial dysfunction [65 – 67]. Thus, the observed age-related copy number decrease may result in a weaker copy num- ber buffering effect during aging.

Sarcopenia Age-Related Muscle Wasting and Weakness: Mechanisms and Treatments P16

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Some of the most compelling data examining the role of mitochondrial dysfunc- tion in age-related muscle atrophy has been the studies examining the co-localiza- tion of mitochondrial dysfunction and mitochondrial DNA (mtDNA) damage with focal regions of fiber atrophy and breakage along the length of individual muscle fibers in aged muscle (Lee et al.

Naringin effectively protects cardiomyocytes against Hypoxia/Reoxygenation injury

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Naringin Ameliorates Mitochondrial Dysfunction in HR-subjected H9C2 Cells Mitochondria are powerhouse of cells and play important roles in cellular biological process.. In this study, the effects of NAR on mitochondria of H9C2 cells were assessed via. mitochondrial cardiolipin contents and mitochondrial membrane potential indexes.. NAO intensity in H9C2 cells..

Sarcopenia Age-Related Muscle Wasting and Weakness: Mechanisms and Treatments P22

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Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. British Journal of Cancer . Regulators of cell death. BCL-2 gene family and the regulation of programmed cell death. Reactive oxygen species and the regulation of cell death by the Bcl-2 gene family. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Mitochondrial control of cell death.

Anesthetic management of a pediatric patient with Electron Transfer Flavoprotein Dehydrogenase deficiency (ETFDH) and acute appendicitis: Case report and review of the literature

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Anesthetic considerations in patients with mitochondrial defects. Stiegler MP, Neelankavil JP, Canalesm C, et al. Scalco RS, Gardiner AR, Pitceathly RDS, et al. Vanlander AV, Jorens PG, Smet J, et al. Propofol Infusion Syndrome in the ICU. Dhananjay DN, Sundar S, Thomas KP, et al. Terkawi AS, Wani TM, Al-Shuaibi KM, et al. Trevisan CP, Accorsi A, Morandi LO, et al. surgical and anesthetic management of patients with mitochondrial dysfunction. Parikh S, Russell Saneto DO, Falk MJ, et al.

Transcriptome analysis reveals mechanism underlying the differential intestinal functionality of laying hens in the late phase and peak phase of production

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This is accomplished by the respira- tory chain in the inner mitochondrial membrane [38], comprising five complexes including complex I (NADH-CoQ dehydrogenase), complex II (succinate- CoQ dehydrogenase), complex III (reduced CoQ- cytochrome c reductase), complex IV (cytochrome C oxidase) and complex V (ATP synthase) (Additional file 4). Consequently, mitochondrial dysfunction could re- strict nutrient absorption and metabolism, therefore favoring the declined performance of laying hens.

Differential effects and mechanisms of local anesthetics on esophageal carcinoma cell migration, growth, survival and chemosensitivity

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S2 to S4), suggesting that proliferation inhibition by local anesthetics might be due to their ability in inducing mitochondrial dysfunction, oxidative stress and damage in esophageal carcinoma cells..

Neurochemical Mechanisms in Disease P38

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Quintanilla RA, Johnson GVW (2009) Role of mitochondrial dysfunction in the pathogenesis of Huntington’s disease. Reddy PH, Mao P, Manczak M (2009) Mitochondrial structural and functional dynamics in Huntington’s disease. N, Raskin S, Werneck LC, Junior WM, Tumas V (2008) Huntington’s disease-like 2 in Brazil – report of 4 patients.

Neurochemical Mechanisms in Disease P64

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In this regard, it is been suggested that mitochondrial dysfunction, acting in concert with cytoskeletal pathology, serves to increase redox-active heavy metals and initiates a cascade of abnormal events culminating in AD pathology (Castellani et al., 2004)..

Chapter 049. Sexual Dysfunction (Part 8)

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Basson R: Recent advances in women's sexual function and dysfunction.. Bhasin S et al: Sexual dysfunction in men and women with endocrine. Lancet PMID: 17307107]. Burnett AL: Erectile dysfunction. Davis SR et al: Endocrine aspects of female sexual dysfunction. Doggrell SA: Comparison of clinical trials with sildenafil, vardenafil, and tadalafil in erectile dysfunction. Pauls RN et al: Female sexual dysfunction: principles of diagnosis and therapy.

Altered expression of microRNAs in the rat diaphragm in a model of ventilatorinduced diaphragm dysfunction after controlled mechanical ventilation

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Interactions between Cytosolic Phospholipase A2 Activation and Mitochondrial Reactive Oxygen Species Production in the Development of Ventilator-Induced Diaphragm Dysfunction. Tang H, Smith IJ, Hussain SN, Goldberg P, Lee M, Sugiarto S, et al

Chapter 049. Sexual Dysfunction (Part 6)

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Female Sexual Dysfunction. Female sexual dysfunction (FSD) has traditionally included disorders of desire, arousal, pain, and muted orgasm. The associated risk factors for FSD are similar to those in males: cardiovascular disease, endocrine disorders, hypertension, neurologic disorders, and smoking (Table 49-2).. Table 49-2 Risk Factors for Female Sexual Dysfunction. Liver and/or renal failure

Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle

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Expression of the mitochondrial genome in HeLa cells

A new method for long-read sequencing of animal mitochondrial genomes: Application to the identification of equine mitochondrial DNA variants

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Large variation in the ratio of mitochondrial to nuclear mutation rate across animals: implications for genetic diversity and the use of mitochondrial DNA as a molecular marker.. Frequency and pattern of heteroplasmy in the complete human mitochondrial genome. Exceptionally high density of NUMTs in the honeybee genome. Continued colonization of the human genome by mitochondrial DNA. Mitochondrial DNA insertions in the nuclear horse genome.

The plastid and mitochondrial genomes of Eucalyptus grandis

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We used mitochondrial genome scaffolds from the Joint Genome Institute assembly of the E. grandis nuclear genome to perform a reference-based assembly of the mitochondrial genome from Illumina whole genome sequencing (WGS) data. The aver- age coverage of the WGS reads across the mitochondrial genome is ~ 700, with regions of ten times the average coverage representing overlaps between the plastid and mitochondrial genomes (Fig. 1b) Repeat elements make up 2.47% of the E.

Chapter 049. Sexual Dysfunction (Part 5)

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Sexual Dysfunction. Male Sexual Dysfunction: Treatment. Patient and partner education is essential in the treatment of ED. In goal- directed therapy, education facilitates understanding of the disease, results of the tests, and selection of treatment. Discussion of treatment options helps to clarify how treatment is best offered and stratify first- and second-line therapies.

Rapid evolutionary divergence of diploid and allotetraploid Gossypium mitochondrial genomes

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Cost of having the largest mitochondrial genome:. evolutionary mechanism of plant mitochondrial genome. Determination of the melon chloroplast and mitochondrial genome sequences reveals that the largest reported mitochondrial genome in plants contains a significant amount of DNA having a nuclear origin. The mitochondrial genome of Malus domestica and the import-driven hypothesis of mitochondrial genome expansion in seed plants.