Tìm thấy 20+ kết quả cho từ khóa "Progression-free survival"
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Impact of the line of treatment on. progression-free survival in patients treated with T-DM1 for metastatic breast cancer. We wished to determine if the line of treatment in which T-DM1 is administered has an impact on progression-free survival (PFS) and in particular, if prior treatment with capecitabine/lapatinib or pertuzumab modifies PFS of further treatment with T-DM1..
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For mCRC patients with early disease progression in the first-line setting, the efficacy of second-line chemother- apy is modest, regardless of whether BBP or other strat- egies have been employed. mCRC: Metastatic colorectal cancer. Progression-free survival and overall survival by second-line chemotherapy regimen..
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Evaluating progression-free survival as a surrogate outcome for health- related quality of life in oncology: a systematic review and quantitative analysis. https://doi.org/10.1001/ja mainternmed.2018.4710.. Progression-free survival is a suboptimal predictor for overall survival among metastatic solid tumour clinical trials. https://doi.org/10.1016/j.ejca . https://doi.org/10.1038/bcj.2016.101..
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Primary outcome measures were overall survival and progression-free survival and prognostic factors of overall survival. Kaplan Meier method for overall survival and progression-free survival. Cox regression analysis was performed for the determination of the prognostic factors for overall survival.. The median follow-up and median overall survival of study cohort were 17 months and 18.5 months. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/..
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Table 3 Univariate and multivariate Cox regression model analysis of factors predicting progression-free survival of the patients with advanced stage ovarian cancer. Serum albumin lt. BMI at admission . NRI at admission .
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Schouten HC et al: High-dose therapy improves progression-free survival and survival in relapsed follicular non-Hodgkin's lymphoma: Results from the randomized European CUP trial. Syrjala KL et al: Recovery and long-term function after hematopoietic cell transplantation for leukemia or lymphoma
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Abbreviations: HR Hazard ratio, CI Confidence interval, OS Overall survival, PFS Progression-free survival, DMFS Distant metastasis-free survival, LRFS Locoregional relapse-free survival, ADC Apparent diffusion coefficient, IC Induction chemotherapy, RT Radiotherapy, ΔADC% Percentage change in ADC value after induction chemotherapy.
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There is no standard maintenance therapy to prolong time to progression.. Oral prednisone maintenance therapy was effective in a single trial. Ongoing studies are evaluating maintenance thalidomide and lenalidomide to prolong progression-free survival post-transplant.. Relapsed myeloma can be treated with novel agents including lenalidomide and/or bortezomib. These agents target not only the tumor cell but also the tumor cell–bone marrow interaction and the bone marrow milieu.
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The oncological outcome in general for the patients in this study with a 5-year overall survival rate of 71%, a 5- year disease-specific survival rate of 86% and a 5-year progression-free survival rate of 72% is comparable or even superior to available literature and demonstrates the improvement of the overall survival in the treatment of advanced-stage CUPs. 2 Association of time span from surgery to adjuvant therapy with progression free survival.
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The expression of KLRG1 is correlated with. immunotherapy response and overall survival in LUAD patients. Among them, we found that KLRG1 had the most significant correlation with the Table 2 Association of KLRG1 expression levels with. Table 3 Statistically significant associations of KLRG1 expression and other clinicopathologic variables with progression-free survival.
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Kaplan-Meier curves for progression-free survival and overall survival by histology in uncommon non-small cell lung cancer group. Kaplan-Meier curves for progression-free survival and overall survival by histology in matched common non-small cell lung cancer group.. Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer. Atezolizumab for first-line treatment of PD-L1-selected patients with NSCLC.
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Vogl et al reported that the progression-free survival rate at 1 and 2 years were much higher than ours. In the Vogl et al’s study, the progression- free survival rate for patients treated with MWA of 1, 2, 3 years were and treated with RFA were and 90.6%, respectively (p . The difference was not significant between the two groups (p . We confirmed that the prognostic factors of DFS were age (<.
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In the Asia-Pacific study comparing sorafenib versus placebo described above [11], the statistically significant improvement (p = 0.014) did not reach the same magni- tude of benefit as in the SHARP trial [4], despite the similarity in the hazard ratios of overall survival, progression-free survival, and time to progression.
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This association was also observed for progression-free survival in the TCGA BRCA primary tumor cohort (Additional file 12: Fig. Alternatively, in the present study, lower tissue ST14-associated methylation (i.e., GAM sta- tus) was associated with a higher risk of death, providing a surrogate for risk evaluation in BC. Furthermore, a higher ST14 expression level was significantly associated with a low GAM status in the training TCGA and the two valid- ation cohorts.
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Chemotherapy palliates symptoms, improves the quality of life, and improves survival in newly diagnosed patients with stage IV NSCLC, particularly in patients with good performance status. However, patients with a poorer performance status seem to obtain less benefit.. Bevacizumab, a monoclonal antibody to VEGF, improves response rate, progression-free survival, and overall survival of patients with advanced disease when combined with chemotherapy (paclitaxel/carboplatin).
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Among the 41 studies, 35 studies reported the relationship between the tumor length of EC and OS, 10 studies reported disease-free survival (DFS), 2 reported progression-free survival (PFS reported cancer-specific survival (CSS) [55] and 1 reported disease-specific survival (DSS) [20].. Eighteen studies used a tumor length cut-off value of ≥5, and 23 studies used a tumor length cut-off value of <.
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Verweij J et al: Progression-free survival in gastrointestinal stromal tumors with high-dose imatinib: Randomized trial. Burgert EO et al: Multimodal therapy for the management of nonpelvic localized Ewing's sarcoma of bone: IESS II. Cangir A et al: Ewing's sarcoma metastatic at diagnosis—results and comparisons of two intergroup studies. Jablons D et al: Metastasectomy for soft tissue sarcoma—further evidence for efficacy and prognostic indicators.
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Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: a german breast group 26/. https://doi.org/10.1200/JCO . Trastuzumab beyond progression for HER2 positive metastatic breast cancer: progression-free survival on first-line therapy predicts overall survival impact. https://doi.org/10.1007/s z.. The Japanese breast Cancer society clinical practice guidelines for systemic treatment of breast cancer, 2018 edition.
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Tumor response and progression-free survival as potential surrogate endpoints for overall survival in extensive stage small-cell lung cancer: findings on the basis of North Central Cancer Treatment Group trials. https://doi.org/10.1002/cncr.25526.. Brain metastases in small cell lung cancer.. Stereotactic radiosurgery alone for small cell lung cancer: a neurocognitive benefit? Radiat Oncol. https://doi.org X-9-218..
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Thus, a better understanding of the composition of the Table 3 Crude and adjusted Hazards Ratios for Carcinosarcoma progression-free survival (PFS) estimated by univariate analysis and multivariate analysis.