Có 19+ tài liệu thuộc chủ đề "Bladder cancer"
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Epigenetic interplay between methylation and miRNA in bladder cancer: focus on isoform expression. Further, overall survival analysis on the 136 combinations based on methylation and miRNA, high and low expression groups resulted in 13 combinations associated with survival. Keywords: Epigenetics, Bladder cancer, Methylation, miRNA, Isoform expression. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.. The Creative Commons Public Domain...
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Full list of author information is available at the end of the article. Interestingly, it is observed that following NAC, approxi- mately 20 to 40% of patients have no residual urothelial cancer cells on histological examination of the RC speci- men and on ePLND [9 – 11]. The 10 – 15% of patients who develop distant metastases early after NAC...
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LINC00958 promotes bladder cancer carcinogenesis by targeting miR-490-3p and AURKA. The interaction of LINC00958-miR-490-3p- AURKA was analyzed by luciferase, RIP, and RNA pull-down assays. The biological roles of LINC00958, miR-490-3p, and AURKA in bladder cancer cells were analyzed using CCK8, BrdU, and transwell assays.. Decreased LINC00958 expression repressed bladder cancer progression and downregulation of miR-490-3p accelerated bladder cancer cell progression....
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The least absolute shrinkage and selection operator Cox regression were used to develop the m6A-RLPS. Fifty-one prognostic m6A-related lncRNAs were screened using univariate Cox regression analysis. m6A-related lncRNAs identification. The Wil- coxon rank-sum test was used to compare the expres- sion levels (visualized using heatmaps) of the prognostic m6A-related lncRNAs between tumor and normal tissues.. Heatmaps were created using the...
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Identification of a novel metabolism-related gene signature associated with the survival of bladder cancer. In this study, we attempted to construct a novel metabolism-related gene (MRG) signature for predicting the survival probability of BC patients.. Results: In the present study, 27 differentially expressed MRGs were identified, most of which presented mutations in BC patients, and LRP1 showed the highest mutation...
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The effect of hypoxia on PD-L1 expression in bladder cancer. Both hypoxia and an immunosuppressive TME are targetable independent negative prognos- tic factors for bladder cancer. Therefore we sought to investigate whether hypoxia is associated with upregulation of PD-L1 in the disease.. Materials and methods: Three human muscle-invasive bladder cancer cell lines (T24, J82, UMUC3) were cultured in normoxia (20%...
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Compared with that in the low-risk group, the overall survival (OS) of patients in the high-risk group was significantly lower ( P <. characteristic (ROC) curve analysis verified the predictive ability of the model. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to...
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PD-L1 for tailoring therapeutic strategies in bladder cancer. The prognostic role of PD-L1 in bladder cancer has been investigated in previous studies, but the results remain inconclusive. Results: Patients in the PD-L1-low-exhausted group had the worst prognosis and showed the worst antigen- presenting cell (APC) immunosuppression status. The PD-L1-low-exhausted group showed the highest amount of infiltration by macrophage M2 cells,...
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Significance of KDM6A mutation in bladder cancer immune escape. Here, we explored the potential role of KDM6A in regulating the antitumor immune response.. The frequency o KDM6A mutations in the TCGA and ICGC datasets was 25.97 and 24.27%, respectively. In addition, KDM6A mutation was associated with a lower number of tumour-infiltrating immune cells (TIICs) and indicated a state of immune...
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Cancer-specific survival by stage of bladder cancer and factors collected by Mallorca Cancer Registry associated to survival. Background: Information about survival by stage in bladder cancer is scarce, as well as about survival of non- invasive bladder cancer. The aims of this study are: 1) to find out the distribution of bladder cancer by stage. 2) to determine cancer-specific survival...
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microenvironment-related seven-gene signature for predicting prognosis in bladder cancer. Currently we aimed to establish a prognostic model based on TME-related gene expression for guiding clinical management of BLCA.. Bladder cancer (T24, EJ-m3) and bladder uroepithelial cell line (SVHUC1) were used for genes validation. Furthermore, seven hub genes (ACAP1, ADAMTS9, TAP1, IFIT3, FBN1, FSTL1, COL6A2) were screened out to establish a...
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Finally, GSEA showed that gene sets related to the extracellular matrix (ECM), stromal cells and epithelial-mesenchymal transition (EMT) were enriched in the high-risk group. In the low-risk group, we found a number of immune-related pathways in the enriched pathways and biofunctions.. validate the accuracy of the risk signature (Fig. The clinical information of BC patients in the TCGA and GSE31684...
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We aim at investigating radiomic features ’ value in predicting the TMB status of BLCA patients.. Radiomic features extracted from the volume of interest of preoperative pelvic contrast-enhanced computed tomography (CECT) were obtained for each case. Unsupervised hierarchical clustering analysis was performed based on radiomic features. Sequential univariate Logistic regression, the least absolute shrinkage and selection operator (LASSO) regression and...
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The aim of this research was to develop and validate an mRNA-based signature for predicting the prognosis of patients with bladder cancer.. Decision curve analysis (DCA) indicated that the clinical value of the nomogram was higher than the stage model and TNM model in predicting overall survival analysis. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.. The Creative Commons...
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Characteristics and clinical significance of CD163+/CD206+M2 mono-macrophage in the bladder cancer microenvironment. Bladder carcinoma is one of the most common urologic malignancies worldwide and is a heterogeneous disease (Siegel et al., 2018). In 2019, the American Cancer Society estimated 80,470 new cases of bladder cancer and 17,670 deaths due to bladder cancer in the United States (Siegel et al., 2019)....
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Classification of bladder cancer cell lines according to regulon activity. Classically, bladder cancer is diagnosed in two histopathological classes as ‘muscle invasive bladder cancer (MIBC)’ and ‘non-muscle invasive bladder cancer (NMIBC)’ with different prognostic and molecular characteristics (Jin et al., 2014). Hedegaard et al., 2016. Robertson et al., 2017. Tan et al., 2019). In this study, the authors, in addition,...
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verification of mechanism of miR-93-5p in bladder Cancer. Results: We identified that miR-93-5p, miR-516a-5p were simultaneously significantly increased both in UEs from BC compared with healthy control and BC tissue compared with normal tissue, which were verified by RT-qPCR in the validation cohort. Subsequently, the performance to discover BC of the miR-93-5p, miR-516a- 5p was further verified with an area...
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In this study, we aim to determine the clinical and immunological significance of metabolic subtypes according to the expression levels of genes related to glycolysis and cholesterol-synthesis in bladder cancer (BCa).. Results: The 4 metabolic subtypes exhibited distinct clinical, molecular, and genomic patterns. In addition, distinct immune cell infiltration patterns were observed across the 4 metabolic subtypes, with greater infiltration...
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Core promoter mutation contributes. to abnormal gene expression in bladder cancer. Core promoter con- trols transcriptional initiation. We hypothesized that mutation in core promoter abnormality could cause abnormal transcriptional initiation thereby the altered gene expression in bladder cancer.. Methods: In this study, we performed a genome-wide characterization of core promoter mutation in 77 Spanish bladder cancer cases.. Results: We identified...