Tìm thấy 14+ kết quả cho từ khóa "Immune microenvironment"
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Tumor immune microenvironment of the two clusters of LUAD patients. Consider- ing the obvious differences of the OS in two clusters of LUAD patients, we speculated that tumor immune microenvironment might be an important contributor to the LUAD progress. Based on the ssGSEA, we evaluated the pro- portion difference of 28 immune cell types in the two clusters (Table S1).
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Although the advent of next-generation sequencing technologies has enabled characterization of the molecular characteristics of PAAD [7], comprehensive analyses of the tumour immune microenvironment (TIME) to im- prove our understanding of tumour heterogeneity and to explore novel biomarkers for early diagnosis, prognostica- tion, and targeted therapies have been insufficient [8]..
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Methods: We utilized RNA sequencing and clinical data of HNSCC patients from the TCGA database to study the correlation between VEGF signaling pathway and tumor immune microenvironment, on aspect of immune cell infiltration, immune-related gene expression profiling and immune-related biological pathways.. Results: We observed that VEGF signaling pathway is positively correlated with immune cell infiltration, immune- related gene expression profiles, and the prognosis of HNSCC patients.
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We also found that even though the immune microenvironment is influenced by both stromal and immune cells, no differ- ence existed in the pT, pM, and pN classifications, except for differences between stage II vs stage IV. This suggests that components in the tumor microenvironment possess different and refined functions..
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We evaluated the effects of high FR risk on BC immune microenvironment in three aspects. Second, we determined the corre- lations between FR risk score and the infiltration levels of six crucial cancer-related immune cells based on Spearman method. To speculate the roles of FR risk signature in predict- ing the efficacy of ICIs, we investigated the relationships between FR risk level and six pivotal immune check- points (PD-L1, CTLA4, BTLA, LAG3, HAVCR2 and TIGIT).
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Bioinformatics analysis to screen the key prognostic genes in tumor microenvironment of bladder Cancer.. Bioinformatic profiling of prognosis-related genes in the breast cancer immune microenvironment.. https://doi.org/10.18632/aging.102373..
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It is prompted that CD45+CD14+CD163+ mono-macrophage. subset is significantly increased in bladder cancer microenvironment, which is one of the characteristics of tumor immune microenvironment.. mono-macrophage subset in bladder cancer tissue Monocyte macrophages are mainly involved in immune regulation and neovascularization in the tumor microenvironment (Arnold et al., 2019). Tie-2, CD31 and VEGFR2 are associated with neovascularization (Loges et al., 2007. Xu et al., 2019).
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Neoepitopes derived from aberrant AS events are recognized by T lymphocytes to induce antitumor immune responses [51]. Thus, we ana- lyzed the association between the risk score system based on 6 AS events and the immune infiltration level in the immune microenvironment. Although not all 6 AS events had the same trend, both risk score and 4 in 6 sample events were associated with the immune infiltra- tion level.
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In general, the immune microenvironment of colon cancer is very complex and worthy of further exploration and research..
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The explanation is that the tumor immune microenvironment is stronger in early stage TNBC than in advanced-stage TNBC for PD-L1 patient populations. Among them, the I-SPY2 Trial showed that the addition of PD-1/PD-L1 inhibitors could improve EFS in patients with TNBC, but the IMpassion031 trial showed that EFS was not beneficial, possibly because of the short follow-up time .
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Clinical significance of the immune microenvironment in ovarian cancer patients
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Immune landscape of the risk signature.. Mutation landscape of the risk signature.. 9 Enriched gene sets in the Hallmark collection for high- and low-risk patients.
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In addition, CXCL5, IL4 may be involved in the regulation of the immune microenvironment in renal cell carcinoma [26].. 8 GSEA of the risk scores of immune genes. have unique topological characteristics and related KIRC expression patterns in the networks. In the study, a predictive nomogram was generated.
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The influence of the tumour microbiome on the immune microenvironment is a double-edged sword and worthy of further study in a variety of cancers. In cancers of other areas of the digestive tract, there is not enough evi- dence for the interaction between the efficacy of can- cer therapy and the locally resident microbiome..
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Background: Infiltrating immune and stromal cells are important components of the endometrial cancer (EC) microenvironment, which has a significant effect on the biological behavior of EC, suggesting that unique immune-related genes may be associated with the prognosis of EC. Immune-related pathways were mostly enriched in the low-risk group, which had higher levels of immune infiltration and immune status..
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A gene expression profile related to immune dampening in the tumor microenvironment is associated with poor prognosis in gastric adenocarcinoma. Gu L, Chen M, Guo D, Zhu H, Zhang W, Pan J, et al. PD-L1 and gastric cancer prognosis: a systematic review and meta-analysis
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Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma. Results: PDAC patients with a high density of TILs in the TME or PD-1-positive T cells in tertiary lymphoid aggregates (TLAs) demonstrated a significantly better prognosis than those with a low density of TILs or PD-1- negativity, respectively.
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The immune score and matrix score of the patients can help to deter- mine the degree of immune cell infiltration in the tumour microenvironment and the tumour purity.
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This study improves our under- standing of how IORT-induced changes in the tumour microenvironment alter the immune response and in- duce anti-cancer immune activity in patients with pan- creatic cancer.. Thirty patients diagnosed with pancreatic cancer at the Gangnam Severance Hospital from 2018 to 2019 underwent pancreatic resection (Supplementary Table S1, Supplementary Table S2). The cells that remained in the top chamber were gently scraped off using wet cot- ton swabs.
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and microenvironment of lung adenocarcinoma patients with or without TP53 mutation. Background: Differences in genetics and microenvironment of LUAD patients with or without TP53 mutation were analyzed to illustrate the role of TP53 mutation within the carcinogenesis of LUAD, which will provide new concepts for the treatment of LUAD..