Có 20+ tài liệu thuộc chủ đề "Breast Cancer"
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A novel mutation of KCNQ2 gene in a patient with self-limited non-familial neonatal epilepsy: a case report. Background: In several genetic epilepsies, the genotype-phenotype relationship is complex in which pathogenic variants in the same gene may causes different epilepsy phenotypes. As a typical example, pathogenic variants of KCNQ2 have been known to cause either self-limited familial (and non-familial) neonatal epilepsy...
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Breast cancer PAM50 signature: correlation and concordance between RNA-Seq and digital multiplexed gene expression. Background: Full RNA-Seq is a fundamental research tool for whole transcriptome analysis. We evaluated the transcript quantification agreement between RNA-Seq and a digital multiplexed gene expression platform, and the subtype call after running the PAM50 assay in a series of breast cancer patients classified as triple...
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Refinement of breast cancer molecular. Background: Accurate classification of breast cancer using gene expression profiles has contributed to a better understanding of the biological mechanisms behind the disease and has paved the way for better prognostication and treatment prediction.. We also identified differential expression of the miR-99a/let-7c/miR-125b miRNA cluster as a marker for separation of the Luminal A and B...
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mRNA-seq whole transcriptome profiling of fresh frozen versus archived fixed tissues. For two of the three protocols tested, poly(A) selection (mRNA-seq) and ribosomal-depletion, the total gene expression profiles of matched FF and FFPE pairs were highly correlated.. Notably, although expression levels of FFPE samples by mRNA-seq were mainly represented by the 3 ′ -end of the transcript, they yielded very...
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Predictors of breast cancer cell types and their prognostic power in breast cancer patients. We investigate if the “ cell type ” of a cancer cell can be predicted based on the expression profiles of a small set of transcripts.. Results: We outline a predictive analytics pipeline to accurately predict 6 breast cancer cell types using single cell gene expression...
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Four visits will be scheduled at diagnosis, after treatments, and 12 and 18 months after diagnosis. The same procedure will be followed for each visit. Each session will be composed of anthropometric data collection, a semi-structured interview, cognitive tests, postural control tests, neuromuscular fatigability tests and a cardiorespiratory fitness test. Clinical and biological data will be collected during medical follow-ups....
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Background: Correct preoperative estimation of the malignant extent is crucial for optimal planning of breast cancer surgery. CEM may be more cost- effective than MRI, and may provide better identification of the tumor extent, however, no randomized trials have been performed to date to investigate the added value of CEM.. The purpose of the present study is to evaluate the...
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TFEB, SIRT1, CARM1, Beclin-1 expression and PITX2 methylation in breast cancer chemoresistance: a retrospective study. Background: Breast cancer chemoresistance is attributed to a wide variety of mechanisms, including autophagy.. Objective: This study aims to evaluate the prognostic impact of TFEB and its pathway in breast cancer chemoresistance.. A group of breast cancer patients treated with chemotherapy, who relapsed within 12...
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POstmastectomy radioThErapy in Node- posiTive breast cancer with or without Internal mAmmary nodaL irradiation (POTENTIAL): a study protocol for a multicenter prospective phase III randomized controlled trial. Background: Various randomized trials have demonstrated that postmastectomy radiotherapy (RT) to the chest wall and comprehensive regional nodal areas improves survival in patients with axillary node-positive breast cancer.. The results of this study...
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The relationship between dairy products intake and breast cancer incidence: a meta- analysis of observational studies. Background: The effect of dairy products intake on breast cancer (BC) is highly controversial. Table 2 Effects of dairy products on breast cancer incidence. ER+ breast cancer . ER- breast cancer . PR+ breast cancer . PR- breast cancer . ER+/PR+ breast cancer ....
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Clinical verification of body mass index and tumor immune response in patients with breast cancer receiving preoperative. patients with early-stage breast cancer who are obese (OB) per BMI measurements have been shown to have high postoperative recurrence and low survival rates. Therefore, we hypothesized that OB patients with breast cancer have a lower density of tumor-infiltrating lymphocytes (TILs), which may...
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In epithelial ovarian cancer (EOC), approximately 50% of cases involve HRD due to alterations of HRR pathway genes [21]. These breast and ovarian cancer cluster regions are shown below in Table 1. Individuals with this mutation are more prone to develop ovarian cancer than breast cancer. This mutation is associated with higher risk of ovarian cancer [39, 60]. An EMSY...
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Hotspot mutation profiles of AKT1 in Asian women with breast and endometrial. The clinicopathological features and frequencies in Asian populations with AKT1 mutations in breast and endometrial cancers are unclear. Hence, we aimed to determine the frequencies and relationships between clinicopathological features and AKT1 mutations in Asian women with cancer.. Methods: We extracted DNA from 311 and 143 samples derived...
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Combined analysis of PTEN, HER2, and hormone receptors status: remodeling breast cancer risk profiling. Background: Phosphatase and tensin homolog (PTEN) loss is associated with tumorigenesis, tumor progression, and therapy resistance in breast cancer. We sought to determine whether the benefit of traditional biomarkers testing is improved by the analysis of PTEN status for the identification of high-risk breast cancer.. Methods:...
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A comprehensive approach to risk factors for upper arm morbidities following breast cancer treatment: a prospective study. Background: Breast cancer surgery frequently causes deficiencies in shoulder functioning. Breast cancer (BC) surgeries and treatments can cause arm morbidity that can progress beyond 2.5 years [1].. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.. 1 Arm morbidity six-month postoperative after breast...
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Materials and methods: Using TCGA database, a novel FR risk signature was constructed through the Lasso regression analysis. Four validation cohorts ( n = 2248), including METABRIC, GSE58812, GSE20685 and ICGC-KR datasets, were employed to test the prognostic value of FR risk signature. The effects of FR risk signature on BC immune microenvironment were explored by CIBERSORT algorithm and ssGSEA...
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Ado-trastuzumab for the treatment of metastatic HER2-positive breast cancer in patients previously treated with. Background: Docetaxel in combination with two HER2-directed therapies, trastuzumab and pertuzumab, is the current standard frontline therapy for patients with metastatic HER2-positive breast cancer. However, the benefit of T-DM1 in patients previously treated with pertuzumab therapy for metastatic breast cancer remains unclear.. Methods: We identified thirty-three...
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Thus, we performed this monocentric retrospective study on five cases treated with SBRT for IMMs, which we supplemented with a systematic review of the literature.. These le- sions can appear at any time in the history of the onco- logical disease and can affect the medulla. Because of the low number of lesions treated, therapeutic standards are not clearly defined....
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MiR-16-5p suppresses breast cancer proliferation by targeting ANLN. This study aimed to explore the role of miR-16-5p and ANLN in breast cancer (BC).. A dual-luciferase reporter assay was used to prove the regulatory relationship of miR-16- 5p and ANLN. Moreover, ANLN was highly expressed, while miR-16-5p was lower in BC cells than in breast epithelial cells. Then, we confirmed that...
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Demographic, tumour, and treatment characteristics of female patients with breast cancer in Sri Lanka. Background: Although breast cancer is the most common cancer among Sri Lankan women, there is little published data on patient characteristics and treatment in the local context. We aimed to describe disease characteristics and management in a large contemporary cohort of women with breast cancer at...