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Triple negative breast cancer

Tìm thấy 13+ kết quả cho từ khóa "Triple negative breast cancer"

Breast cancer PAM50 signature: Correlation and concordance between RNA-Seq and digital multiplexed gene expression technologies in a triple negative breast cancer series

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The goal of the study was assessing the reproducibility of PAM50 intrinsic subtype when using RNA-Seq and Nano- String nCounter® data from FFPE tissue obtained from a triple negative breast cancer (TNBC) patient cohort.

Coordinated regulation of WNT/β-catenin, c-Met, and integrin signalling pathways by miR-193b controls triple negative breast cancer metastatic traits

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Coordinated regulation of WNT/ β -catenin, c-Met, and integrin signalling pathways by miR-193b controls triple negative breast cancer metastatic traits. Quantifying cell growth of three TNBC cell lines upon miRNA gain-of-function experiments, we characterised miR-193b as a strong and consistent repressor of proliferation. Importantly, the effects of miR-193b were stronger than chemical inhibition of the individual pathways.

Highly heterogeneous-related genes of triple-negative breast cancer: Potential diagnostic and prognostic biomarkers

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Triple-negative breast cancer: current state of the art. https://doi.org . https://doi.org/10.1093/abbs/gmaa072.. Targeting different pathways using novel combination therapy in triple negative breast Cancer.. Biology and Management of Patients with Triple-Negative Breast Cancer. https://doi.org/10.1634/. https://doi.org/10.1038/s . The fate of chemoresistance in triple negative breast cancer (TNBC). https://doi.org/10.1016/j.bbacli . Genetic markers in triple-negative breast Cancer.

A panel of miRNAs as prognostic markers for African-American patients with triple negative breast cancer

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MicroRNAs in regulation of triple-negative breast cancer progression. https://doi.org/10.1007/s . Breast Cancer Res Treat. https://doi.org/10.1016/bs.acr . Breast Cancer Res. Race disparities in the contribution of miRNA isoforms and tRNA-derived fragments to triple-negative breast cancer. https://doi.org CAN-17-1947.. https://doi..

Long non-coding RNA BRE-AS1 inhibits the proliferation, migration, and invasion of cancer cells in triple-negative breast cancer and predicts patients’ survival by downregulating miR-21

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The role of miR-21 in cancer. Diagnostic and prognostic value of circulating miR-21 for cancer: a systematic review and meta-analysis. The passenger strand, miR-21-3p, plays a role in mediating cisplatin resistance in ovarian cancer cells. High expression of miR-21 in triple-negative breast cancers was correlated with a poor prognosis and promoted tumor cell in vitro proliferation. Mechanism of serum miR-21 in the pathogenesis of familial and triple negative breast cancer.

Local treatment for triple-negative breast cancer patients undergoing chemotherapy: Breast-conserving surgery or total mastectomy?

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A review of triple-negative breast cancer. https://doi.org . Clinical management of breast cancer heterogeneity. https://doi.. Refinement of triple-negative breast Cancer molecular subtypes:. Triple-negative breast cancer: epidemiological considerations and recommendations. Caspase14 expression is associated with triple negative phenotypes and cancer stem cell marker expression in breast cancer patients.

Immune checkpoint inhibitors plus neoadjuvant chemotherapy in early triplenegative breast cancer: A systematic review and meta-analysis

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Triple-negative breast cancer molecular subtyping and treatment progress. Breast Cancer Res. Triple-negative breast Cancer:. Neoad- juvant therapy in early breast Cancer: treatment considerations and com- mon debates in practice. Triple-negative breast cancer: recent treatment advances. Immunotherapy for triple-negative breast cancer: existing challenges and exciting prospects. Blocking c-met and EGFR reverses acquired resistance of PARP inhibitors in triple-negative breast cancer..

DNA methylation profiles capturing breast cancer heterogeneity

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TN ’ and ‘ non-TN ’ are triple negative and non-triple negative breast cancers, respectively. ‘F1_TN’ and ‘F1_nonTN’. 4 Performance validation of pCpGs and pDMGs using the validation datasets. Heatmaps showing breast cancer subtypes classified using (a) pCpGs of GSE72245 on gene methylation, pDMGs of TCGA on (b) gene methylation and (c) gene expression.

Precision treatment exploration of breast cancer based on heterogeneity analysis of lncRNAs at the single-cell level

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Presenting Features of Breast Cancer Differ by Molecular Subtype. Breast cancer: basics, screening, diagnostics and treatment.. Triple negative breast cancer: looking for the missing link between biology and treatments. https://doi.org/10.18632/. Breast Cancer Res. https://doi.org/10.1186/bcr1666.. Triple-negative breast cancer histoclinical and molecular features, therapeutic management and perspectives.

Effect of Propofol on breast Cancer cell, the immune system, and patient outcome

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To understand the biology of breast cancer, breast cancer cell lines have been established and widely used to investigate the effect of drugs on cancer cell proliferation, apoptosis, migration and invasion. To date, more than 51 breast cancer cell lines have been separated from primary tumor, and successfully cultured in vitro [12]. MDA-MB-468 and MDA-MB-231 both belong to triple negative breast cancer cell lines.

Neo-CheckRay: Radiation therapy and adenosine pathway blockade to increase benefit of immuno-chemotherapy in early stage luminal B breast cancer, a randomized phase II trial

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RAdiation Therapy in Triple Negative Breast Cancer

Short-term serial assessment of electronic patient-reported outcome for depression and anxiety in breast Cancer

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Changes in the degree of depression and anx- iety were defined as either “improved” or “worsened.”. breast cancer. Triple negative breast cancer 17 (12.41). Table 1 Clinicopathological characteristics of patients with breast cancer (Continued). In addition, each questionnaire items were analyzed and compared, and the changes in the degree of depression and anxiety were analyzed..

A high CD8 to FOXP3 ratio in the tumor stroma and expression of PTEN in tumor cells are associated with improved survival in non-metastatic triple-negative breast carcinoma

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Overall Sur- vival of triple-negative breast cancer patients in the METABRIC cohort ac- cording to the expression of FOXP3 . Overall Survival of triple-negative breast cancer patients in the METABRIC cohort according to the ratio between the expression of CD4 to FOXP3 . Macedo analyzed the expression of PD-L1. https://doi.org . doi.org . https://doi.org/10.1007/s . Targeting immune co-stimulatory effects of PD-L1 and PD-L2 might represent an effective therapeutic strategy in stroke.

Transcriptional splice variants of CD40 and its prognostic value in breast cancer

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Here, we analyzed both CD40/CD40 ligand expression in breast cancer cells and tissues using public data sets and overall survival analysis in ungrouped breast cancer patients, as well as in the triple-negative breast cancer subtype. We detected CD40 gene expression along with its 3 different splice variants (variants 1–3), predominantly in the triple-negative subgroup of breast cancer cell lines.

Neoadjuvant everolimus plus letrozole versus fluorouracil, epirubicin and cyclophosphamide for ER-positive, HER2- negative breast cancer: A randomized pilot trial

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A phase Ib trial reported that first-line AKT inhibitor Ipa- tasertib in combination with atezolizumab and paclitaxel or nab-Paclitaxel in patients with advanced triple- negative breast cancer achieved a high ORR of 73% [31]..

Association of body composition with odds of breast cancer by molecular subtype: Analysis of the Mechanisms for Established and Novel Risk Factors for Breast Cancer in Nigerian Women (MEND) study

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Characterization of Nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular features. https://doi.org/10.1038/s . Population differences in breast cancer: survey in indigenous African women reveals over-representation of triple-negative breast cancer. https://doi.org/10.1200/JCO . Panoptic overview of triple- negative breast cancer in Nigeria: current challenges and promising global initiatives. https://doi.org/10.1200/JGO.17.00116..

Clinical verification of body mass index and tumor immune response in patients with breast cancer receiving preoperative chemotherapy

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All patients were patho- logically diagnosed with breast cancer by core needle biopsy or vacuum-assisted biopsy. Hormone receptor-positive breast cancer (HRBC) was defined as a tumor positive for ER and/or PgR. HER2-enriched breast cancer (HER2BC) was de- fined as ER-negative, PgR-negative, and HER2-positive.. Finally, triple-negative breast cancer (TNBC) was de- fined as ER-, PgR-, and HER2-negative.

Predictors of breast cancer cell types and their prognostic power in breast cancer patients

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The scRNASeq breast cancer data had 401 cells and originated from 6 different cell types populations: 15% estrogen receptor positive (ER. 29% triple-negative breast cancer (TNBC), and 8% BC07LN (lymph node metastasized triple-negative).. The second part of the analysis involves tuning various pre- dictive models for accurate prediction of cell type of breast cancer cells.. These steps reduced the number of genes in breast cancer data set to 5592 genes.

Clinicopathological characteristics and survival outcomes in patients with synchronous lung metastases upon initial metastatic breast cancer diagnosis in Han population

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TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-nega- tive breast cancer lung metastasis. Cancer-associated MORC2-mutant M276I regulates an hnRNPM-mediated CD44 splicing switch to promote invasion and metastasis in triple-negative breast Cancer.. Integration of whole- genome sequencing and functional screening identifies a prognostic signature for lung metastasis in triple-negative breast cancer.

Chapter 086. Breast Cancer (Part 13)

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Citron ML et al: Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: First report of intergroup trial C9741/cancer and leukemia group B trial 9741. Cleator S et al: Triple-negative breast cancer: Therapeutic options.