Tìm thấy 20+ kết quả cho từ khóa "Estrogen receptor"
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Từ khóa: Gen estrogen receptor, gen prolactin receptor, năng suất sinh sản, lợn Landrace, Yorkshire.. khác đã được công bố cho thấy các alen này có mối liên hệ với SCSS và SCSSS và cho rằng đây là một gen chính có ảnh hưởng tới một số chỉ tiêu sinh sản có thể dùng để chọn lọc (Rothschild và ctv (1994), Kmiéc và Vrtková (2002), Hunyadi-Bagi (2016)..
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Efficacy of adjuvant chemotherapy stratified by age and the 21-gene. recurrence score in estrogen receptor- positive breast cancer. Background: The 21-gene recurrence score (RS) can predict chemotherapy benefit in estrogen receptor-positive, human epidermal growth factor receptor-2-negative (ER+/HER2-) early breast cancer patients. Methods: Patients diagnosed with pN0 – 1, ER+/HER2- breast cancer between 2009 and 2016 were retrospectively reviewed.
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Cơ chế tác động của estrogen. Tác động của estrogen được xác. định bởi các yếu tố cấu trúc phân tử estrogen, cấu hình receptor, đặc. tính của các promoter cho các gene đích, sự cân bằng giữa các yếu tốc kích thích hay yếu tố hợp đồng. Kết hợp estrogen-estrogen receptor. Estrogen receptor kết hợp lỏng lẻo với protein liên kết receptor nằm trong tế bào chất.
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Estrogen cũng có thể được gắn thêm các nhóm. 2- và 4-hydroxyestrogens có thể được methyl hóa bởi catechol O-. estrogen kết hợp với các estrogen receptor và thể hiện hoạt tính yếu của estrogen ở động vật và có thể ức chế catechol O-. Thêm vào đó, catechol estrogen có thể tiếp tục tham gia. Các gốc tự do sinh ra trong quá trình biến đổi các. Dạng ester của estrogen có thể được tổng hợp tại các mô khác nhau (đặc biệt là mô mỡ), trong máu.
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GPR30 estrogen receptor agonists induce mechanical hyperalgesia in the rat. Estrogen action via the G protein- coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP- mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis. Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption.
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The role of estrogen and progesterone receptors in the rotator cuff disease:. The disease affects primarily women and occurs mainly in the postmenopausal period.. estrogen receptor-beta (ER-β) and progesterone receptor (PR) in the supraspinatus tendon of patients with RC tendinopathy, searching for gender differences of expression. A secondary aim was to evaluate potential links between their expres- sion and the typical histopathological findings of the ailment..
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In conclusion, our integrated analysis of RNA-Seq data and ChIP-Seq data identified estrogen receptor func- tional sites in the chicken genome and all of the genes, including protein-coding genes, miRNAs and lncRNAs, regulated via estrogen in the liver of chicken (Fig. These results increase our understanding of the functional net- work regulated by estrogen in liver of chicken and pro- vide insight into estrogen mediated lipid metabolism..
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Hormone receptor. 5 PFS subgroup analysis in patients with or without liver metastasis. Kaplan–Meier curves of PFS in patients who had liver metastasis or not. Primary and secondary prevention of breast cancer. breast cancer - a novel category? Romanian J Morphol Embryol. metastatic breast cancer con- fer resistance to estrogen receptor-directed therapies. Overcoming therapeutic resist- ance of triple positive breast Cancer with CDK4/6 inhibition. Int J Breast Cancer.
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We reported previously that estrogen promotes the growth of estrogen receptor α -negative mammary tumours in mice undergoing mammary involution through stimulating pro-tumoral activities of neutrophils in the mammary tissue.. Results: Estrogen treatment for 2-weeks reduces the number of blood LDN by more than 10-fold in tumour- bearing nulliparous and involuting mice, whilst it had no significant effect on blood HDN.
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Emergence of constitutively active estrogen receptor-α mutations in pretreated advanced estrogen receptor-positive breast cancer. The role of the AR/ER ratio in ER-positive breast cancer patients. Androgen receptor in advanced breast cancer: is it useful to predict the efficacy of anti-estrogen therapy? BMC Cancer
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Anastrozole is superior to tamoxifen in the adjuvant treatment of breast cancer in postmenopausal patients with estrogen receptor–positive tumors.. Adverse effects of aromatase inhibitors may include an increased risk of osteoporosis.
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Menstrual cycle could affect Ki67 expression in estrogen receptor-positive breast cancer patients. https://doi.org/10.1007/BF01806677.. menstrual cycle in oestrogen receptor-positive primary breast cancer. https://doi.org/10.1007/s . Menstrual cycle associated changes in hormone-related gene expression in oestrogen receptor positive breast cancer. NPJ Breast Cancer. https://doi.org/10.1038/s .
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The best means of ascertaining whether a breast cancer is hormone-dependent is through analysis of estrogen and progesterone receptor levels on the tumor. Tumors that are positive for the estrogen receptor and negative for the progesterone receptor have a response rate of ~30%. Receptor analyses provide information as to the correct ordering of endocrine therapies as opposed to chemotherapy.
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/i estrogen 2"m t4ng s9 phát triển c:a ung thư. b"o ung thư '8 estrogen receptor 'ư(c g
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The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults. Lack of association between estrogen receptor genotypes and bone mineral density fracture history, or muscle strength in elderly women.
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Background: The ESR1 gene encodes Estrogen Receptor alpha (ERα), which plays a role in the tumourigenesis of breast cancer. A single nucleotide polymorphism (SNP) in intron 1 of this gene called ESR1 PvuII (rs2234693) has been reported to increase the risk of breast cancer. This study aimed to investigate the ESR1 PvuII polymorphism as a prog- nostic and predictive factor guiding the choice of therapy for advanced breast cancer..
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Selective estrogen receptor modulators (SERMs) have been developed with the hope of a more beneficial modulation of ER activity, i.e., antiestrogenic activity in the breast, uterus, and ovary, but estrogenic for bone, brain, and cardiovascular tissues. Aromatase inhibitors, which block the. conversion of androgens to estrogens in breast and subcutaneous fat tissues, have demonstrated.
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Sevoflurane increases breast cancer cell survival at clinically relevant concentrations and durations in both estrogen receptor-positive and negative breast can- cer cells in vitro while propofol has no such effect.
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Significant P-values are emboldened LVI Lymphovascular Invasion, E Epithelial Component, ER Estrogen Receptor, PR Progesterone Receptor, CD3 Cluster of Differentiation 3, CD4 Cluster of Differentiation 4, CD8 Cluster of Differentiation 8, FOXP3 Forkhead Box P3, PD-1 Programmed Cell Death Protein 1, PD-L1 Programmed Death-Ligand 1, PD-L2 Programmed Death-Ligand 2 Clinicopathological featuresTotal no.
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On the other hand, many chemicals present in the aquatic environment have a feminizing effect since they are able to disrupt the endocrine system by mimicking the effects of estrogens through binding to the estrogen receptor [18]. Conse- quently, even at low environmental concentrations, a sufficiently long exposure can lead to the feminization of the entire population [19].. However, most of the studies referred to above were conducted in species with a strong sexual determining system (XX/.