Có 40+ tài liệu thuộc chủ đề "Overall survival"
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Adjuvant chemotherapy is an additional option for locally advanced gastric cancer after radical gastrectomy with D2. Background: This study compared the long-term efficacy of different durations of adjuvant chemotherapy for patients with gastric cancer after radical gastrectomy with D2 lymphadenectomy.. Methods: We retrospectively identified 428 patients with stage II – III gastric cancer who underwent D2 gastrectomy between 2009 and...
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Demographic and prognostic factors of optic nerve astrocytoma: a retrospective study of surveillance, epidemiology, and end results (SEER). Background: Optic nerve astrocytomas (ONAs) are neurological neoplasms in the central nervous system (CNS), and they have the highest incidence rate among all the tumor types in the visual pathway. Results: A total of 1004 cases were analyzed, and revealed that age...
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Construction of a survival prediction model for high-and low -grade UTUC after tumor resection based on “ SEER database. Background: There are differences in survival between high-and low-grade Upper Tract Urothelial Carcinoma (UTUC). Our study aimed to develop a nomogram to predict overall survival (OS) of patients with high- and low- grade UTUC after tumor resection, and to explore the...
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strategy to treat small cell carcinoma of the cervix: a comparative analysis of treatments. Background: Standard treatments for small cell carcinoma of the cervix (SCCC) have not been established. The median age of the included patients was 47 (range: 24 – 83) years. Of 53 patients who had undergone chemotherapy, 35 and 18 received SCCC and non-SCCC regimens as their...
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Herein, we aimed to explore the expression pattern and clinical implications of BATF2 in breast cancer (BC).. Methods: We assessed the differences in BATF2 mRNA expression between cancerous and noncancerous tissues in BC using GEPIA and UALCAN data and in BATF2 protein expression pattern using Human Protein Atlas (HPA) data.. The association between the differentially expressed BATF2 mRNA and BC...
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Contemporary treatment patterns and survival of cervical cancer patients in Ethiopia. Background: Cervical cancer is the second commonly diagnosed cancer and the second leading cause of cancer death in women in Ethiopia, with rates among the highest worldwide. However, there are limited data on cervical cancer treatment patterns and survival in the country. Herein, we examine treatment patterns and survival...
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Therapeutic method for early-stage second primary non-small lung cancer: analysis of a population-based database. Background: Early-stage non-small lung cancer patients may survive long enough to develop second primary lung cancers. However, few studies have accurately described the therapeutic method, evaluation or prognostic factors for long-term survival in this complex clinical scenario.. Methods: Patients who had first and second primary non-small...
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ipilimumab and non-ipilimumab therapies in advanced melanoma: the IMAGE study. Background: Ipilimumab has shown long-term overall survival (OS) in patients with advanced melanoma in clinical trials, but robust real-world evidence is lacking. Methods: IMAGE was a multinational, prospective, observational study assessing adult patients with advanced melanoma treated with ipilimumab or non-ipilimumab systemic therapies between June 2012 and March 2015 with...
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RRM1 and ERCC1 as biomarkers in patients with locally advanced and metastatic. Even though some advances have been achieved in the management of patients with MPM, this malignancy continuous to impose a deleterious prognosis for affected patients (12 – 18 months as median survival, and 5 – 10% 5-year survival rate), accordingly, the recognition of biomarkers that allow us to...
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Network meta-analysis of eribulin versus other chemotherapies used as second- or later-line treatment in locally advanced or metastatic breast cancer. Halaven®) is a microtubule inhibitor approved in the United States for metastatic breast cancer patients with at least two prior chemotherapy regimens for metastatic breast cancer, and in the European Union in locally advanced breast cancer or metastatic breast cancer...
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hepatocellular carcinoma with portal vein tumour thrombosis and construction of a nomogram. Conclusions: SBRT is an effective treatment for patients with HCC with PVTT. The presented nomogram can be used to predict the survival of patients with HCC and PVTT, who underwent SBRT.. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.. Keywords: Hepatocellular carcinoma, Portal vein tumour thrombosis, Stereotactic...
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A gene signature of prognosis-related DE-FRGs was established by univariate Cox analysis and LASSO analysis in the training set. Then several bioinformatics analyses were used to verify the reliability and accuracy of the model in the validation set. The receiver operating characteristic curve displayed the favour predictive performance of the risk model. Finally, ssGSEA preliminarily indicated that the poor prognosis...
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Consistency indices and calibration plots were used to assess the accuracy of the nomograms in both the internal and external cohorts.. Results: The median follow-up periods for HCC patients treated with RFA were 27 and 29 months for OS and CSS, respectively. Marital status, age, race, histological grade of differentiation, tumor size, T stage, and serum alpha- fetoprotein levels at...
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Outcomes of renal cell carcinoma with associated venous tumor thrombus:. Background: The surgical management and outcomes of renal cell carcinoma (RCC) with venous tumor thrombus (VTT) have been reported in limited sample size, and there remain discrepancies over the factors that influence oncologic outcomes after radical nephrectomy with thrombectomy (RNTE). The aim of the study was to analyze the outcomes...
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Functions and clinical significance of KLRG1 in the development of lung. This work intended to investigate the predictive ability of KLRG1 on the efficacy of immune-checkpoint inhibitor in the treatment of lung. adenocarcinoma (LUAD), as well as contribute to the possible molecular mechanisms of KLRG1 on LUAD development.. Methods: Using data from the Gene Expression Omnibus, the Cancer Genome Atlas...
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Such has been the case in the Italian regions of Piedmont and Lombardy, where industrial production of materials laden with asbestos, mainly cements, has been responsible for the onset of a large epidemic. Moreover, concerning second line treatments, vinorelbine emerged as the most advantageous choice for female patients, whereas in the male subgroup no statistically significant difference resulted between gemcitabine...
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Molecular identification of an immunity- and Ferroptosis-related gene signature in non-small cell lung Cancer. However, the role of immunity- and ferroptosis-related gene signatures in non-small cell lung cancer (NSCLC) remain unclear.. Univariate and multivariate Cox regression analyses were performed to identify ferroptosis-related genes. Results: A signature composed of five ferroptosis-related genes was established to stratify patients into high- and low-risk...
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Role of autophagy-related protein in the prognosis of combined hepatocellular carcinoma and cholangiocarcinoma after surgical resection. Methods: We prospectively investigated how these proteins affect clinical prognosis in 40 patients who underwent hepatectomy for cHCC-CC from 2011 to 2019 at a Taiwanese hospital. Results: We noted that LC3 expression was significantly correlated with mild clinicopathological characteristics, including macrovascular invasion, lymph node...
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Impact of surgical margin width on long- term outcomes for intrahepatic. Background: The objective of this study was to investigate the survival outcomes of surgical margin width in intrahepatic cholangiocarcinoma (ICC).. PSM yielded 79 matched patients with similar baseline characteristics. Conclusions: Surgeons should strive to achieve a wide surgical margin for patients with AJCC I ICC to optimize the long-term...
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Nomogram predict relapse-free survival of patients with thymic epithelial tumors after surgery. Background: Hematological indicators and clinical characteristics play an important role in the evaluation of the progression and prognosis of thymic epithelial tumors. The prognostic predictive ability of the nomogram was evaluated using the consistency index (C-index), receiver operating characteristic (ROC) curve, and risk stratification. Decision curve analysis was...