Có 20+ tài liệu thuộc chủ đề "Pancreatic Cancer"
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High-throughput sequencing of circRNAs reveals novel insights into mechanisms of nigericin in pancreatic cancer. Results: In this study, a total of 183 common differentially expressed circRNAs were identified, and the reliability and validity of the sequencing data were verified by the PCR analysis. According to the parental genes of circRNAs, the GO analysis was performed to predict the most enriched...
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Nanoliposomal irinotecan plus fluorouracil and folinic acid as a second-line treatment option in patients with metastatic. LV) showed improved overall survival compared to fluorouracil alone for patients with metastatic pancreatic cancer who were previously treated with gemcitabine-based therapy. In this study, we assessed real-world experience of nal-IRI plus 5-FU/LV in patients with advanced pancreatic cancer after gemcitabine failure.. Methods: We...
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Sphere and adherent cell culture of pancreatic cancer cell lines. Eight pancreatic cancer cell lines (AsPC-1, BxPC-3, Capan-1, Capan-2, Cfpac-1, HPAC, MiaPaca-2, and Panc-1) were purchased from the American Type Cul- ture Collection (ATCC). pancreatic cancer cells were transfected with siRNAs by using RNAiMAX reagent (Invitrogen, Carlsbad, Califor- nia, US). Table 1 List of proteins associated with cancer stem cells...
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Prognostic value of immune factors in the tumor microenvironment of patients with pancreatic ductal adenocarcinoma. Results: PDAC patients with a high density of TILs in the TME or PD-1-positive T cells in tertiary lymphoid aggregates (TLAs) demonstrated a significantly better prognosis than those with a low density of TILs or PD-1- negativity, respectively. Moreover, PDAC patients with high levels of...
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Nomogram to predict survival of patients with advanced and metastatic pancreatic Cancer. Background: Nomograms are rarely employed to estimate the survival of patients with advanced and metastatic pancreatic cancer (PC). Herein, we developed a comprehensive approach to using a nomogram to predict survival probability in patients with advanced and metastatic PC.. Methods: A total of 323 patients with advanced and...
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ROR1 protein expression was not associated with stage, grade or OS in the APGI cohort.. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.. International Cancer Genome Consortium (ICGC, https://icgc.org/),the Cancer Genome Atlas...
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curative surgical resection in patients with hepatic Oligometastatic adenocarcinoma of the pancreas (HOLIPANC). Methods: In this single arm, phase-2 trial, survival data from patients receiving neoadjuvant chemotherapy followed by R0/R1 resection will be compared to historic data from patients with oligometastatic. adenocarcinoma of the pancreas.. 1 Department of General, Visceral, Tumor and Transplantation Surgery, University of Cologne, Kerpener Strasse 62,...
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Methods: We knocked down XRCC1 expression by using pLVX-shXRCC1 in the MiaPaCa2 cells and BxPC3 cells and evaluated β -lap-induced DNA lesions by γ H2AX foci formation and alkaline comet assay. To test our hypothesis, we examined the reactive oxygen species (ROS) level, DNA damage and cell death in β-lap-treated XRCC1-deficient MiaPaCa2 cells. MiaPaCa2, BxPC3, HS766T, S2 – 013 and...
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Background: Pancreatic cancer has highly aggressive features, such as local recurrence that leads to significantly high morbidity and mortality and recurrence after successful tumour resection. We investigated changes in the immune response induced by IORT by analysing the peritoneal fluid (PF) and blood of patients with and without IORT treatment after pancreatic cancer surgery. Results: Levels of cytokines involved in...
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These cells also displayed phenotypic changes in cellular migration consistent with activation of the EMT pathway. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.. Correspondence: [email protected]. 2 HudsonAlpha Institute for Biotechnology, Huntsville,...
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Murine in vivo studies were carried out to examine the effectiveness of the direct injection of PV-10 into syngeneic pancreatic tumors in causing lesion-specific ablation. Intralesional PV-10 treatment was combined with systemic gemcitabine treatment in tumor-bearing mice to investigate the control of growth among treated tumors and distal uninjected tumors. Results: In this study, we demonstrate that the injection of...
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comparison of modified FOLFIRINOX and gemcitabine plus nab-paclitaxel as first-line chemotherapy in advanced pancreatic. Background: Modified FOLFIRINOX and gemcitabine plus nab-paclitaxel (GEM-NAB) have been recommended as first-line therapies for advanced pancreatic cancer (PC). Due to the lack of evidence to directly compare them, we conducted this network meta-analysis to indirectly compare the effectiveness and toxicity of modified FOLFIRINOX and GEM-NAB.....
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Autoimmune pancreatitis – An ongoing challenge. Autoimmune pancreatitis Chronic pancreatitis IgG4-related disease Pancreatic insufficiency Pancreatic cancer. Autoimmune pancreatitis is a rare form of chronic pancreatitis. Clinically is autoimmune pancreatitis manifested by icterus and abdominal discomfort. Differential diagnosis between the focal form of autoimmune pancreatitis and pancreatic cancer can be complicated, with endosonography playing an important role. The relationship between autoimmune...
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for chemotherapy-induced peripheral neuropathy in pancreatic cancer patients. Background: The prognosis of pancreatic cancer (PC) has been improved by new chemotherapy regimens (combi- nation of 5-fluorouracil, oxaliplatin, irinotecan, and leucovorin (FOLFIRINOX) or gemcitabine plus nab-paclitaxel (GnP)).. Nota- bly, the rate of CIPN improvement was higher in the mirogabalin group than in the pregabalin group (2 weeks: 84.6%. Keywords: chemotherapy-induced peripheral...
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Pancreatic fibrosis, acinar atrophy and chronic inflammation in surgical specimens associated with survival. in patients with resectable pancreatic ductal adenocarcinoma. We, therefore, investigated the potential role of histological chronic pancreatitis findings and chronic inflammation on surgical PDAC specimens and disease-specific survival (DSS).. Results: DSS among patients with no fibrosis, acinar atrophy or chronic inflammation identified on pathology slides was significantly...
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Pancreatic Cancer. Pancreatic Cancer: Introduction. These tumors occur twice as frequently in the pancreatic head compared to the rest of the organ, and tend to be aggressive, often presenting when locally inoperable or after distal metastases have occurred. Patients with pancreatic cancer have a poor prognosis, with a 5-year survival of only 5%. The discussion of pancreatic cancer here will...
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Jaundice may be a presenting feature in some;. in these patients a palpable, nontender gallbladder (Courvoisier's sign) may be palpated under the right costal margin. The left supraclavicular lymph node (Virchow's node) may be involved with tumor, or widespread peritoneal disease may be palpable on rectal examination in the pouch of Douglas.. Endoscopic ultrasound (EUS) may be useful in the...
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Pancreatic Cancer. Carcinoma of the pancreas. Sonogram showing pancreatic carcinoma (P), dilated intrahepatic bile ducts (d), dilated portal vein (pv), and inferior vena cava (IVC). Computed tomography scan showing pancreatic carcinoma (dark arrows). Endoscopic retrograde showing abrupt c utoff of the duct of Wirsung (arrow). Patients with disease that is potentially curable by surgery, and in whom a highly suspicious...
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Pancreatic Cancer. Pancreatic Cancer: Treatment. Symptoms and the associated impaired performance status are significant issues in the management of patients with pancreatic cancer, as they can have a marked negative impact on the ability to safely deliver chemotherapy or perform curative surgery. For example, patients with malabsorption secondary to pancreatic insufficiency may be treated with pancreatic enzyme supplementation.. Advanced Pancreatic...
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Pancreatic Cancer. from the European Study Group for Pancreatic Cancer 1 (ESPAC1) trial for the comparison of adjuvant chemotherapy versus no adjuvant chemotherapy (CT) in patients with resected pancreatic cancer (hazard ratio for death, 0.71. (Reprinted with permission from JP Neoptolemos, DD Stocken, H Friess, et al: A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. Alexakis...