Tìm thấy 14+ kết quả cho từ khóa "Cancer stem cell"
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Table 1 List of proteins associated with cancer stem cells that were upregulated in spheres compared to adherent cells of pancreatic cancer cell lines. 1 Validation GLRX3 expression in pancreatic cancer cell lines: A-B GLRX3 expression in pancreatic cancer cell lines. A GLRX3 mRNA was expressed in various pancreatic cancer cell lines. B GLRX3 protein was expressed in various pancreatic cancer cell lines.
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Stichoposide D impacts on cell-cycle of NTERA-2 cancer stem cell. (B) stichoposide D at 0,5 µM. (C) stichoposide D at 1 µM after 24 hours incubation. Stichoposide D affects surface markers on cancer stem cells. CD44 and CD24 alone or in combination have been reported as markers to distinguish cancer stem cells from cancer cell population (Jaggupilli and Elkord, 2012). CD44 + /CD24 + expression were different among tumor cell lines. but highly in breast CSCs (Ricardo et al., 2011)..
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A more sophisticated understanding of the stem-cell organization of cancers may lead to improved strategies for attacking the many common and difficult-to-treat types of malignancies that have been relatively refractory to interventions aimed at dividing cells.. Does the concept of cancer stem cells provide insight into the cellular origin of cancer? The fact that some cells within a cancer have stem cell–like properties does not necessarily mean that the cancer arose in the stem cell itself..
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Previous studies demonstrated that these genes are essential for the regulator of cell proliferation and maintenance of CSCs (Ben-Porath et al., 2008. As reported above, SOX2 and OCT4 are stem cell predictor factors that induce the expression of each other, regulate cancer progression, and are biomarkers of CSCs (Ben-Porath et al., 2008). Aztopal N, Erkisa M, Erturk E, Ulukaya E, Tokullugil AH et al.. Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW et al.
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In order to characterize the effects of CRBP-1 to the self-renewal ability of CSCs, CRBP-1 overexpressed PLC/PRF/5 and Huh7 cells were cultured in cancer stem cell culture medium for growing tumor sphere. inhibited by overexpression of CRBP-1 (Fig. In order to identify the role of CRBP-1 in cancer cell chemotherapy resistance, the first-line treatment drug for advanced HCC—sorafenib was used to treat CRBP-1 overexpressed PLC/PRF/5 cells.
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The cancer stem cell pool is expanded, and rapidly proliferating progeny, through additional mutations, may attain stem cell properties, although most of this population is thought to have a limited proliferative capacity. The cancer stem cell hypothesis has led to the idea that current cancer therapies may be effective at killing the bulk of tumor cells, but do not kill tumor stem cells, leading to a regrowth of tumors that is manifested as tumor recurrence or disease progression..
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The aims of this study is to isolate potential candidate breast cancer stem cell from the MCF-7 cell line to find out whether it is possible to isolate cancer stem cells using two cell surface markers: CD44 and CD24. Stem-like properties were studied in vivo by observing the tumorigenicity of different cell populations in immunosuppressed mouse models.
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Calvet CY, André FM, Mir LM (2014) The culture of cancer cell lines as tumorspheres does not systematically result in cancer stem cell enrichment. Chen J, Liu Q, Xiao J, Du J (2015) EpCAM-Antibody- Labeled Noncytotoxic Polymer Vesicles for Cancer Stem Cells-Targeted Delivery of Anticancer Drug and siRNA.. Clevers H (2011) The cancer stem cell: premises, promises and challenges. Gil J, Stembalska A, Pesz KA, Sasiadek MM (2008) Cancer stem cells: thetheoryandperspectivesin cancer therapy..
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We categorised cell lines into human cell lines, murine cell lines, and cancer stem cell-like patient-derived cell lines.. Patient-derived cell lines were developed from patients with malignant glioma at the investigators’ institute. Cell viability was our outcome of interest.
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Importantly, we found that TDO2 expression was associated with PD-L1 expression, T cell exhaustion markers, and enhanced proliferation and invasive activities of RCC cells. We have already re- ported that TDO2 expression correlated with cancer stem cells in esophageal cancer [12]. Al- though TDO2 expression did not correlate with other cancer stem cell markers such as ALDH1 or CD133, our data encourage future study to fully determine the role of TDO2 in RCC stem cells..
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CISD1 promotes human breast cancer proliferation and confers autophagy resistance [19, 20]. CS restrains ag- gressive triple-negative breast cancer cells by targeting glycolysis and the cancer stem cell phenotype [21].
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In particular, impaired autophagic flux is associated with chronic inflammation, immunosuppression, matrix formation, cancer stem cell generation, angiogenesis, metastasis, and metabolic reprogramming in the tumour microenvironment. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material.
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Rapamycin inhibits FBXW7 loss-induced epithelial-mesenchymal transition and cancer stem cell-like characteristics in colorectal cancer cells. https://doi.org/10.1016/j.bbrc . Yang H, Lu X, Liu Z, Chen L, Xu Y, Wang Y, et al. https://doi.org/10.18632/oncotarget.3355.. Wang Y, Zhang P, Wang Y, Zhan P, Liu C, Mao J-H, et al. https://doi.org CAN-16-2246.. Kemp Z, Rowan A, Chambers W, Wortham N, Halford S, Sieber O, et al.. https://doi.org CAN-05-2565..
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Besides, as compared to normal stem cells,miRNAs have diverse expression profiles in breast cancer stem cells, especially miR-200b-200a, miR-200c-141 also miR have significantly lessened expression levels (Jafari et al., 2018)..
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Conclusions: Prostate cancer cells appear to retain their responsiveness to stromal PENK signaling. Loss of prostate cancer differentiation is like reprogram- ming from luminal-like to stem-like.. Keywords: Prostate cancer differentiation, Stromal factor PENK, Stem cell factors, Luminal-like adenocarcinoma, Stem-like small cell carcinoma, Differentiation marker AGR2.
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Lanza R et al (eds): Essentials of Stem Cell Biology. Mimeault M et al: Stem cells: A revolution in therapeutics-recent advances in stem cell biology and their therapeutic applications in regenerative medicine and cancer therapies. National Institutes of Health: Stem cell information page. Puceat M, Ballis A: Embryonic stem cells: From bench to bedside. Sugarman J: Ethics and stem cell therapeutics for cardiovascular disease.. Vats A et al: Stem cells
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Stem Cell Biology (Part 3). In mice, it has been demonstrated that ES cells derived from. blastocysts made by somatic cell NT are indistinguishable from normal ES cells.. NT can potentially be used to produce patient-specific ES cells carrying a genome identical to that of the patient. Alternatively, successful nuclear reprogramming of somatic cells by fusing them with ES cells has been demonstrated in mouse and human.. Stem Cell Plasticity or Transdifferentiation.
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Alternative splicing associated with cancer stemness in kidney renal clear cell. However, we found that existing methods do not perform well in assessing the stemness of KIRC patients, and they overlooked the impact of alternative splicing.
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Review control of the embryonic stem cell state.
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These isolated stem cells, e.g., hematopoietic stem (HS) cells, can be studied in detail and used in clinical applications, such as bone marrow transplantation (Chap. However, the lack of specific cell-surface markers for other types of stem cells has made it difficult to isolate them in large quantities.. Alternatively, putative stem cells have been isolated from a variety of tissues as side population (SP) cells using fluorescence-activated cell sorting after staining with Hoechst 33342 dye.