Tìm thấy 13+ kết quả cho từ khóa "Cancer stem cells"
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Stichoposide D stimulates caspase-3 activity in NTERA-2 cancer stem cells after 24 hours of treatment at various concentrations. *P<0.05. Stichoposide D impacts on cell-cycle of NTERA-2 cancer stem cell. (B) stichoposide D at 0,5 µM. (C) stichoposide D at 1 µM after 24 hours incubation. Stichoposide D affects surface markers on cancer stem cells.
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A more sophisticated understanding of the stem-cell organization of cancers may lead to improved strategies for attacking the many common and difficult-to-treat types of malignancies that have been relatively refractory to interventions aimed at dividing cells.. Does the concept of cancer stem cells provide insight into the cellular origin of cancer? The fact that some cells within a cancer have stem cell–like properties does not necessarily mean that the cancer arose in the stem cell itself..
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Identification of pancreatic cancer stem cells. https://doi.org/10.3748/wjg.14.3903.. c-Met is a marker of pancreatic cancer stem cells and therapeutic target. https://doi.org/10.2147/OTT.S100510.. https://doi.org/10.1016/j.. CD44-positive cells are responsible for gemcitabine resistance in pancreatic cancer cells. https://doi.org/10.1002/ijc.24573..
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Alternative splicing not only progresses during the differentiation of stem cells, but also changes during the acquisition of the stemness features of cancer stem cells. we constructed a KIRC-specific stemness prediction model using an algorithm called one-class logistic regression based on the expression and alternative splicing data to predict stemness indices of KIRC patients, and the model was externally validated.
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Calvet CY, André FM, Mir LM (2014) The culture of cancer cell lines as tumorspheres does not systematically result in cancer stem cell enrichment. Chen J, Liu Q, Xiao J, Du J (2015) EpCAM-Antibody- Labeled Noncytotoxic Polymer Vesicles for Cancer Stem Cells-Targeted Delivery of Anticancer Drug and siRNA.. Clevers H (2011) The cancer stem cell: premises, promises and challenges. Gil J, Stembalska A, Pesz KA, Sasiadek MM (2008) Cancer stem cells: thetheoryandperspectivesin cancer therapy..
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It is believed that cancer stem cells originated from normal stem cells, as they have a longer lifespan than differentiated cells. This allows normal stem cells to accumulate mutations, causes unregulated cell proliferation (Martínez-Climent et al., 2006).. Breast cancer is the fifth most common cause of cancer death worldwide and is the most common cancer in women.
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As reported above, SOX2 and OCT4 are stem cell predictor factors that induce the expression of each other, regulate cancer progression, and are biomarkers of CSCs (Ben-Porath et al., 2008). Aztopal N, Erkisa M, Erturk E, Ulukaya E, Tokullugil AH et al.. Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW et al. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA et al. Chen J, Ren Q, Cai Y, Lin T, Zuo W et al. Chen N, Chon HS, Xiong Y, Marchion DC, Judson PL et al.
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Some reports indicate that ABCG2 is expressed uniquely in cancer stem cells, a minority of the total cell population;. D Quantification of the scratch assays shows a significant difference with HDAC1 overexpression (Student ’ s T-test). In fact, some of the key genes involved in EMT (e.g. For that reason, a deeper un- derstanding of the downstream effectors of resistance following HDAC1 overexpression is critical to identi- fying alternative and hopefully more suitable thera- peutic targets..
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Oncogenic mutations may occur in bone stem cells (red) and can cause the transformation to a bone cancer stem cell, generating “poor-prognosis” tumors (orange). Under the influence of stromal fibroblasts, only the popula- tion of bone cancer stem cells has the ability to metastasize. There might be variant cancer stem cells that differ in their tissue selectivity for metastasis, expressing an additional tissue-specific profile (e.g., green liver, purple lung).
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Cells adapted to ER stress gain the MDR phenotype, boost PERK expression, and PERK-linked Nrf2/MRP1 signal axis (Wu et al., 2018). Therefore, it is worth noting that ER stress sensors can be MDR inducers (Salaroglio et al., 2017). Besides, as compared to normal stem cells,miRNAs have diverse expression profiles in breast cancer stem cells, especially miR-200b-200a, miR-200c-141 also miR have significantly lessened expression levels (Jafari et al., 2018)..
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Breast cancer stem cells and the challenges of eradication: a review of novel therapies. https://doi.org/10.21037/sci . https://doi.org/10.1136/. https://doi.org/10.1182/. https://doi.org/10.1097/MOH . https://doi.org/10.1136/esmoopen .
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Ropivacaine, lidocaine and bupivacaine are amide-linked local anesthetics and act on neuron cells via blocking voltage-gated sodium-channel (VGSC). In addition, local anesthetics preferentially target cancer stem cells [14]. Apart from their direct inhibitory effects on tumor cells, ropivacaine and lidocaine also negatively affect tumor microenvironment, such as angiogenesis [15, 16]..
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Several pathways have been proposed to be implicated in stem cell prolif- eration: TGFβ, Notch, Wnt and Hedgehog are some examples [19]. The detailed mechanisms directing transformation of stem cells to cancer stem cells and hepa- tocellular cancer, however, remain still to be elucidated and definitive markers for these putative cancer stem cells have not yet been established.. HCC is one of the most vascular solid cancers, associated with a high propen- sity for vascular invasion.
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Cancer Stem Cells. and negative for other differentiation markers) and resemble normal stem cells in many ways, but are no longer under homeostatic control (Fig. Solid tumors may also contain a population of stem cells. Cancer stem cells, like their normal counterparts, have unlimited proliferative capacity and paradoxically traverse the cell cycle at a very slow rate.
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Keywords: Extracellular vesicles, umbilical cord-derived mesenchymal stem cells, microRNAs.. Mesenchymal stem cells (MSCs) are pluripotent adult stem cells isolated from mature tissues and able to renew and. E-mail address: [email protected] https://doi.org vnunst.5302.
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Hematopoietic Stem Cells (Part 4). Stem cells are multipotent. SCF, stem cell factor. The hematopoietic stem cell must balance its three potential fates:. memory T and B cells and among stem cells. Self-renewal capacity gives way to differentiation as the only option after cell division when cells leave the stem cell compartment, until they have the opportunity to become memory lymphocytes.
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Hematopoietic Stem Cells (Part 3). Excess Capacity of Hematopoietic Stem Cells. In the absence of disease, one never runs out of hematopoietic stem cells.. Indeed, serial transplantation studies in mice suggest that sufficient stem cells are present to reconstitute several animals in succession, with each animal having normal blood cell production.
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Refining our knowledge of how stem cells get into and out of the bone marrow may improve our ability to obtain stem cells and make them more efficient at finding their way to the specific sites for blood cell production, the so-called stem cell niche.. Hematopoietic Stem Cell Microenvironment.
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Hematopoietic Stem Cells (Part 1). Hematopoietic Stem Cells. Hematopoietic Stem Cells: Introduction. poiesis: creation) stem cells. If the hematopoietic stem cell is damaged and can no longer function (e.g., due to the nuclear accident at Chernobyl), a person would survive 2–4 weeks in the absence of extraordinary support measures. Stem cells produce tens of billions of blood cells daily from a stem cell pool that is estimated to be only in the hundreds of thousands.
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INHIBITED GROWTH OF MESENCHYMAL STEM CELLS UNDER SIMULATED MICROGRAVITY. This study aimed to estimate the effects of simulated microgravity (SMG) on mesenchymal stem cells (MSCs). The 3D clinostat was applied to induce to simulated microgravity on MSC. The results showed that the MSC density in control group was higher than the SMG group.