Có 16+ tài liệu thuộc chủ đề "Drug resistance"
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Based on simulations, we showed that chunking also increases sensitivity of the predictions, reaching 100% with as few as 20 sequences in a small proteome as in the influenza case (5k sites), but may require at least 30 sequences to reach 90% on larger alignments (500k sites). While both algorithms performed well in the case of the influenza data, results...
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Results: Here, we present a genome-wide analysis of two genetic crosses between ivermectin resistant and sensitive isolates of the parasitic nematode Haemonchus contortus, an economically important gastrointestinal parasite of small ruminants and a model for anthelmintic research. 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0. 6 Department of Comparative...
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Genome-wide analysis of Mycobacterium tuberculosis polymorphisms reveals lineage- specific associations with drug resistance. There is a need for increased sensitivity of genome-wide approaches in order to elucidate the genetic basis of anti-microbial drug resistance and gain a more detailed understanding of Mtb genome evolution in a context of widespread antimicrobial therapy. Population structure within the Mtb complex, due to clonal...
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Altered expression of K13 disrupts DNA replication and repair in Plasmodium falciparum. Background: Plasmodium falciparum exhibits resistance to the artemisinin component of the frontline antimalarial treatment Artemisinin-based Combination Therapy in South East Asia. Single non-synonymous mutations in the propeller region of PF3D7_1343700. Results: A set of RNA-seq and microarray experiments confirmed that the expression profile of k13 is specifically altered...
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Chromosome aneuploidy was observed in both groups but was more frequent in CL-SL. Genes encoding amastins were present in higher copy numbers in VL-SL and CL-PR as well as being among predicted pseudogenes in CL-SL. Both chromosome and SNP profiles showed CL-SL and VL-SL to form two distinct groups. Full list of author information is available at the end of...
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associated with drug resistance. Background: Drug resistance in Mycobacterium tuberculosis (MTB) is one of the major challenges in tuberculosis (TB) treatment. However, known mutations cannot explain all of the cases of resistance and little research has focused on the relationship between insertions / deletions (indels) and drug resistance.. Results: Here, we retrieved whole genome sequencing data of 743 drug-resistant MTB...
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Single-virion sequencing of lamivudine- treated HBV populations reveal population evolution dynamics and demographic. Here we applied BAsE-Seq, an Illumina-based single-virion sequencing technology, to eight samples from four chronic hepatitis B (CHB) patients – once before antiviral treatment and once after viral rebound due to resistance.. Results: With single-virion sequencing, we obtained single-virion sequences per sample, which allowed us to find...
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Despite the genetic heterogeneity of the leukemias studied, transcriptional analysis found concerted changes in gene expression in resistant blasts. The refractory gene signature was highly enriched with targets of the transcription factor FOXM1. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless...
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Japanese patients with hormone receptor- positive advanced breast cancer. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.. Full list of author information is available at the end of the article. Women in whom ovarian function has been suppressed by irradiation of the ovaries or treatment with luteinizing hormone-releasing hormone agonists (goserelin acetate or leuprorelin acetate) were ineligible.. or ENT...
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The predictive efficacy of the signature for chemotherapy and immunotherapy was also tested. We found that the low-risk group presented with better survival (Kaplan-Meier analysis, p <. As for the practicality of this signature, the IC50 of cytotoxic chemotherapeutics was significantly higher in the high-risk group. The low-risk group also presented with higher immunophenoscore (IPS) in both the “ CTLA4+...
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These cells also displayed phenotypic changes in cellular migration consistent with activation of the EMT pathway. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.. Correspondence: [email protected]. 2 HudsonAlpha Institute for Biotechnology, Huntsville,...
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metabolism in colorectal cancer cell line, HT-29. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted...
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To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.. Scheuermann et al. Both 786–0 cells (obtained from the American Type Culture Collection (ATCC. 786–0 wild type (786–0 WT) cell line is VHL defective...
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Methods: Primary TKAs revised for the first time due to verified or suspected infection were collected nationwide in Sweden during 2018, and in Lithuania between 2011 and 2020 from a single major TKA revision centre in Kaunas. Results: The majority of the infected cases in Sweden were early-type prosthetic joint infection (PJI) (44. More polymicrobial infections were observed in Sweden...
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PROTEOMIC PROFILING OF MULTIDRUGSUSCEPTIBLE AND RESISTANT STRAINS OF Mycobacterium tuberculosis Truong Quoc Phong 1. The emergence of multidrugresistant tuberculosis has attracted a great deal of interest in understanding the mechanism of drug resistance in Mycobacterium tuberculosis and the development of new therapeutics, diagnostics and vaccines. The majority of identified proteins have predicted roles in lipid metabolism, intermediary metabolism, cell wall...
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STUDY ON PREVALANCE OF DRUG RESISTANCE AND GENETIC MUTATION FOR DRUG RESISTANCE HIV ON HIV/AIDS PATIENTS WITH FIRST-LINE ANTIRETROVIRAL. TREATMENT FAILURE AT DONGDA HOSPITAL HA NOI. Objectives: To study prevalence of drug resistance and genotype testing for drug resistance HIV on HIV/AIDS patients with first-line antiretroviral treatment failure at Dongda Hospital, Hanoi. Subjects and methods: Cross-sectional, descriptive, prospective study on...