Tìm thấy 16+ kết quả cho từ khóa "Liver metastasis"
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This retrospective study aimed to assess the implication of apoB‑to‑apoAI ratio in predicting liver metastasis from rectal cancer (RC).. Serum apoAI, apoB and apoB‑to‑apoAI ratio were analyzed for their correlation with the liver‑metasta‑. tures of the patients. Results: Carbohydrate antigen U/ml, apoB‑to‑apoAI ratio ≥ 0.63, tumor regression grade 5 − 3, pT4 and pN + stage emerged as independent predictors of poorer liver‑metastasis‑free survival.
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This study compared a group of 236 patients with stage IV WT (synchronous lung and/or Fig. liver metastasis) to a group of 244 patients with relapsed WT and metachronous lung and/or liver metastasis.. Patient characteristics The 14 included studies reported on 212 pediatric patients with WTLM. Among the 93 patients with LR, 60 had synchronous LM (65. In the subgroup of patients with syn- chronous LM, OS was 75%. In the subgroup of patients with metachronous LM, OS was 65%.
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And multivariate analysis showed that gender, race, age at diagnosis, Gleason grade, histology, T stage, N stage, bone metastasis, liver metastasis and marital status were independent risk factors for predicting overall early death in patients with LCBM.
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In contrast, significantly longer survival was achieved by patients with mNPC with synchronous liver metastasis having. ≥6 cycles of chemotherapy compared to those receiving. 6 cycles of chemotherapy [22]. It is worth noting that we also found that patients who received ≥6 cycles of chemotherapy also benefited in OS and PFS compared with those who received <. 6 cycles of chemotherapy.
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PFS in patients who received trastuzumab and fulvestrant com- bination therapy as ≤3rd line treatment or did not have liver metastasis tended to be better compared to those in patients who received the treatment in later line or with liver metastasis. Median PFS was 7.3 months (95% CI and median OS was not achieved in patients. receiving trastuzumab and fulvestrant combination ther- apy as ≤3rd line treatment.
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Presence of liver metastasis has been reported as an important predictor of survival in patients with various cancers [4, 22], and the MPACT trial showed that the presence of liver metastasis is an important predictor of survival also in patients with pancreatic cancer [4].. Liver metastasis is associated with activation of hepatic stellate cells, which are key components of the hepatic tumor microenvironment Fig. 1 Flow diagram showing the development of the prognostic nomogram..
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Response of liver metastases to preoperative radiochemotherapy in patients with locally advanced rectal cancer and resectable synchronous liver metastases. The role of adjuvant pelvic radiotherapy in rectal cancer with synchronous liver metastasis: a retrospective study. What to choose as radical local treatment for lung metastases from Colo-rectal cancer: surgery or radiofrequency ablation?.
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LncRNA SNHG7 sponges miR-216b to promote proliferation and liver metastasis of colorectal cancer through upregulating GALNT1. LncRNA SNHG7 promotes pancreatic cancer proliferation through ID4 by sponging miR-342-3p. LncRNA SNHG7 promotes cardiac remodeling by upregulating ROCK1 via sponging miR-34-5p. LncRNA SNHG7/miR-34a-5p/SYVN1 axis plays a vital role in proliferation, apoptosis and autophagy in osteoarthri- tis.
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Patients with liver metastasis had worse survival outcomes (mPFS: 3.1 months and mOS: 3.1 months) compared with patients without liver metastases, which agreed with previous studies.. A study demonstrated that the mPFS was only 2.3 months in EGFRm+ patients with liver metastases treated with erlotinib as second- or third-line treat- ment [22].
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Patients with high-risk tumors (high β-hCG levels, disease presenting ≥4 months after antecedent pregnancy, brain or liver metastasis, or failure of single- agent methotrexate) are initially treated with combination chemotherapy. EMA-CO is now the regimen of choice for patients with high-risk disease because of excellent survival rates (>80%) and less toxicity. As a result, etoposide-containing regimens should be reserved for patients with high-risk features.
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The improvement of resectability and survival observed in patients with colorectal liver metastasis treated by novel active chemotherapy was a major therapeutic step.. Recent results in HCC strongly support that similar expectations might be achieved to improve outcome by including neoadjuvant or adjuvant therapy.. Hepatocellular carcinoma (HCC) is a major cause of cancer mortality world- wide.
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Perioperative complications, such as bleeding, need for blood transfusion, need for portal triad clamping, and conversion to open resection, were higher in the hepatoma group as compared to patients with liver metastasis undergoing laparoscopic resection. Although this study demonstrated the feasibility of laparoscopic liver resection, it did not convince most physicians about a future role in HCC therapy..
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Loss of Fbxw7 expression is a predictor of recurrence in colorectal liver metastasis. https://doi.org/10.1002/jhbp.500.. Korphaisarn K, Morris VK, Overman MJ, Fogelman DR, Kee BK, Raghav KPS, et al. https://doi.org/10.18632/oncotarget.16848.. Li Q, Li Y, Li J, Ma Y, Dai W, Mo S, et al. FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1 α /CEACAM5 functional axis. https://doi.org/10.7150/ijbs.24505..
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The current study was a phase I, open-label, single- center, dose-escalation clinical trial to determine the dose limited toxicity (DLT), the maximum tolerated dose (MTD) and the recommended dose (RD) for phase II/III trials, as well as the preliminary antitumor effects of K-001 in patients with advanced PDAC. (4) above 28 days from the end of the last chemotherapy. 3.0 × ULN in patients without liver metastasis, or ALT and AST ≤ 5.0 × ULN in patients with liver metastasis). (6) a history of any
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Figure 11.25 Colon cancer liver metastasis. Figure 11.26 Mucinous Adenocarcinoma Metastatic Disease. Hepatic metastases are supplied by the hepatic artery, and two thirds of the liver is supplied by the portal vein.. MDCT (performed with IV contrast material during the portal vein phase of enhancement, 60–70 sec after the start of the bolus) typically shows heterogeneous, ring-enhancing metastases that are hypodense to the liver (Figure 11.25).
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Prophylactic hepatic arterial infusion chemotherapy for the prevention of liver metastasis in patients with colon carcinoma: a randomized control trial. Allen PJ, Nissan A, Picon A, et al. Bilchik AJ, Poston G, Curley S, et al. Vauthey JN, Pawlik TM, Ribero D, et al. Kesmodel SB, Ellis LM, Lin E, et al. Zorzi D, Laurent A, Pawlik TM, et al. Abulkhir A, Limongelli P, Healey A, et al. Covey AM, Brown K, Jarnagin W, et al. Jaeck D, Oussoultzoglou E, Rosso E, et al.
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Five metastasis-related mRNAs signature predicting the survival of patients with liver hepatocellular carcinoma. Backgrounds: Liver hepatocellular carcinoma (HCC) is one of the most malignant tumors, of which prognosis is unsatisfactory in most cases and metastatic of HCC often results in poor prognosis. In this study, we aimed to construct a metastasis- related mRNAs prognostic model to increase the accuracy of prediction of HCC prognosis..
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Alanine mutants of TWIST1 suppresses lung (A) and liver (B) metastasis of 4T1 cells. Glutamic acid mutants of TWIST1 convert nonmetastatic 67NR cells into metastatic cells.
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Hypervascular primary tumor (kidney, thyroid, and liver), wide or marginal exci- sion, metastasis at the lumbar spine, and the presence of extraosseous tumor mass were significantly associ- ated with blood loss.
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Stereotactic body radiotherapy for liver metastases.. New perspectives in the treatment of colorectal metastases. The role of interventional oncology in the treatment of colorectal cancer liver metastases. guidelines of the DEGRO working group on stereotactic radiotherapy.. Surgical treatment of hepatic colorectal metastasis: evolving role in the setting of improving systemic therapies and ablative treatments in the 21st century.