Tìm thấy 17+ kết quả cho từ khóa "Opioid receptors"
tailieu.vn Xem trực tuyến Tải xuống
Changes in opioid receptors in the PAG. The mRNA data were determined by the 2 –ΔΔCT method to estimate the expression of opioid receptors in the PAG relative to that in the control group. 3C) in the PAG. Furthermore, there were no significant changes in opioid receptor ex- pression in the D1 or D2 groups. Dezocine coadminis- tered with morphine (MD1 and MD2 groups) alleviated the morphine-induced downregulation of MOR expres- sion, especially in the MD2 group (Fig.
tailieu.vn Xem trực tuyến Tải xuống
This also might be attributed to the wide distribution of the opioid receptors in the limbic system and locus coer- uleus, which are deemed responsible for reward process- ing and mood control and mental activity [28].. Therefore, the speculated underlying mechanisms of improved mood caused by hydromorphone IV-PCA were associated with pain relief induced by the excited mu opioid receptors and the anti-anxiety and anti- depression caused by excited delta opioid receptors;.
tailieu.vn Xem trực tuyến Tải xuống
Airway opioid receptors mediate inhibition of cough and reflex bronchoconstriction in Guinea pigs. Mechanisms of capsaicin- and citric-acid-induced cough reflexes in Guinea pigs. Dezocine prevents sufentanil-induced cough during general anesthesia induction: a randomized controlled trial.. Effects of pretreatment with a small dose of dexmedetomidine on sufentanil-induced cough during anesthetic induction. Limited maximal flow rate of target-controlled remifentanil infusion and induced cough.
tailieu.vn Xem trực tuyến Tải xuống
In our study, we investigated the relationship between μ-Opioid receptor level and opioid analgesics and evalu- ated with post-operative pain and analgesic use. reported that there are the relationship between some tumor cells in the body and the anesthetic technique and μ-Opioid receptors.
tailieu.vn Xem trực tuyến Tải xuống
Previous studies have shown the impact of regional anesthesia on recurrence, migration, and immune response in breast cancer surgery [12–15], and some studies report that anesthesia drug promotes and increases cancer proliferation and migra- tion via opioid receptors [16, 17]. Here, in this study, we aimed to research the effects of OPRK1 in migration in breast cancer.
tailieu.vn Xem trực tuyến Tải xuống
Li Y, Li JJ, Yu LC (2002b) Anti-nociceptive effect of neuropeptide Y in the nucleus accumbens of rats: an involvement of opioid receptors in the effect. Brain Res 940:69–78. Liang D-Y, Li X, Clark JD (2004) Formalin-induced spinal cord calcium/calmodulin-dependent protein kinase IIa expression is modulated by heme oxygenase in mice. Liebmann C, Schrader U, Brantl V (1989) Opioid receptor affinities of the blood-derived tetrapeptides hemorphin and cytochrophin.
tailieu.vn Xem trực tuyến Tải xuống
Xu M, Petraschka M, McLaughlin JP, Westenbroek RE, Caron MG, Lefkowitz RJ, Czyzyk TA, Pintar JE, Terman GW, Chavkin C (2004b) Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance. Xu W, Lundeberg T, Wang YT, Li Y, Yu L-C (2003) Antinociceptive effect of calcitonin gene-related peptide in the central nucleus of amygdala: activating opioid receptors through amygdala-periaqueductal gray pathway.
tailieu.vn Xem trực tuyến Tải xuống
Chen JJ, Dymshitz J, Vasko MR (1997) Regulation of opioid receptors in rat sensory neurons in culture. Chen SR, Wess J, Pan HL (2005b) Functional activity of the M2 and M4 receptor subtypes in the spinal cord studied with muscarinic acetylcholine receptor knockout mice. Chen XH, Geller EB, Rogers TJ, Adler MW (2007) The chemokine CX3CL1/fractalkine interferes with the antinociceptive effect induced by opioid agonists in the periaqueductal grey of rats.. Brain Res 1153:52–57.
tailieu.vn Xem trực tuyến Tải xuống
Gao L, Yu LC (2004) Involvement of opioid receptors in the oxytocin-induced antinociception in the central nervous system of rats. Gardell LR, Ibrahim M, Wang R, Wang Z, Ossipov MH, Malan TP Jr, Porreca F, Lai J (2004) Mouse strains that lack spinal dynorphin upregulation after peripheral nerve injury do not develop neuropathic pain.
tailieu.vn Xem trực tuyến Tải xuống
Human brain imaging studies have implicated this pain-modulating circuit in the pain-relieving effect of attention, suggestion, and opioid analgesic medications. Furthermore, each of the component structures of the pathway contains opioid receptors and is sensitive to the direct application of opioid drugs.. In animals, lesions of the system reduce the analgesic effect of systemically administered opioids such as morphine.
tailieu.vn Xem trực tuyến Tải xuống
Blockade of opioid peptides from opioid receptors for a short period each day (4–6 h), using a daily admin- istration of low-dose naltrexone (LDH), provides an 18- 20 h window wherein the elevated levels of endogenous opioids and opioid receptors can interact to elicit a response [33]. According to the potency relationship between naltrexone and naloxone, low dose naloxone (4.5 mg) [35] in the report was far more than 0.05 μg·kg − 1 ·h − 1 naloxone we used in this study..
tailieu.vn Xem trực tuyến Tải xuống
Their side- effects on monocyte-endothelial adherence should be considered by clinicians.. 7 showed that the 3 main classes of opioid receptors, mu (MOR), kappa (KOR), and delta (DOR) were expressed on both HUVECs and U937 monocytes. In order to confirm the effects of μ-opioid receptors on U937-HUVECs adhesion, we used the selective antagonist of μ-opioid receptors, β-funaltrexamine, to pretreat U937 monocytes in Supple- mentary Fig.
tailieu.vn Xem trực tuyến Tải xuống
Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys
tailieu.vn Xem trực tuyến Tải xuống
The specificity studies showed that the agonist of opioid receptors, tramadol, did not intervene in the process of codeine detection by the fabricated aptasensor. This was predictable because the chemical structure of tramadol is completely different from that of codeine. 28 In the case of naloxone, an antagonist for the opioid receptors, although its chemical structure is very similar to codeine, 15,28 this molecule did not interact with the aptasensor, either.
tailieu.vn Xem trực tuyến Tải xuống
No lidocaine related incidence of anaphylaxis, systemic toxicity, circulatory disturbances or neurological impair- ment was reported, during anesthesia or 24 h after re- moval of the endotracheal tube.. opioid receptors, decrease excitability and conduction of unmyelinated C fibres, suppress polysynaptic reflexes in the spinal dorsal horn, stimulate muscarinic and nico- tinic receptors, and can also act on the cerebral level [10].
tailieu.vn Xem trực tuyến Tải xuống
Opioids are widely used in the induction and mainten- ance of general anesthesia, mainly through the action of opioid receptors (μ, κ, δ), and opioids have a strong an- algesic effect, fast onset, short duration, and reduction of cardiovascular response [1]. It is necessary to take effective measures to suppress the occurrence of SIC in general anesthesia..
tailieu.vn Xem trực tuyến Tải xuống
Of note, hydromorphone administered by target-controlled infusion and patient- controlled analgesia (PCA) to postoperative adult cardiac surgery patients improved mood, which is closely related to pain relief, likely due to the anti-anxiety and the anti- depression effects induced by activation of δ-opioid receptors. Sufentanil’s short duration of analgesia may be explained by its low affinity for the δ-opioid receptor and rapid redistribution [24]..
tailieu.vn Xem trực tuyến Tải xuống
Opioid receptors are part of the family of G-protein-coupled receptors (see p. The K-receptor is responsible for analgesia at the level of the spinal cord and is also associated with dysphoria. The role of the 8-receptor in humans is less clear.. In addition, a weak (low-efficacy) agonist (codeine) will compete with a high-efficacy opioid for receptors and so reduce the receptor occupancy, and therefore the therapeutic efficacy of the latter.
tailieu.vn Xem trực tuyến Tải xuống
The non-competitive NMDA antagonist MK-801 can be systemically adminis- tered to animals, and such administration has been shown to suppress the development of opioid depend- ence and opioid tolerance [21]. MK-801 can similarly in- hibit the onset of morphine withdrawal syndrome [22], interfere with the acquisition of cocaine self- administration behaviors [23], and alter conditioned place preference study outcomes [24].
tailieu.vn Xem trực tuyến Tải xuống
Opioid thường được dùng để giảm đau do ung thư, bệnh giai đoạn cuối, chấn thương nặng hoặc phẫu thuật. Giảm đau sau mổ là đặc biệt quan trọng. Opioid có nhiều dạng. Một giả thuyết đứng sau nhiều cách điều trị bổ sung và thay thế để giảm đau là chúng hoạt hoá những peptid opioid tự nhiên này trong não và tủy sống.. Tác dụng phụ của opioid gồm chóng mặt nhẹ, ngủ gật, buồn ngủ, an thần và tư duy không sáng suốt. Những tác dụng phụ này khiến bạn không an toàn khi lái xe hoặc vận hành máy.