Có 40+ tài liệu thuộc chủ đề "BMC Cancer"
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POstmastectomy radioThErapy in Node- posiTive breast cancer with or without Internal mAmmary nodaL irradiation (POTENTIAL): a study protocol for a multicenter prospective phase III randomized controlled trial. Background: Various randomized trials have demonstrated that postmastectomy radiotherapy (RT) to the chest wall and comprehensive regional nodal areas improves survival in patients with axillary node-positive breast cancer.. The results of this study...
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thromboembolism according to primary treatment type in women with endometrial cancer: a population-based study. Background: Current prophylaxes and treatments for venous thromboembolism (VTE) in women with gynecologic cancer are mainly guided by studies on solid cancers because studies in gynecologic cancer did not provide sufficient data. Large-scale studies evaluating the incidence and risk of VTE according to therapeutic modality may...
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The relationship between dairy products intake and breast cancer incidence: a meta- analysis of observational studies. Background: The effect of dairy products intake on breast cancer (BC) is highly controversial. Table 2 Effects of dairy products on breast cancer incidence. ER+ breast cancer . ER- breast cancer . PR+ breast cancer . PR- breast cancer . ER+/PR+ breast cancer ....
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Tryptophan metabolism induced by TDO2 promotes prostatic cancer chemotherapy resistance in a AhR/c-Myc dependent. Result: Comparing the tumor tissues from prostatic cancer patients, we found elevated expression of tryptophan 2, 3-dioxygenase 2 (TDO2), and elevated Trp metabolism in chemo-resistant tumor tissues. In vitro, overexpression of TDO2 significantly promoted the Trp metabolism in prostatic cancer cell lines LNCaP and VCap, resulting...
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The quality of life in women with cervical cancer and precancerous lesions of Han and ethnic minorities in Southwest China. Background: As patients with cervical cancer and precancerous lesions can be diagnosed at early stage and live longer, it is imperative to understand their health-related quality of life so that better cancer-related policies could be promoted and reasonable distribution of...
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Clinical verification of body mass index and tumor immune response in patients with breast cancer receiving preoperative. patients with early-stage breast cancer who are obese (OB) per BMI measurements have been shown to have high postoperative recurrence and low survival rates. Therefore, we hypothesized that OB patients with breast cancer have a lower density of tumor-infiltrating lymphocytes (TILs), which may...
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chemotherapy in selected populations of patients with treatment-naive unresectable hepatocellular carcinoma exhibiting PD-L1 staining: a multicenter retrospective study. Background: Not all patients with unresectable hepatocellular carcinoma (uHCC) benefit from treatment with immune checkpoint inhibitors and molecular-targeted agents. Methods: Consecutive patients with treatment-naive uHCC exhibiting PD-L1 staining who were treated with pembrolizumab plus lenvatinib plus HAIC (PLH) or pembrolizumab plus lenvatinib...
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Methods: In this study, the anti-cancer activities of BD0801 and its potential synergistic anti-tumor effects when combined with different immunotherapies were assessed by using in vitro assays and in vivo tumor models. Notably, combining BD0801 with either anti-PD-1 or anti-PD-L1 antibodies showed synergistic antitumor efficacy in both lung and colorectal cancer mouse models. Conclusions: These data provide a solid rationale...
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Pooled analysis of combination antiemetic therapy for chemotherapy-induced nausea and vomiting in patients with colorectal cancer treated with oxaliplatin-based chemotherapy of moderate emetic risk. Female and 2 antiemetics were risk factors for both delayed nausea (female — odds ratio [OR]: 1.918. Conclusions: Identifying individual risk factors can facilitate personalized treatments for delayed CINV. We recommend a 3-antiemetic combination prophylaxis for...
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Evaluating the impact of 18F-FDG-PET-CT on risk stratification and treatment. Thereby the presence of extra-vesical disease on 18 F-FDG-PET-CT has been correlated with a worse overall survival. This supports the hypothesis that 18 F-FDG-PET-CT is useful in stratifying MIBC patients and that adapting the treatment plan accordingly might result in improved outcome.. An 18 F-FDG-PET-CT will be performed in addition...
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In epithelial ovarian cancer (EOC), approximately 50% of cases involve HRD due to alterations of HRR pathway genes [21]. These breast and ovarian cancer cluster regions are shown below in Table 1. Individuals with this mutation are more prone to develop ovarian cancer than breast cancer. This mutation is associated with higher risk of ovarian cancer [39, 60]. An EMSY...
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Chronic fatigue, quality of life and long- term side-effects of chemotherapy in. patients treated for non-epithelial ovarian cancer: national case-control protocol study of the GINECO-Vivrovaire rare tumors INCa French network for rare malignant ovarian tumors. Background: Germ cell tumors and sex cord stromal tumors are rare cancers of the ovary. As reported in testicular cancer survivors, chemotherapy may induce sequelae...
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Disparity of perception of quality of life between head and neck cancer patients and caregivers. associated with a difference in how caregivers and their patients perceive patients ’ quality of life (QOL) after treatment completion.. Methods: Caregivers ’ and patients ’ perceptions of patient QOL were assessed using the University of Washington QOL Questionaire (UWQOL), a validated HNC-specific health-related QOL...
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Intraarterial contrast-enhanced ultrasound to predict the short-term tumour response of hepatocellular carcinoma to Transarterial chemoembolization with Lipiodol. The aim of this study was to predict the TR after TACE (1 – 3 months) in HCC patients using intraprocedural intraarterial contrast enhanced ultrasound (IA-CEUS).. Postoperative contrast-enhanced liver MRI was performed 1 – 3 months after TACE as the gold standard. The...
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progression in HNSCC. This study was to investigate its expression pattern, clinicopathological significance and biological roles in HNSCC.. Methods: HNSCC data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) was used to indicate the detailed expression pattern and outcome association of FOXD1, while Western Blot assay to detect FOXD1 level in a panel of HNSCC cell lines...
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Hotspot mutation profiles of AKT1 in Asian women with breast and endometrial. The clinicopathological features and frequencies in Asian populations with AKT1 mutations in breast and endometrial cancers are unclear. Hence, we aimed to determine the frequencies and relationships between clinicopathological features and AKT1 mutations in Asian women with cancer.. Methods: We extracted DNA from 311 and 143 samples derived...
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EBV-infected STAD and HPV- infected HNSC showed a higher frequency of the “ Immune-Stimulation ” subtype. Gene set variation analysis (GSVA) was implemented using the “GSVA” R package (3.8). Gene expressions (FPKM) were log2-transformed after adding one as the pseudo count and then processed by the “ limma ” R package (3.36.5). Enrichment analyses were per- formed using the “...
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adenocarcinoma – the phase III “ PREVENT. (FLOT9) trial of the AIO /CAOGI /ACO. with localized and locally advanced diffuse or mixed type (Laurens ’ s classification) adenocarcinoma of the stomach and Type II/III GEJ.. Full list of author information is available at the end of the article. with gastric cancer and no peritoneal involvement will not be treated with...
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The efficiency of 18 F-FDG-PET/CT in the assessment of tumor response to. preoperative chemoradiation therapy for locally recurrent rectal cancer. Background: Locally recurrent rectal cancer (LRRC) remains a major problem after curative resection of primary rectal cancer. This study assesses the effectiveness of PET/CT evaluation of preoperative chemoradiation therapy (CRT) in patients with LRRC.. chemotherapy: irinotecan plus UFT [tegafur and...
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Capsular extension at ultrasound is associated with lateral lymph node. Background: In patients with papillary thyroid cancer (PTC), cervical lymph node metastasis (LNM) must be carefully assessed to determine the extent of lymph node dissection required and patient prognosis. Few studies attempted to determine whether the ultrasound (US) appearance of the primary thyroid tumor could be used to predict cervical...