- Methods: We retrospectively analyzed 1515 MPA patients in SEER database. - Results: No significant differences were noted in OS and CSS time. - The MPA patients who were treated with surgery and chemotherapy exhibited longer OS and CSS time periods than those without treatment. - MPA patients treated with radiotherapy exhibited similar OS and CSS time with those without radiotherapy. - Conclusions: MPA was a rare histological type of gastric cancer. - Patients with MPA exhibited similar prognosis with those with CA. - Surgery and chemotherapy were effective treatments for patients with MPA.. - Gastric cancer (GC) is an important digestive cancer en- countered worldwide that ranks the fifth most frequently diagnosed cancer and the third leading cause of cancer death [1].. - To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.. - The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.. - The clinicopathological characteristics and the progno- sis of gastric MPA patients have been investigated in several studies. - It is important to state that signet ring cell carcinoma is associated with a favorable prognosis com- pared with other types of gastric cancer [19–22].. - In the present study, we retrospectively analyzed 1515 MPA gastric cancer pa- tients in the Surveillance, Epidemiology and End Results (SEER) database in order to compare the clinicopatho- logical characteristics and survival outcomes of MPA with CA.. - Clinicopathological data derived from gastric cancer pa- tients were collected from the SEER database (18 Regs Custom Data with additional treatment fields,, 1975–. - The patient information in the SEER database is anonymous and ethical consent was not required for using these data [23, 24].. - The Chi-square test was applied to determine the dif- ferences in the clinicopathological characteristics be- tween the MPA and the CA groups. - The log-rank test and Kaplan–Meier survival curve were applied to determine the differences in OS and CSS time periods between the MPA and the CA groups. - 1 Flowchart of the patients ’ selection process. - Boston MA, www.empowerstats.com) and R (http://www.R- project.org).. - The selection flow of the patients is shown in Fig. - The clinicopathological characteristics of the two groups are summarized in Table 1. - Overall, age, gender, race, tumor differentiation, clinical stage, T stage, N stage, surgery and chemotherapy were significantly dif- ferent between MPA and CA, i.e., patients in the MPA group exhibited younger, more females, more black people, more poor/undifferentiated tumors, later clinical stage, more T3, T4, N2 stages, more surgery and chemo- therapy than those of the CA group. - To investigate whether MPA patients exhibit different survival time with CA patient, we compared the OS and CSS time between the two groups. - The OS time in the MPA group was months, whereas that in the CA group was months. - The CSS time in the MPA group was months, whereas that in the CA group was 66 ± 1.13 months. - To further determine whether MPA patients show similar survival time with CA patient in different subgroup, we compared the survival curves. - Interestingly, for patients with poor/ undiffer- entiated tumor, clinical stage I, T1 and T2, MPA pa- tients had longer OS time than CA patients (p <. - To further determine whether MPA patients show simi- lar survival time with CA patient in different therapeutic. - 7, MPA patients had shorter CSS time than CA pa- tients after surgery, but there was no difference in OS time between the two groups. - MPA patients without surgery had shorter OS and CSS time than that in CA patients.. - MPA patients had similar OS and CSS time with CA pa- tients with or without radiotherapy/ chemotherapy.. - To investigate whether MPA patients obtained a sur- vival benefit from different clinical therapies, we com- pared the OS and CSS time periods. - 8, MPA patients who were treated with surgery. - exhibited longer OS and CSS time than those without surgery (both P <. - MPA patients treated with chemotherapy exhibited longer OS and CSS time than those without chemotherapy (both P <. - 2 Overall survival (OS) and cancer specific survival (CSS) analysis by different histological types of gastric cancer patients. - 3 Overall survival (OS) analysis by mucin-producing adenocarcinoma (MPA) and conventional adenocarcinoma (CA) in different clinicopathological groups of gastric cancer patients.. - and CSS time with those without radiotherapy (both P >. - Patients with CA obtained longer OS and CSS time when treated with surgery, chemotherapy and radiotherapy (All p <. - However, the prognosis of gastric cancer patients with MPA is still controversial and unclear. - Moreover, it has also been shown that signet ring cell carcinoma is associated with a favorable prognosis than other types of gastric cancer [19–22].. - Therefore, the present study retrospectively analyzed 1515 MPA gastric cancer patients from the SEER database in order to assess the prognostic value of MPA. - In the present study, the proportion of MPA in gastric cancer was approximately . - The proportion of CA in gastric cancer was approximately . - This evidence suggested that MPA was a rather rare histological type of gastric cancer. - The data indicated that patients in the MPA group were younger, more females, more black people, more poor/undifferentiated tumors, later clin- ical stage, more T3, T4, N2 stages, more surgery and chemotherapy than that of the CA group, which sug- gested that MPA was an aggressive histological type.. - No significant differences were noted in the OS and CSS time periods between the MPA and the CA groups, suggesting that gastric cancer patients with MPA had similar prognosis with those with CA.. - However, for patients with poor/ undifferentiated tumor, clinical stage I, T1 and T2, MPA patients had. - 4 Overall survival (OS) analysis by mucin-producing adenocarcinoma (MPA) and conventional adenocarcinoma (CA) in different clinicopathological stages of gastric cancer patients.. - MPA patients had shorter CSS time than CA patients after surgery, but there was no difference in OS time between the two groups. - MPA patients without surgery had shorter OS and CSS time than that in CA patients. - These results suggested that MPA patients had similar survival time with CA patients on the whole, but MPA was an ag- gressive histological type in some way. - The results were basic- ally in accordance with those from Zheng et al., who compared the CSS of esophageal cancer patients with MPA or CA and found similar survival time periods between the two groups [27].. - With regard to the treatment of MPA, the patients who were treated with surgery or chemotherapy had longer OS and CSS time periods than those without treatment, suggesting that surgery and chemotherapy were effective treatments for early and localized gas- tric cancer patients with MPA. - However, MPA pa- tients treated with radiotherapy exhibited similar OS and CSS time with those without radiotherapy in this study, which indicated that radiotherapy may not be an effective treatment for gastric cancer patients with. - However, pertinent information regarding radiotherapy was not available in the SEER database, which could have affected the results. - Therefore, fur- ther investigations are required to identify the prac- tical and clinical significance of radiotherapy for patients with MPA. - Secondly, due to the rarity of MPA cases and the exclusion of MPA patients with missing data, the number of patients with MPA used in the present study was low, compared with CA, which may affect the results in a way. - 5 Cancer specific survival (CSS) analysis by mucin-producing adenocarcinoma (MPA) and conventional adenocarcinoma (CA) in different clinicopathological groups of gastric cancer patients.. - 6 Cancer specific survival (CSS) analysis by mucin-producing adenocarcinoma (MPA) and conventional adenocarcinoma (CA) in different clinicopathological stages of gastric cancer patients.. - 7 Overall survival (OS) and cancer specific survival (CSS) analysis by mucin-producing adenocarcinoma (MPA) and conventional adenocarcinoma (CA) in different therapeutic groups of gastric cancer patients... - 8 Overall survival (OS) and cancer specific survival (CSS) analysis by clinical therapies in mucin-producing adenocarcinoma (MPA) and conventional adenocarcinoma (CA) gastric cancer patients. - Table 2 Univariate and multivariate analysis of overall survival for gastric cancer patients. - MPA is a rather rare histological type of gastric cancer.. - Patients with MPA had similar prognosis with those with CA. - Surgery and chemotherapy were effective treatments for gastric cancer patients with MPA.. - The authors thank SEER database for the public availability of the data.. - https://doi.org/10.3322/caac.21492.. - Pathological studies of human gastric cancer. - Gastric cancer histology: clinicopathologic characteristics and prognostic value. - https://doi.org/10.1002/jso.21150.. - Japanese Gastric Cancer Association. - Japanese gastric cancer treatment guidelines 2014 (ver. - Gastric Cancer. - https://doi.org/10.1 007/s . - Tumours of the digestive system. - Pathobiological behavior and molecular mechanism of signet ring cell carcinoma and mucinous adenocarcinoma of the stomach: acomparative study. - https://doi.org/10.3748/wjg.v10.i5.750.. - https://doi.org/10.1002/(SICI lt;1312::AID-CNCR7>3.0.. - Prognosis of sig-net ring cell carcinoma of the colon and rectum and their distinction of mucinous adenocarcinoma with signet ring cells. - https://doi.org/10.1097/SLA.0b013e3181b21c7b.. - https://doi.org/10.1007/s z.. - https://doi.org lt;698::A ID-CNCR1054>3.0.CO;2-O.. - Operable gastric adenocarcinoma with different histological subtypes: Cancer specifc survival in the United States. - https://doi.. - org/10.4103/sjg.SJG_406_19.. - https://doi.org/10.1002/jso.21533.. - https://doi.org/1 0.3892/mco.2014.447.. - Clinicopathological characteristics of signet ringcell carcinoma of the stomach. - https://doi.org/10.101 6/j.surg . - Clinicopathologic characteristics and prognosis of signet ring cell carcinoma of the stomach:. - https://doi.org/10.1002/jso.21878.. - Early signet ring cell gastric cancer. - https://doi.org/10.1007/s . - A Population-Based Study of the Incidence and Survival of Anorectal Gastrointestinal Stromal Tumor. - Proximal versus total gastrectomy for proximal gastric cancer: a surveillance, epidemiology, and end results program database analysis. - https://doi.org/10.2217/fon-2020-1071.. - org/10.1007/s . - A survival comparison of mucin-producing adenocarcinoma of the esophagus to conventional adenocarcinoma after Esophagectomy. - https://doi.org/10.1177/
Xem thử không khả dụng, vui lòng xem tại trang nguồn hoặc xem
Tóm tắt