Tìm thấy 20+ kết quả cho từ khóa "Muscle atrophy"
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Myostatin expression in age and denervation-induced skeletal muscle atrophy. Journal of Musculoskeletal &. Identification of ubiquitin ligases required for skeletal muscle atrophy. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo.. Journal of Cell Science . The American Journal of Physiology, 270, C1624–C1633..
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Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Effect of glucocorticoid excess on skeletal muscle and heart protein synthesis in adult and old rats. The British Journal of Nutrition . Necdin is expressed in cachectic skeletal muscle to protect fibers from tumor-induced wasting. Journal of Cell Science . International Journal of Cardiology . The American Journal of Physiology, 276, E50–E61..
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Some of the most compelling data examining the role of mitochondrial dysfunc- tion in age-related muscle atrophy has been the studies examining the co-localiza- tion of mitochondrial dysfunction and mitochondrial DNA (mtDNA) damage with focal regions of fiber atrophy and breakage along the length of individual muscle fibers in aged muscle (Lee et al.
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Aging and lifelong calorie restriction result in adapta- tions of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase 3, and caspase-12. The role of apoptosis in age-related skeletal muscle atrophy. Tumor necrosis factor alpha signaling in skeletal muscle:. The Journal of Nutritional Biochemistry . Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscle.
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In contrast to this, a recent paper by Trendelenburg et al.. presents data which indicates that myostatin induces atrophy through a mecha- nism involving inhibition of the Akt/TORC1/p70S6K signaling pathway (Trendelenburg et al. Another recent paper by Sartori et al., demonstrates that activation of the myostatin pathway, through transfection of constitutively active ALK5 into adult muscle fibres, results in muscle atrophy (Sartori et al. Interestingly, Sartori et al.
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In support of a role for apoptosis in age-related muscle atrophy, many studies have reported an increase in pro-apoptotic signaling in aged muscles (Alway et al. Giresi et al. On the other hand, differences in the degree of muscle atrophy between. 6 Succinate dehydrogenase and complex IV doubly-stained cross-section of muscle from a patient with heteroplasmic mtDNA mutation.
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Activation of the forkhead transcriptional program is necessary for induction of both muscle RING finger 1 (muRF1) and muscle atrophy F-box (MAFbx, also called atrogin-1) (Sandri et al. Both muRF1 and MAFbx encode ubiq- uitin ligases which conjugate ubiquitin to protein substrates, and are upregulated in numerous models of muscle atrophy (Bodine et al. Tintignac et al.
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Skeletal muscle atrophy is associated with an increased expression of myostatin and impaired satellite cell function in the portacaval anastamosis rat. Ectopic expression of myostatin induces atrophy of adult skeletal muscle by decreasing muscle gene expression. American Journal of Human Genetics . Loss of myostatin expression alters fiber-type distribution and expression of myosin heavy chain isoforms in slow- and fast-type skeletal muscle.
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In addition, genetic activation of Akt antagonizes signalling that leads to muscle atrophy: for example, over-expression of the constitutively active Akt was sufficient to block muscle wasting following short term (7 days) denervation (Bodine et al. transgenic muscle spe- cific over-expression of IGF-1 reduced the rate of atrophy resulting from denervation at 1 month, but not at 2 months following nerve transaction (Shavlakadze et al.
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Muscle wasting produced by TNF is associated with induction of oxidative stress (Tisdale 2005) that can modulate a complexity of interacting signalling pathways to result in muscle atrophy (Reviewed in (Arthur et al.
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Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy. Skeletal muscle proteolysis in aging. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle. Skeletal muscle loss: cachexia, sarcopenia, and inactivity. Sarcopenia and age-related changes in body composition and functional capacity
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Elevated core and muscle temperature to levels comparable to exercise do not increase heat shock protein content of skeletal muscle of physi- cally active men. Trained men display increased Basal heat shock protein content of skeletal muscle. Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 293, R1159–R1168..
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Skeletal muscle aging in F344BN F1-hybrid rats: I. Skeletal muscle aging in F344BN F1-hybrid rats: II. Long-term caloric restriction abro- gates the age-related decline in skeletal muscle aerobic function. The molecular basis of skeletal muscle atrophy. Association of age-related mito- chondrial abnormalities with skeletal muscle fiber atrophy.
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Cyclic nucleotide phosphodiesterase isozymes expressed in mouse skeletal muscle. Identification of ubiquitin ligases required for skeletal muscle atrophy. Akt/mTOR path- way is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Skeletal muscle in cancer cachexia: the ideal target of drug therapy. Effect of clenbuterol on recovery of muscle mass and car- cass protein content following experimental hyperthyroidism in old rats.
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Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. The Journal of the American Medical Association . Increased energy requirements and changes in body composition with resistance training in older adults. The American Journal of Clinical Nutrition . Muscular adaptations in response to three different resistance-training regimens:. European Journal of Applied Physiology .
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Rapid atrophy of the lumbar multifidus follows experimental disc or nerve root injury. tebral disc degeneration, paraspinal muscle atrophy, and lumbar facet joints degeneration in patients with lumbar disc herniation. eters of the paraspinal, uscles, spinal degeneration, and low back pain.. Magnetic resonance imaging of the discs and trunk muscles in patients with chronic low back pain and healthy control subjects. Storheim K, Berg L, Hellum C, Gjertsen Ø, Neckelmann G, Espeland A, et al.
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Proteomic analysis of the atrophying rat soleus muscle following den- ervation. Low Relative Skeletal Muscle Mass (Sarcopenia) in Older Persons Is Associated with Functional Impairment and Physical Disability. Journal of the American Geriatrics Society . Intracellular signaling during skeletal muscle atrophy..
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Some studies in humans directly relate this diminished strength to muscle atrophy (Kent-Braun and Ng 1999), while others find that it is greater than the decrease in muscle mass (Lynch et al. For example, the decline in nor- malized force (force/muscle mass, Nm/kg) in the knee extensors has been found to follow a curve, starting at about 40 years and declining by about 28% from 40–49 to 70–79 years (Lynch et al.
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Glucocorticoids seem to be involved in the emergence of muscle atrophy with advancing age (Dardevet et al. Savary et al. These hormones seem to interfere with other anabolic ones such as insulin or IGF-I (Dardevet et al. Vary et al. Sinaud et al. Some studies have suggested that exercise can delay the onset of muscle wasting in aged experimental animals (Mosoni et al. Lambert et al. 4 Diferential factors involved in sarcopenia and cachexia.
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Motor findings (focal weakness, muscle atrophy, or fasciculations) occur less frequently than focal sensory or reflex changes. Symptoms and signs are usually unilateral, but bilateral involvement does occur with large central disk herniations that compress multiple descending nerve roots within the spinal canal. Clinical manifestations of specific nerve root lesions are summarized in Table 16-2.