Tìm thấy 20+ kết quả cho từ khóa "Muscle wasting"
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The role of b -adrenoceptor signal- ing in skeletal muscle: therapeutic implications for muscle wasting disorders. Emerging drugs for sarcopenia: age-related muscle wasting. Update on emerging drugs for sarcopenia – age-related muscle wasting.. Therapeutic approaches for muscle wasting disorders. Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness. Proceedings of the National Academy of Sciences of the United States of America .
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Age-Related Muscle Loss. and Skeletal Muscle Wasting – Implications for Sarcopenia. Role of Contraction-Induced Injury in Age-Related Muscle. Role of IGF-1 in Age-Related Loss of Skeletal Muscle Mass. Role of Myostatin in Skeletal Muscle Growth and Development:. Role of b-Adrenergic Signalling in Skeletal Muscle Wasting:
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There is an urgent need to better understand the mechanisms underlying age-related muscle wasting and to develop therapeutic strategies that can attenuate, prevent, or ultimately reverse skeletal muscle wasting and weakness..
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The main factors that contribute to the malnutri- tion commonly observed in geriatric patients. 21 Muscle Wasting in Cancer and Ageing: Cachexia Versus Sarcopenia. 3.3 Age-Related Muscle Wasting: Mechanisms. Solutions to the major problems of dealing with age-related diseases can only come from a systematic and thorough molecular analysis of the ageing process and a detailed understanding of its causes. Some of the mechanisms and determinants involved in muscle wasting (Fig.
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In this chapter we describe the physiological significance of b-adrenergic signalling in skeletal muscle and discuss the therapeutic potential of b-adrenergic stimulation for age-related muscle wasting and weakness. skeletal muscle.
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IGF-1 is crucial for muscle formation and growth during embryogenesis and post- natal development, whereas insulin is more important for metabolism in the post- natal and adult states. In skeletal muscle, IGF-1 is closely involved in muscle growth, hypertrophy and maintenance of muscle mass (Fig. however, the role of IGF-1 in age-related muscle wasting is unclear and is the focus of the present dis- cussion.
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The prolonged absence of myostatin maintains the increased satellite cell number and activation even in aged muscle (Siriett et al. Therefore we propose that lack or inactiva- tion of myostatin would lead to increased self-renewal of satellite cells and efficient replacement of lost muscle fibres, leading to increased muscle growth and reduced muscle wasting. Grimby et al. Larsson et al.
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This increase in serum myostatin correlated with a decrease in muscle weights as compared with controls (Hosoyama et al. Cushing’s syndrome is associated with an excessive increase in glucocorticoid production resulting in skeletal muscle wasting (Shibli-Rahhal et al. Ma et al. The Dexamethasone-induced up-regulation of myostatin was inhibited in the presence of glucocorticoid antagonist RU-486 (Ma et al.
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The benefits of over-expression of IGF-1 on age-related muscle wasting have started to be tested in transgenic animal models (Chakravarthy et al. Musaro et al. Transgenic over-expression of IGF-1, as well as its down- stream target Akt, results in muscle hypertrophy (Bodine et al. Chakravarthy et al.
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This chapter has provided evidence for the importance of b-adrenergic signalling in skeletal muscle and implicated this pathway as a potential target for the treatment of age-related muscle wasting and weakness.
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Tetrodotoxin resistant action potentials in denervated rat skeletal muscle. L-type Ca2+ channel-insulin-like growth factor-1 receptor signaling impairment in aging rat skeletal muscle. Overexpression of IGF-1 exclusively in skeletal muscle prevents age-related decline in the number of dihydropyridine receptors.. Cellular and molecular mechanisms underlying age- related skeletal muscle wasting and weakness. Pflugers Archives- European Journal of Physiology .
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Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy. Role of b-adrenoceptor signaling in skeletal muscle: implica- tions for muscle wasting and disease. b-Adrenergic receptor distribution among muscle fiber types and resistance arterioles of white, red, and intermediate skeletal muscle. Nur77 regulates lipolysis in skeletal muscle cells.
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Satellite cell content is specifically reduced in type II skeletal muscle fibers in the elderly.. Canadian Journal of Applied Physiology . Contributions of the ubiquitin-proteasome pathway and apoptosis to human skeletal muscle wasting with age.. Abstract Skeletal muscle is one of the most heritable quantitative traits studied to date, with heritability estimates ranging from 30% to 85% for muscle strength measures and 50–80% for lean mass measures.
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Contrary to this, elevated MuRF1 mRNA levels have been found in skeletal muscle of women aged 85 years compared to 23 year old women (Raue et al. 2007) compared with other sarcopenia studies (Leger et al. Muscle wasting in aged rats does not appear to be due to reduced protein synthesis which suggests protein degradation is elevated (Kimball et al. In contrast, studies in healthy elderly humans do not show a reduction in basal protein synthesis or degradation rates (Volpi et al.
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The age-related loss of skeletal muscle mass is facilitated by a combination of fac- tors, which include a less than optimal diet (Campbell and Evans 1996. Campbell et al. The progressive muscle wasting during aging must be due to a disruption in the regula- tion of skeletal muscle protein turnover, leading to a structural imbalance between muscle protein synthesis and degradation.
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Quantitative-determination of myosin and actin in rabbit skeletal-muscle. Sarcopenia – Age-Related Muscle Wasting and Weakness,. Abstract Aging is associated with decreasing strength that can lead to impaired performance of daily living activities in the elderly.
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A number of studies have confirmed an aging-related slowing of the isometric twitch both at the whole muscle and motor unit levels in various mammals, including man (for refs.. An aging-related slowing of the isometric twitch is seen before the senile muscle wasting becomes manifest (Ansved and Larsson 1989;.
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Muscle wasting produced by TNF is associated with induction of oxidative stress (Tisdale 2005) that can modulate a complexity of interacting signalling pathways to result in muscle atrophy (Reviewed in (Arthur et al.
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A better understanding of the role of cytokines interfering with the molecular mechanisms accounting for protein wasting in skeletal muscle is essen- tial for the design of future effective therapeutic strategies. Cancer cachexia is regulated by selective targeting of skeletal muscle gene products.. The Journal of Clinical Investigation . Apoptosis in skeletal muscle. Skeletal muscle apoptosis and weight loss in chronic obstructive pulmonary disease..
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The ‘wasting’ or ‘atrophy’ of a skeletal muscle refers to a loss in the mass of the skeletal muscle, a condition that arises from a reduced usage of skeletal muscles at any age. In addition, by 70–80 years of age an outright loss of skeletal muscle fibers occurs that is estimated, based on data from vastus lateralis muscles, to be as high as 50% of the fibers (Lexell et al.