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Neuromuscular blocking agents

Tìm thấy 18+ kết quả cho từ khóa "Neuromuscular blocking agents"

Is lower-dose sugammadex a cost-saving strategy for reversal of deep neuromuscular block? Facts and fiction

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Therefore, antagonism of neuromuscular blocking agents is essential when using these drugs, and the ap- propriate drug and dose should be based on assessment of objective (quantitative) neuromuscular monitoring..

Economic impact of improving patient safety using Sugammadex for routine reversal of neuromuscular blockade in Spain

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Rocuronium and cisatracurium are the neuromuscular blocking agents included in the model, as vecuronium is not available in our country, representing more than 90% of the market. cisatracurium was used were switched to rocuronium in the alternative scenario using sugammadex as reversal agent. According to the prospective observational study by Martinez-Ubieto et al.

Carboxymethyl-γ-cyclodextrin, a novel selective relaxant binding agent for the reversal of neuromuscular block induced by aminosteroid neuromuscular blockers: An ex vivo laboratory study

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Concentra- tion–response relationships were constructed for the neuromuscular blocking agents rocuronium, pipecuronium, and vecuronium. The half-effective concentrations of sugammadex and carboxymethyl-γ-cyclodextrin for reversal of neuromuscular block were determined.. The half effective concentrations (95% CI) of carboxymethyl-γ-cyclodextrin and sugammadex were μM and μM, respec- tively, for the reversal of rocuronium-induced block.

Recovery and prediction of postoperative muscle power – is it still a problem?

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Abbreviations: PACU Post anaesthetic care unit, SpO 2 pulse oximetric saturation, NMBA neuromuscular blocking agents Plus minus value: mean ± SD, p-values displayed in Tables 3 and 6. p<0.0001 r 2 =0.40. p<0.0001 r 2 =0.33. 1 Muscle power/pulse oximetric saturation.

Comparison of neuromuscular blockade recovery co-administered with neostigmine and different doses of calcium gluconate: A randomized control trial

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However, in addition to the pharmacodynamics between non-depolarizing neuromuscular blocking agents (NMBAs) and AchEIs, factors such as electrolyte abnormalities, anticholinester- ase administration timing, body temperature, drug dosage, additional medications, and liver or kidney disease also affect neuromuscular recovery [4].

Neuromuscular block in patients 80 years and older: A prospective, controlled study

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Avoidance of neuromuscular blocking agents may increase the risk of difficult tracheal intubation: a cohort of 103,812 consecutive adult opatientsrecorded in the Danish Anaesthesia Database. Fuchs‑Buder T, Schmartz D, Baumann C, et al. Residual curarization in the recovery room after vecuronium. Residual neuromuscular block: Lessons unlearned.. Part 1: Definitions, incidence, and adverse physiologic effects or residual neuromuscular block. Berg H, Roed J, Viby‑Mogensen J, Mortensen CR, et al.

Respiratory muscle activity after spontaneous, neostigmine- or sugammadex-enhanced recovery of neuromuscular blockade: A double blind prospective randomized controlled trial

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The use of neuromuscular blocking agents (NMBAs), their reversal agents and respiratory outcome after surgery is still the subject of research and debate [1, 2]. In previous studies, we found lower diaphragmatic activity after neostigmine rever- sal of a NMB, compared to sugammadex [9, 10]. In this study, we wanted to assess the effect of com- monly used degrees of NMB and their possible reversal strategies on respiratory muscle activity after the return of normal neuromuscular transmission.

Lidocaine combined with magnesium sulfate preserved hemodynamic stability during general anesthesia without prolonging neuromuscular blockade: A randomized, double-blind, controlled trial

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Drugs such as lidocaine and magnesium sulfate are frequently used in combination with neuromuscular blocking agents (NMBAs) [6], the latter of which may contribute to residual neuromuscular blockade (NMB).. Magnesium sulfate infusion administered before anesthesia has been found to increase the speed of onset of a rocuronium-, cisatracurium- or vecuronium- induced NMB without necessarily enhancing its duration [13, 14].

Comparison of the effects of sugammadex and neostigmine on hospital stay in robotassisted laparoscopic prostatectomy: A retrospective study

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Keywords: Hospital length of stay, Neuromuscular blocking agents, Reversal agents, Rocuronium, Sugammadex. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material.

Comparison of emergence agitation between succinylcholine and rocuroniumsugammadex in adults following closed reduction of a nasal bone fracture: A prospective randomized controlled trial

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Second, although the succinylcholine and rocuronium doses used in this study correspond to the typical doses recommended to facilitate intubation, the different depth of neuromuscular block between the groups may have affected EA. In our study, the difference in duration of action between the two neuromuscular blocking agents resulted in more frequent PVD in group SC than in group RS (23.8% vs.. Group SC ( n = 21) Group RS ( n = 21) Mean difference or RR (95% CI) P In operating room.

Anaesthesia for a biopsy of corpus callosum in patient with a recent intraoperative anaphylaxis to an unknown anaesthetic allergen: A case report

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One of the advantages of awake flexible endoscopic in- tubation is the lack of need for the use of neuromuscular blocking agents as there is a priority to secure the defini- tive airway while maintaining spontaneous ventilation..

Effects of hyperthermia on the effective concentration of rocuronium and sugammadex-mediated reversal in isolated phrenic nerve hemidiaphragm preparations of rats

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In general, body temperature decreases during anesthesia due to the administration of anesthetic agents and the en- vironment of the operating room [1, 2]. Changes in body temperature during an operation result in changes in the pharmacodynamics of drugs such as neuromuscular blocking agents or agents that reverse neuromuscular blockade (NMB) such as sugammadex..

Comparison of the trapezius and the adductor pollicis muscle as predictor of good intubating conditions: A randomized controlled trial

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Conclusions: Performing acceleromyography at the trapezius muscle reduced the time between injection of neuromuscular blocking agents and intubation by 18 s (11. Thus, trapezius muscle acceleromyography is an acceptable alternative to adductor pollicis muscle acceleromyography in predicting acceptable intubating conditions, which allows for earlier indication of adequate intubating conditions..

Preparing for the unexpected: Special considerations and complications after sugammadex administration

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Non-steroidal neuromuscular blocking agents to re-establish paralysis after reversal of rocuronium-induced neuromuscular block with sugammadex. The use of succinylcholine after sugammadex reversal.. Three suspected cases of sugammadex-induced anaphylactic shock. Anaphylaxis after sugammadex administration. Effects of sugammadex on activated partial thromboplastin time and prothrombin time in healthy subjects.

Critical Care Obstetrics part 65

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Canadian survey of the use of sedatives, analgesics, and neuromuscular blocking agents in critically ill patients . Use of amiodarone during pregnancy . during pregnancy . Use of glucagon to treat neonatal low - output congestive heart failure after maternal labetalol therapy . The use of intravenous nitroglycerin for cervico - uterine relaxation: a review of the literature . Clinical report on the use of sodium nitroprusside in severe pre - eclampsia .

The optimal dose of succinylcholine for rapid sequence induction: A systematic review and meta-analysis of randomized trials

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According to good clinical research practice in pharma- codynamic studies of neuromuscular blocking agents [9], excellent, good or unacceptable intubating conditions may be distinguished. Excellent intubating conditions are present when all variables of the intubating score (ease of laryngoscopy, vocal cord position and move- ment, airway reaction, movement of limbs) are rated as excellent.

Antinociceptive effects of magnesium sulfate for monitored anesthesia care during hysteroscopy: A randomized controlled study

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Magnesium sulphate is known to prolong and potentiate neuromuscular block by non-depolarizing neuromuscular blocking agents [27]. Patients in our study did not receive muscle relax- ant and they keep breathe spontaneously. Different surgical model may explain the diverse results on the time of recovery of consciousness between the present study and the result of Altan et al.. Intravenous administration of magnesium generally is associated with minor side effects.

Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 38)

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Th e drugs of the peripheral type are also called neuromuscular blocking agents. Th e peripheral- acting muscle relaxants are being used for muscle relaxation upon endotracheal intubation and/or general anaesthesia for surgical operation. Th e central-acting muscle relaxants are used for treat- ments of painful muscle contracture caused by locomotorial disorders, and for relaxation of mus- cle stiff ness caused by psychotic tension or by neurosis.

Usefulness of intra-operative neuromuscular blockade monitoring and reversal agents for postoperative residual neuromuscular blockade: A retrospective observational study

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The re- ported incidence varies from 20 to 50% in the posta- naesthesia care unit (PACU), depending on the TOFR threshold (0.7 or 0.9) used to define RNMB in each study, type of neuromuscular blocking drugs (NMBDs) used, and the use of objective or intra-operative quanti- tative monitoring of neuromuscular function [3].. In an online sur- vey, 15% of anaesthesiologists in the United States and Europe reported that they had never observed an epi- sode of RNMB in their patients [5].

Postoperative complications with neuromuscular blocking drugs and/or reversal agents in obstructive sleep apnea patients: A systematic review

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Residual neuromuscular blockade: incidence, assessment, and relevance in the postoperative period. Baillard C, Clec ’ h C, Catineau J, Salhi F, Gehan G, Cupa M, et al.. Eikermann M, Vogt F, Herbstreit F, Vahid-Dastgerdi M, Zenge MO, Ochterbeck C, et al. Grosse-Sundrup M, Henneman JP, Sandberg WS, Bateman BT, Uribe JV, Nguyen NT, et al. Residual neuromuscular blockade:. Moher D, Larissa S, Clarke M, Ghersi D, Liberati A, Petticrew M, et al..