« Home « Kết quả tìm kiếm

Pyrimidine derivatives

Tìm thấy 11+ kết quả cho từ khóa "Pyrimidine derivatives"

Metal- and solvent-free preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by deep eutectic solvents

tailieu.vn

To characterize the structure of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives,. 1 H-NMR and 13 C-NMR were recorded on a Bruker Advance II 500 MHz NMR spectrometer using DMSO-d 6 as solvent (Table 3).. The spectral data of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives..

Synthesis, reaction, and evaluation of the anticancer activity of 6,7,8,9-tetrahydro-5H -cyclohepta[4,5]selenopheno[2,3-d]pyrimidine derivatives

tailieu.vn

Synthesis, reaction, and evaluation of the anticancer activity of. 6,7,8,9-tetrahydro-5 H -cyclohepta[4,5]selenopheno[2,3-d ]pyrimidine derivatives. The reaction of 6 with phosphorus oxychloride produced 4-chloro-6,7,8,9-tetrahydro-5H -cyclohepta[4,5] seleno[2,3- d]pyrimidine (12), the key compound for our nucleophilic substitution reactions.

Recent synthetic methodologies for pyrimidine and its derivatives

tailieu.vn

Synthesis of pyrimidine derivatives 174 and 176.. described the synthesis of different pyrimidine derivatives 183 (anticancer agents) by treating ketones 183 with acetamidines 22/guanidine 50 (Scheme 52). Preparations of pyrimidine derivatives.. Synthetic layout for the synthesis of pyrimidine derivatives 193..

Synthesis and in vitro anticancer evaluation of 1,4-phenylene-bis-pyrimidine-2-amine derivatives

tailieu.vn

General procedure for the synthesis of bis-pyrimidine derivatives (5a–5h).

Synthesis and molecular docking studies of quinoline derivatives as HIV non-nucleoside reverse transcriptase inhibitors

tailieu.vn

SAR studies of the synthesized compounds were also performed based on their docking scores, which revealed that in the case of pyrimidine derivatives, a phenyl ring with an electron-withdrawing bromo group and a free amino group (attached to the pyrimidine ring) showed better binding affinity. In the case of pyrazoline derivatives, naphthalene attached to the pyrazoline ring showed better results compared to the p-Br-phenyl ring.

New protocols for the synthesis of 5-amino-7-(4-phenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate esters using an efficient additive

tailieu.vn

The preparation of 1,2,4-triazolo[1,5-a]pyrimidine derivatives demonstrated the efficiency of TMDP as a high recyclable additive and dual solvent catalyst. (c) there is a simple separation of the catalyst or solvent/catalyst and desired products. 1 H NMR of TMDP fresh. 1 H NMR of TMDP after 10 th run. 1 H NMR of TMDP fresh (up) and 1 H NMR of TMDP after 10 th run (down)..

Biotechnology and food sciences, Design and synthesis of novel pyrimidine analogs as anti tubercular agents targeting thymidine kinase domain

tailieu.vn

In the present investigation, different pyrimidine derivatives were designed, synthesized and screened for their in silico properties such as physicochemical, druglikeness, and ADMET and the toxic-less compounds were docked and aligned to the active pockets of the TMPKmt enzyme.

4,4’-trimethylenedipiperidine as a nitrogen heterocycle solvent and/or catalyst: Liquid phase tandem Knoevenagel–Michael condensation

tailieu.vn

Synthesis of pyrano[2,3‐d]pyrimidine‐2,4‐diones and pyridino[2,3‐d]. doi: 10.1002/. doi: 10.1016/j.. Synthesis of pyrazolo[4,3:5,6]pyrano[2,3-d]pyramidine derivatives for antiviral evaluation. doi: 10.1002/ardp.200700005. Activated nitriles in heterocyclic synthesis: synthesis of new[1]benzopyrano[3′,4′:5,6]pyrano[2,3-d]pyrimidine and [1]benzopyrano[3′,4′:5,6]pyrano [3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives with promising antibacterial activity. doi: 10.1016/.

Synthesis, biological evaluation of antioxidant-antibacterial activities and computational studies of novel anthracene- and pyrene-based Schiff base derivatives

tailieu.vn

Pyrazolo[3,4-d] pyrimidine derivatives containing a Schiff base moiety as potential antiviral agents. Inhibition of HIV-1 nuclear import via schiff base formation with arylene bis(methylketone). Synthesis, interaction with DNA and antiproliferative activities of two novel Cu (II) complexes with Schiff base of benzimidazole. Journal of Fluorine Chemistry 2013. Journal of Molecular Structure 2016. Thai Journal of Pharmaceutical Sciences 2010. Arabian Journal of Chemistry 2013.

Synthesis of new pyrazole and antibacterial pyrazolopyrimidine derivatives

tailieu.vn

In this case, we considered that the presence of amidine moiety may ensure the possibility of closure of the pyrimidine ring, resulting in novel derivatives of pyrazolo[3,4-d ]pyrimidine of significant biological interest since such compounds are substituted analogues of the well-known drug allopurinol.

Tetrahydropyridine: A promising heterocycle for pharmacologically active molecules

tailieu.vn

The majority of the derivatives in this series demonstrated antiproliferative activities and colon cancer cell line WiDr was more sensitive to these compounds. 17 Aeluri et al. 58 Styryl deriva- tives (compounds 54–57) of 4,6,6-trimethyl-2-oxo-1,2,5,6-tetrahydropyridines-3-carbonitriles were synthesized by Lukevics et al. 60 Newly synthesized 1,2,3,6-tetrahydropy- ridinyl-pyrimidine derivatives by Kamei et al. 61 Conway et al.

Bis(indoline-2,3-diones): versatile precursors for novel bis(spirooxindoles) incorporating 4H-chromene-3-carbonitrile and pyrano[2,3-d]pyrimidine-6-carbonitrile derivatives

tailieu.vn

Abstract: Multicomponent reaction of dimedone or 1,3-dimethylbarbituric acid and malononitrile with a series of bis(indoline-2,3-diones) afforded the corresponding bis(2-amino-7,7-dimethyl-2’,5-dioxo-5,6,7,8-tetrahydrospiro[chromene- 4,3’-indoline]-3-carbonitrile) and bis(7’-amino-1’,3’-dimethyl-2,2’,4’-trioxo tetrahydrospiro[indoline-3,5’-pyrano [2,3-d]pyrimidine]-6’-carbonitrile) derivatives in good to excellent yield..

Microwave assisted, sequential two-step, one-pot synthesis of novel imidazo[1,2-a] pyrimidine containing tri/tetrasubstituted imidazole derivatives

tailieu.vn

Catalytic synthesis of 1,2,4,5-tetrasubstituted 1H-imidazole derivatives: State of the art. doi: 10.1002/adsc.201801381. doi: 10.1039/c5nj00050e. Catalytic procedures for multicomponent synthesis of imidazoles:. 10.1039/c2gc35277j.

Biological evaluation and synthesis of new pyrimidine-2(1H)-ol/-thiol derivatives derived from chalcones using the solid phase microwave method

tailieu.vn

APT-NMR (100 MHz, CDCl 3 –CD 3 OD (20:1, δ , ppm): 117.59 (pyrimidine-CH pyrimidine-C 2/4/6. 1 H NMR (400 MHz, CDCl 3 –CD 3 OD (20:1, δ , ppm): [ar-H: 6.90 (m, 1H m, 2H), 6.94 (d, 2H, J = 8.0 Hz), 7.30 (bs, 1H), 7.98 (d, 2H, J = 8.0 Hz. APT-NMR (100 MHz, CDCl 3 –CD 3 OD (20:1, δ , ppm): 115.72 (pyrimidine-CH pyrimidine-C 2/4/6. 3296 (–OH), 1545 (C=C, aromatic ring), 1596 (C=N) 1235 (–OCH 3. 1 H NMR (400 MHz, CDCl 3 –CD 3 OD (20:1, δ , ppm): 4.01 (s, 3H, –OCH 3.

Efficient synthesis and antifungal investigation of nucleosides’ quaternary ammonium salt derivatives

tailieu.vn

Under conditions analogous to those for thymidine derivatives, in the case of uridine derivatives we have not been able to achieve any product. Only in the case of trimethylamine and pyridine were the desired salts obtained by sonication..

Synthesis and in vitro cytotoxic activity of novel pyrazolo[1,5-a]pyrimidines and related Schiff bases

tailieu.vn

derivatives and Schiff bases based on 5-aminopyrazole derivatives, and also investigation of the cytotoxic activities of the synthesized compounds against four human tumor cell lines (HCT116 “colon”, A549 “lung”, HepG2 “liver”, and MCF-7 “breast” cancers)..

Environmentally green synthesis of thioformamide derivatives

tailieu.vn

The thioacid derivatives 1 with isocyanides 2 in H 2 O reacted together in a 1:1 ratio at room temperature to produce thioformylamide derivatives 3a–d and thioformamide derivatives 4e–h (Scheme 1. Reactions of thiobenzoic acid with tert-butyl isocyanide, and thioacetic acid with benzyl isocyanide, 1,1,3,3-tetramethylbutyl isocyanide, and tertbutyl isocyanide produced thioformamide derivatives 4e–g.

Synthesis of fused tetrazolone derivatives

tailieu.vn

Abstract: New fused tetrazolone derivatives were synthesized using homophthalic and maleic anhydrides. The intermediates partially underwent internal 1,3-dipolar cycloaddition to produce fused tetrazolone derivatives.

Lecture Calculus - Chapter 32: Computing Anti-derivatives

tailieu.vn

COMPUTING ANTI-DERIVATIVES (Integration by PARTS. The computation of anti-derivatives is just an in-tellectual challenge, we know how to take deriv-atives, but. can we invert the process? We call this. derivative of many functions! We are going to try and do better. integration as inverse processes, that is, if we apply each in order we end up. (essentially) where we started.. First D then I gives us “where we started + C”. First I then D gives us “where we started.”.

QSAR study of chalcone derivatives as anti-Leishmania agents

tailieu.vn

QSAR study of chalcone derivatives as anti-Leishmania agents. Abstract:Quantitative structure activity relationship analyses were used to identify the ideal physicochemical character- istics of potential chalcone derivatives as anti-Leishmania agents.