Có 11+ tài liệu thuộc chủ đề "Anticancer activity"
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The cytotoxicity of all the title compounds were evaluated as per the National Cancer Institute protocol in a one-dose assay (10 µ M) on nine different panels of 59 cancer cell lines. Key words: Anticancer activity, cancer cell lines, cytotoxicity, one dose assay, oxadiazole, triazole. 1 In new cancer cases and 609,640 cancer deaths are projected to occur in the...
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Compound 14 (Figure 2) exhibited prominent activity against the HTB26 and MCF7 cell lines, having IC 50 values of 14 µM for both. The anticancer activity of the dendrimers was evaluated and significant efficacy was observed for piperazine-terminated organo-iron dendrimers against HTB26 and MCF7 cancer cell lines with IC 50 values of 3.6 µM and 2.5 µM, respectively. The cytotoxicity...
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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by- nc-nd/4.0/).. https://doi.org/10.1016/j.jsamd . This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).. Obtained powder samples of GOH-7, GOH-14, GOH-Sn-2, and GOH-Cr-1 were investigated for structural and phase analysis by X- ray diffraction (Rigaku Ultima-III) using Cu-K a radiation ( l ¼ 1.5406 A. After 24...
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R f : 0.52 (n -hexane/ethyl acetate. 1 H NMR (400 MHz, CDCl 3 ) δ 8.09 (d, J = 9.5 Hz, 2H), 8.00 (d, J = 8.0 Hz, 2H), 7.56 (m, 6H), 5.79 (dd, J Hz, 1H, CH-SO 2. 5.31 (d, J = 17.0 Hz, 1H), 5.07 (d, J = 17.0 Hz, 1H), 4.08 (dd,J Hz, 1H, CH 2...
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doi:10.3906/kim-1410-25 h t t p. Most of the tested compounds exhibited promising activity.. Mechanism of the synthesis of pyridine derivatives 6a–e and 8a–e.. We extended our protocol to the synthesis of bipyridine derivatives (10–12) via reacting 5-acetylimidazole 1 (1.0 mmol) with terephthaldehyde (0.5 mmol), malononitrile (or ethyl cyanoacetate or diethyl malonate) (1.0 mmol) under optimized conditions to give the corresponding...
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The structure of compounds 8a–l was further confirmed by the reaction of 3 with the appropriate active chloromethylenes 11a–c followed by coupling of the products with benzenediazonium chloride to afford the azo-coupling products 6b, f, and j, which were converted in situ to 8b, f, and j. Oxidative cyclization of the hydrazones 15a–f give the corresponding triazolo[4,3-a ] pyrimidin-5(1H) -one...
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The antiproliferative and cytotoxic activities of C1 and C2 were significantly lower than those of free anions, indicating that the extreme cytotoxicity of free anions decreased to safe levels in C1 and C2 . This paper shows a new class of silver and gold complexes denoted as C1 and C2 , which were tested for their anticancer activity against rat...
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1 H NMR 8.0-10.16 ppm. Yellow solid, yield (0.53 g, 60. 6.92 (d, J = 9.0 Hz, 2H, Ar-H), 7.29 (d, J = 9.0 Hz, 2H, Ar-H), 10.29 (s, 1H, NH). H, 3.11. H, 3.29. Yellow solid, yield (0.62 g, 73. H, 3.25. H, 3.47. Yellow solid, yield (0.65 g, 76. 6.8–7.18 (m, 4H, Ar H), 10.32 (s, 1H, NH)....
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Synthesis, reaction, and evaluation of the anticancer activity of. 6,7,8,9-tetrahydro-5 H -cyclohepta[4,5]selenopheno[2,3-d ]pyrimidine derivatives. The reaction of 6 with phosphorus oxychloride produced 4-chloro-6,7,8,9-tetrahydro-5H -cyclohepta[4,5] seleno[2,3- d]pyrimidine (12), the key compound for our nucleophilic substitution reactions. Anticancer activities of the synthesized compounds were investigated against the MCF-7 breast cancer cell line and the IC 50 values of these compounds were in...
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1,4-phenylene-bis-pyrazolylthiazole derivatives. In this study, novel 1,4-phenylene-bis-N-thiocarbamoylpyrazoles (3a–h) and 1,4-phenylene-bis-pyrazolylthiazoles (5a–h) were prepared and screened for their anticancer activities against C6 (rat brain tumor cells) and HeLa (human uterus carcinoma). Moreover, compounds 3a–h had lower cytotoxicity than 5-FU. The low cytotoxicity values of 3a–h as well as their high antiproliferative activity were encouraging, but further studies are required on the...
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Synthesis and in vitro anticancer evaluation of 1,4-phenylene-bis-pyrimidine-2-amine derivatives. Abstract: A series of 1,4-phenylene-bis-chalcones 3a–3h were synthesized by the reaction of terephthalaldehyde with substituted arylketones in this study. The novel 1,4-phenylene-bis-pyrimidine-2-amine derivatives 5a–5h were obtained by the addition of guanidine hydrochloride to 1,4-phenylene-bis-chalcone 3a–3h in ethanolic KOH under reflux conditions.. The anticancer activities of 3a–3h and 5a–5h were investigated against...