Có 20+ tài liệu thuộc chủ đề "hóa trị hệ thống"
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vascular endothelial growth factor receptor, 225. AJCC/UICC staging system, 74–75 choice of appropriate staging system,. CUPI staging system, 73–74 JIS staging system, 72–73 LCSGJ staging system, 72 Pathologist, 83–84. PDGFR, see Platelet derived growth factor receptor (PDGFR). Platelet derived growth factor receptor (PDGFR Pleomorphic HCCs, 40. Portal vein embolization (PVE) PVE, indications and contraindications. rate of liver regeneration, 155–156 technical...
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Hepatocellular Carcinoma. McMasters Jean-Nicolas Vauthey. McMasters, MD, PhD Department of Surgery University of Louisville Louisville, KY, USA [email protected]. Jean-Nicolas Vauthey, MD Department of Surgical Oncology University of Texas MD Anderson. Springer Science+Business Media, LLC 2011. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233...
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1 Epidemiology and Pathogenesis of Hepatocellular Carcinoma. 2 Biology of Hepatocellular Carcinoma. 5 Staging of Hepatocellular Carcinoma. of Hepatocellular Carcinoma in Japan. 8 Hepatocellular Carcinoma Arising in the Non-viral,. 9 Liver Resection for Hepatocellular Carcinoma. for Hepatocellular Carcinoma. of Hepatocellular Carcinoma: The American Perspective. 14 Liver Transplant for Hepatocellular Carcinoma. 15 Vascular Resection for Hepatocellular Carcinoma. 16 Radiofrequency Ablation for...
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is responsible for the first-pass metabolism of ethanol in the stomach, is signifi- cantly lower in women than in men, which implies that large amounts of alcohol will be metabolized by hepatic alcohol dehydrogenase [41, 42]. Despite this close relationship, there is little understanding of how HCV and alcohol may interact in the development of HCC. In most stud- ies,...
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Yeh FS, Yu MC, Mo CC, Luo S, Tong MJ, Henderson BE (1989) Hepatitis B virus, aflatox- ins, and hepatocellular carcinoma in southern Guangxi, China. Maheshwari S, Sarraj A, Kramer J, El-Serag HB (2007) Oral contraception and the risk of. hepatocellular carcinoma. De B, V, Welsh JA, Yu MC, Bennett WP (1996) p53 mutations in hepatocellular carcinoma related to oral...
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Thus, in the liver, differentiated hepatocytes per se can be viewed as the hepatic version of transit-amplifying cells. The fact that stem cell activation precedes the development of HCC in almost all models of hepatocarcinogenesis and invariably accompanies chronic liver damage in humans makes it likely that the mature hepatocyte is not the cell of origin of all HCCs [18]....
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While the incidence of HCCs has been rising worldwide, there has been a steady stream of novel information related to the histologic characteristics of HCCs, includ- ing their pattern of spread, the risk factors for recurrence, and long-term prognosis.. Understanding by histopathologists, surgeons, hepatologists, and oncologists of the nuances of the diagnosis of early HCC, as well as the importance...
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We will focus on only a few ancillary tests in the context of the usual clinical dilemmas.. Hepatocellular Carcinoma vs. detection tool, because of the abundance of the protein in the serum. In both instances, their detection offers evidence of hepatocellular differentiation [66, 67].. However, there is considerable overlap in the staining profiles of hepatocellular lesions (benign and malignant), and...
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Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide [1–5]. The majority of patients with HCC have a background of chronic liver dis- ease, especially chronic hepatitis due to hepatitis C virus (HCV) or hepatitis B virus (HBV) infection [6, 7]. Thus, at least some high-risk patients for HCC can be readily defined. Indeed, HCC surveillance is commonly...
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HCC is a suitable disease for surveillance programs because it is relatively common, at least in patients with liver disease.. Capocaccia R, Sant M, Berrino F, Simonetti A, Santi V, Trevisani F (2007) Hepatocellular carcinoma: trends of incidence and survival in Europe and the United States at the end of the 20th century. Kiyosawa K, Umemura T, Ichijo T, Matsumoto...
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UICC) 7th edition staging system [8]. T3b Single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein T4 Invasion of adjacent organs a or. For example, patients with N0M0 disease have 5-year survival of 64% with T1 F0 disease, 49% with T1 F1 disease, and 46% with T2 F0 disease [20].....
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Through technical improvements in both transplantation and resection, both fields continue to mature which contributes to the current lack of consensus. Adequate graft availability remains a practical constraint that also limits the availability of liver transplantation. Patients who have been treated for extrahepatic cancers are generally advised to successfully complete a disease-free surveillance period before undergoing liver transplantation for HCC,...
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7 Evidence-Based Guidelines for Treatment of Hepatocellular Carcinoma in Japan 95. Revisions of the Guidelines Based on the Latest Knowledge. There have been remarkable advances in the management of HCC recently, and the content of parts of the 2005 version of the guidelines, which was based on the literature as of 2002, has become outdated. The work of adding new...
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Patients with HH have a 20- to 200-fold increased risk of developing HCC [33–35]. Histologically, the overwhelming majority of these tumors are HCC and most occur in patients in their sixties. In a prospective longitudinal cohort study from Italy published in 2001, all cases of HCC in patients developed in those with cirrhotic livers [37]. However, there are approximately 10...
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The ratio of the CT measure FLR volume/calculated total liver volume (TLV) is defined as the standardized FLR and it provides the percent of TLV remaining after resection [30]. The formula used to estimate TLV based on BSA was recently evaluated in a meta-analysis and recom- mended as one of the least biased and most precise formulas for the estimation...
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et al. In a randomized controlled trial, El Moghazy et al. About 10–31% of the patients with intrahepatic recurrence can be treated with a second hepatectomy.. Bismuth et al. were the first to show that in the early era of liver transplantation, the surgical strategy for the treatment of hepatocellular carcinoma in cirrhosis had followed a misconception in selecting patients...
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Now, liver resections can be carried out with no mortality, even if cirrhosis is associated, combining the needs for oncological radicality and liver parenchyma sparing. Recently, the demonstration of the feasibility and efficacy of contrast-enhanced ultrasonography performed intraoperatively (CE- IOUS) has further stressed the relevance of IOUS guidance during liver surgery [7, 8]. For a proper IOUS, high-frequency echoprobes (7.5–10...
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this maneuver the flat and thin tip of the electrocautery is positioned between the probe and the liver surface: this maneuver results in a shadow at the IOUS image which runs deeply just below the electrocautery. In this way it is possible to define the position of the electrocautery with the tumor edge and consequently to mark with the electrocautery...
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Insulin is synergistic with HGF, resulting in slower regeneration rates seen in patients with diabetes [33, 34].. The extrahepatic factors are transported primarily from the gut to the liver via the portal vein and not from the hepatic artery and are directed . Shortly after the stimulus, hepatocytes leave the dormant stage of the cell cycle and undergo mitosis, with...
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11.4 Schematic representation shows modification of the ipsilateral technique for RPVE extended to segment 4. (a) Placement of a 6-French vascular sheath into the right portal branch. (c) After embolization of the right and seg- ment 4 portal veins are complete, the access tract is embolized with coils to prevent subcapsular hemorrhage. angled 5-French catheter into the portal vein branches...