Có 51+ tài liệu thuộc chủ đề "Phòng bệnh loãng xương"
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Effects of three resistance training programs on muscular strength and absolute and relative endurance. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin- sensitive pathway. The Journal of Nutrition . Altered responses in skeletal muscle protein turnover during aging in anabolic and catabolic periods.. The International Journal of Biochemistry &. American Journal of Physiology. Journal of...
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Potential ergogenic effects of arginine and creatine supplementation. Journal of Nutrition, 134(10 Suppl), S2888–2894S.. The New England Journal of Medicine . Journal of Electromyography and Kinesiology, 19, e290–e300.. Contraction-mediated mTOR, p70S6k, and ERK1/2 phosphorylation in aged skeletal muscle. Journal of Applied Physiology . American Journal of Physiology. Skeletal muscle mass and the reduction of VO2max in trained older subjects. Differential...
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Faulkner et al.. The explanation for the greater force during lengthening contractions than during isometric contractions is that during isometric contraction only the cross-bridges that are in their driving stroke generate tension, but when a maximally activated muscle is stretched, additional strongly-bound cross-bridges that have not progressed into their ‘driving stroke’ resist the ‘lengthening’ of the skeletal muscle, are strained...
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7 (a) Model of the sarcolemmal membrane skeleton and its relationship to desmin and cytokeratin. This figure depicts a model of the organization of the muscle cell surface, from the extracellular space to the contractile apparatus. The membrane skeletal and intermediate filament proteins that we have studied at costameres are emphasized, whereas many proteins known to be at or near...
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muscle expresses Class 1 isoforms (Shemer et al. Both sources of IGF-1 contribute to growth (see Section 2.2). A detailed critique of different genetically modified mouse models to investigate IGF-1 function lies beyond the scope of this Chapter but is reviewed elsewhere (Shavlakadze et al. Le Roith et al.. In skeletal muscle, the most abun- dant are IGFBP-3 and -5,...
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Vitamin D deficiency is extremely prevalent in the elderly and can result in myopathy with loss of muscle strength and selective loss of fast myofibres similar to sarcopenia (Janssen et al. Likewise, mutations that disrupt the GH/IGF-1 axis in mammals extend life-span despite causing dwarfism (Bartke et al. Klotho does not affect appetite and, therefore, the longevity of mice overexpressing...
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McMahon et al.. Tissue-specific transcription start site usage in the leader exons of the rat insulin-like growth factor-I gene: evidence for differential regulation in the developing kidney. Optimal protein intake in the elderly. Normal growth and development in the absence of hepatic insulin-like growth factor I. Low levels of myostatin expression are seen in heart, adipose tissue and mammary gland....
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Rebbapragada et al. TGF-b superfamily signalling is primarily mediated through substrates known as Smads (Piek et al. Smads 6 and 7) (Piek et al. Souchelnytskyi et al. Zhang et al.. Hayashi et al. Nakao et al. Consistent with other members of the TGF-b superfamily, myostatin has been shown to signal specifically through Smads 2/3 with the involvement of Smad 4...
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myostatin results in both enhanced body mass and skeletal muscle hypertrophy in the mdx mouse model of DMD (Bogdanovich et al. Bogdanovich et al. Consistent with antibody-mediated myostatin blockade, propeptide injection resulted in enhanced growth, increased muscle mass and grip strength (Bogdanovich et al. They further showed that this blockade resulted in enhanced muscle specific force, over and above that...
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McFarlane et al.. Transcriptional profiling of myostatin-knockout mice implicates Wnt signaling in postnatal skeletal muscle growth and hypertrophy. Regenerated mdx mouse skeletal muscle shows differen- tial mRNA expression. 447 Role of Myostatin in Skeletal Muscle Growth and Development. Inhibition of myostatin in adult mice increases skeletal muscle mass and strength. Fibroblast growth factor promotes recruit- ment of skeletal muscle satellite...
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of formoterol and revealed significant expression changes in genes associated with skeletal muscle hypertrophy, myoblast differentiation, metabolism, circadian rhythm, transcription, histones, and oxidative stress. With respect to formoterol’s anabolic effects, differentially expressed genes relevant to the regulation of muscle mass and metabolism were validated by quantitative RT-PCR to examine gene expression after acute (1–24 h) and chronic administration (1–28 days)...