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Critical Care Obstetrics part 36

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A number of human and animal studies have implicated the neutrophil as one of the key cellular mediators of this early phase of acute lung injury. Although plain chest radiographs in ALI/ARDS suggest a diffuse process, studies utilizing computed tomography of the chest (CT scans) have shown that in fact lung involvement in ALI and ARDS is inhomogeneous, with alveolar...

Critical Care Obstetrics part 37

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Table 25.1 Clinical setting of pulmonary edema in pregnancy.. Mechanisms of pulmonary edema clearance: from basic research to clinical implication. During pregnancy, the valvular heart disease which commonly results in pulmonary edema is rheumatic mitral stenosis.. These women are apt to go into pulmonary edema postpartum after autotransfusion from the contracting uterus. This autotransfusion is associated with an approximately 10...

Critical Care Obstetrics part 38

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The most common cause of the acute abdomen in pregnancy is appendicitis, which occurs with a rate of approximately 1 in 1500 deliveries [10,11. The diagnosis of appendicitis in pregnancy can be diffi cult to make because of the blunted signs and symptoms during pregnancy, along with the changing location of the appen- dix as pregnancy advances. Ultimately, as in...

Critical Care Obstetrics part 39

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The role of ultrasound is typically quite limited in the initial evaluation of patients who have pancreatitis, because the pan- creas often is obscured by bowel gas. Additionally, the pancreas may have an entirely normal sonographic appearance in the acute phase. Lipase levels were also studied, and no signifi cant difference was found between the second and third trimesters or...

Critical Care Obstetrics part 40

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Renal ultrasound is the fi rst step in the evaluation of possible urinary tract obstruction, although results may be inconclusive due to the physiologic dilation of the collecting system often seen in pregnancy due to both the effects of progesterone and the mechanical pressure of the gravid uterus. Relief of the obstruction may be accomplished by ureteral stent placement, percutaneous...

Critical Care Obstetrics part 41

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Acute fatty liver of pregnancy . Acute fatty liver in the second trimester . Acute fatty liver of pregnancy at 23 weeks of gestation . Recurrent acute fatty. liver of pregnancy . Recurrent acute fatty liver of. Idiopathic acute fatty liver of pregnancy in twelve patients . Acute fatty liver. Acute fatty liver of pregnancy and long - chain 3...

Critical Care Obstetrics part 42

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Sickle Cell Crisis. Guideline for the Management of Acute and Chronic Pain in Sickle Cell Disease . Patient - controlled analgesia for sickle - cell - related pain . Comparison of intramuscular analgesic activity of butorphanol and morphine in patients with sickle cell disease . Oxygen therapy in sickle cell disease . transfusions in pregnancies associated with sickle cell hemoglobin-...

Critical Care Obstetrics part 43

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One of the repeated CUB domains at the carboxyl - termi- nal end of each ADAMTS - 13 enzyme, as well as one or more of the thrombospondin - 1 - like domains along the length of the mol- ecule, may modulate the binding of ADAMTS - 13 to ULVWF multimers as they are secreted by endothelial cells [60 –...

Critical Care Obstetrics part 44

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Morphologic diagnosis of thrombotic thrombocytopenic purpura . thrombotic thrombocytopenic purpura . 23 Venat - Bouvet L , Ly K , Szelag JC , et al. Recent advances in thrombotic thrombocytopenic purpura . Pregnancy outcomes after recovery from thrombotic thrombocytopenic purpura - hemolytic uremic syndrome . 30 Martinez - Roman S , Gratacos E , Torn é A , et al....

Critical Care Obstetrics part 45

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Mitsuda et al. In four of the mothers, TBII levels were elevated. Mortimer et al. Similarly, Momotani et al. Wing et al. Similarly, Davis et al. This is consistent with a review of the literature by Mandel et al. The hemodynamic changes of hypothyroidism are summarized in the table. Leung et al. Pekonen et al. Kriplani et al. Although propylthiouracil...

Critical Care Obstetrics part 46

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One of the more striking clinical risk factors for the develop- ment of pre - eclampsia is the antiphospholipid syndrome. [44] studied 43 women who presented with severe pre - eclampsia prior to 34 weeks of gesta- tion and found 16% to have signifi cant levels of antiphospholipid antibodies. They recommended that women with early - onset severe pre -...

Critical Care Obstetrics part 47

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Schannwell et al. Desai et al. Diastolic dysfunction in patients with severe hypertension from pre - eclampsia needs to be recognized as a potential cause for fulminant pulmonary edema, cardiac failure and sudden death [204] It is important that the obstetrician understand that diastolic dysfunction can occur despite normal left ventricular systolic function, and in the face of an elevated...

Critical Care Obstetrics part 48

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Am J Obstet Gynecol 1990 . Preeclampsia associated with hemolysis, elevated liver enzymes, and low platelets: an obstetric emergency? Obstet Gynecol 1983 . Am J Obstet Gynecol 1984 . Obstet Gynecol 1989 . 65 Sibai BM , Saslimi M , Abdella TN , et al. Am J Obstet Gynecol 1985 . Am J Obstet Gynecol 1994 . Obstet Gynecol 1990...

Critical Care Obstetrics part 49

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Simple exposure of the maternal circula- tory system to even small amounts of amniotic fl uid or other fetal tissue may, under the right circumstances, initiate the syndrome of AFE. This understanding explains the well - documented occur- rence of fatal AFE during fi rst - trimester pregnancy termination at a time when neither the volume of fl uid nor...

Critical Care Obstetrics part 50

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Women with APS should be counseled about the potential risks of heparin therapy during pregnancy including heparin. Recommended in women with a history of thrombotic events Standard Heparin. 5 Prokunina L , Castillejo - Lopez C , Oberg F , et al. A regulatory poly- morphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans . 6...

Critical Care Obstetrics part 51

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Assessment of the patient with trauma in the fashion just described will immediately identify signifi cant cardiovascular or central nervous system dysfunction. The next step in the evalua- tion is to expose. Because of the potential for both fetal viability and the supine hypotension effects previously described, pregnancies greater than 20 – 24 weeks gestation evoke different management concerns than...

Critical Care Obstetrics part 52

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Unfortunately, reperfusion of the injured area may occur in the presence of absent or diminished autoregulation. In order to avoid or limit permanent cerebral injury, specifi c cerebral resuscitation must be carried out in the head trauma victim. With blunt head trauma, especially in deceleration events, move- ment of the brain occurs fi rst in one direction with a secondary...

Critical Care Obstetrics part 53

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Since different parts of the body provide varying degrees of resistance, the damage caused by electricity can vary. These changes can make the management of the burn patient especially challenging. Colloid osmotic pres- sure is decreased in the vascular spaces. A loss of integrity of the skin results in a loss of body water. This loss is more exaggerated in...

Critical Care Obstetrics part 54

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Figure 39.2 (a) Guidelines for evaluation and management of pregnant patients with a known or suspected toxic exposure. (b) Guidelines for the evaluation of the unconscious pregnant patient with a known or suspected toxic exposure. This represents 12% of the toxic exposures reported during pregnancy for that year and less than 1% of the suicide attempts by poisoning reported to...

Critical Care Obstetrics part 55

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Placental transfer of therapeutic levels of N - acetylcysteine has been docu- mented in humans and provides evidence of a direct antidotal effect of N - acetylcysteine in the fetus [46]. A level drawn less than 4 hours after ingestion may be falsely low resulting from a partial absorption.. Treatment should be administered if level is above solid line.. The...