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Clear cell renal cell carcinoma


Tìm thấy 11+ kết quả cho từ khóa "Clear cell renal cell carcinoma"

Identification of C3 and FN1 as potential biomarkers associated with progression and prognosis for clear cell renal cell carcinoma

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Liu S et al : miR-429- CRKL axis regulates clear cell renal cell carcinoma malignant progression through SOS1/MEK/ERK/MMP2/MMP9 pathway. https://doi.org/10.1016/j.biopha . Cheng R et al : miR-216b post-transcriptionally downregulates oncogene KRAS and inhibits cell proliferation and invasion in clear cell renal cell carcinoma. https://doi.org/10.3892/ijmm.2019.4328.. https://doi.org/10.1182/blood .

A novel ferroptosis-related gene signature associated with cell cycle for prognosis prediction in patients with clear cell renal cell carcinoma

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prediction in patients with clear cell renal cell carcinoma. Background: It is of great urgency to explore useful prognostic markers for patients with clear cell renal cell carci- noma (ccRCC). Prognostic models based on ferroptosis-related gene (FRG) in ccRCC is poorly reported for now.. We carried out least absolute shrinkage and selection operator analysis to screen out prognosis-related FRGs and constructed prognosis model for patients with ccRCC.

53 years old is a reasonable cut-off value to define young and old patients in clear cell renal cell carcinoma: A study based on TCGA and SEER database

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53 years old is a reasonable cut-off value to define young and old patients in clear cell renal cell carcinoma: a study based on. Background: The objectives of this study were to screen out cut-off age value and age-related differentially expressed genes (DEGs) in clear cell renal cell carcinoma (CCRCC) from Surveillance Epidemiology and End Results (SEER) database and The Cancer Genome Atlas (TCGA) database.. The age cut- off value was defined using the X-tile program.

Integrating HECW1 expression into the clinical indicators exhibits high accuracy in assessing the prognosis of patients with clear cell renal cell carcinoma

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Table 1 Demographics and characteristics of patients with clear cell renal cell carcinoma (ccRCC). Time- dependent receiver operating characteristic (ROC) analysis was performed using ‘survivalROC’ package to determine the optimal cut-off values of the H-scores of HECW1. HECW1 expression is decreased in clear cell renal cell carcinoma.

Identification of an independent immunegenes prognostic index for renal cell carcinoma

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Immune associated LncRNAs identify novel prognostic subtypes of renal clear cell carcinoma. https://doi.org/10.1 002/mc.22949.. Comprehensive characterization of immune- and inflammation-associated biomarkers based on multi-omics integration in kidney renal clear cell carcinoma. https://doi.org/10.1186/s y.. characterization of clear cell renal cell carcinoma. https://doi.org/10.1038/nature12222.

Effect of spectral CT on tumor microvascular angiogenesis in renal cell carcinoma

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FORCE dual-energy CT in pathological grading of clear cell renal cell carcinoma. https://doi.org/10.3892/ol . Papillary vs clear cell renal cell carcinoma. https://doi.org/10.1007/s . https://doi.org/10.1186/s x.. Characterization of clear cell renal cell carcinoma and other renal tumors:. Normalized dual-energy iodine ratio best differentiates renal cell carcinoma subtypes among quantitative imaging biomarkers from perfusion CT and dual-energy CT. https://doi.org/10.2214/AJR.19.22612..

Genome instability-related long non-coding RNA in clear renal cell carcinoma determined using computational biology

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Results: In the present study, we applied computational biology to identify genome-related long noncoding RNA and identified 26 novel genomic instability-associated lncRNAs in clear cell renal cell carcinoma. To further elucidate the role of the six lncRNAs in the model ’ s genome stability, we performed a gene set variation analysis (GSVA) on the matrix.

Up-regulation expression and prognostic significance of Syntaxin4 in kidney renal clear cell carcinoma

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KIRC: Kidney renal clear cell carcinoma. EAU guidelines on renal cell carcinoma: 2014 update. https://doi.org/10.1016/j.eururo . https://doi.org/10.3322/caac.21551.. Renal cell carcinoma: diagnosis and management.

A novel ferroptosis-related 12-gene signature predicts clinical prognosis and reveals immune relevancy in clear cell renal cell carcinoma

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In the KIRC cohort, we found that 9 out of 16 immune cells had significantly higher infiltration enrichment scores in the high-risk group: CD8+ T cells, macro- phages, plasmacytoid dendritic cells (pDCs), T helper cells, follicular helper T cell (Tfh), helper T cells 1 (Th1 cells), helper T cells 2 (Th2 cells), tumour infiltrating lymphocyte (TIL) and regulatory T cell (Treg), while im- mature dendritic cells (iDCs) and mast cells showed the opposite pattern (Fig.

Molecular identification of an immunityand Ferroptosis-related gene signature in non-small cell lung Cancer

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A new survival model based on ferroptosis-related genes for prognostic prediction in clear cell renal cell carcinoma. https://doi.org/10.1 8632/aging.103553.. https://doi.org/10.12659/MSM.921947.. https://doi.org/10.1016/j.. https://doi.org/10.1093/carcin/bgaa090.. https://doi.org/10.1530/. doi.org/10.7554/eLife.02523.. https://doi.org/10.1016/j.cmet . org/10.1038/ncb3064.. https://doi.org/10.1073/pnas . org/10.1111/cas.14869.. org/10.3324/haematol . https://doi.org . doi.org/10.1182/blood.v99.5.1505

Bioinformatics analysis of C3 and CXCR4 demonstrates their potential as prognostic biomarkers in clear cell renal cell carcinoma (ccRCC)

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GO:0007162 ~ negative regulation of cell adhesion. GO:0015696 ~ ammonium transport RHCG, RHBG GO:0006873 ~ cellular ion homeostasis RHCG, SLC4A1 GO:0019740 ~ nitrogen utilization RHCG, RHBG GO:0010543 ~ regulation of platelet activation FCER1G, HRG GO:0051005 ~ negative regulation of. GO:0034123 ~ positive regulation of toll-like re- ceptor signaling pathway. GO:0050776 ~ regulation of immune response C3, ITGB2, FCGR3A, TREM2, TYROBP GO:0030514 ~ negative regulation of BMP.

Chapter 090. Bladder and Renal Cell Carcinomas (Part 5)

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Bladder and Renal Cell Carcinomas. Renal Cell Carcinoma. Renal cell carcinomas account for 90–95% of malignant neoplasms arising from the kidney. Notable features include resistance to cytotoxic agents, infrequent responses to biologic response modifiers such as interleukin (IL) 2, and a variable clinical course for patients with metastatic disease, including anecdotal reports of spontaneous regression..

Outcomes of renal cell carcinoma with associated venous tumor thrombus: Experience from a large cohort and short time span in a single center

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Clear-cell carcinoma . Non-clear cell carcinoma . were 59 and 47%, while it was 48 and 32% for the patients with high VTT level. In terms of independent prognostic factors for patients with RCC with VTT, 5 candidate risk factors were statis- tically significant in univariable Cox regression model analysis, and the 5 factors were affirmed in Kaplan–.

Clinicopathologic features of TDO2 overexpression in renal cell carcinoma

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Clinicopathologic features of TDO2 overexpression in renal cell carcinoma. Several lines of evidence revealed that overexpression of TDO2 is involved in anoikis resistance, spheroid formation, proliferation, and invasion and correlates with poor prognosis in some cancers. The aim of this research was to uncover the expression and biofunction of TDO2 in renal cell carcinoma (RCC)..

Chapter 090. Bladder and Renal Cell Carcinomas (Part 7)

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Bladder and Renal Cell Carcinomas. Renal Cell Carcinoma: Treatment. The prognosis of metastatic renal cell carcinoma is variable. Cohen HT, McGovern FJ: Renal-cell carcinoma. Motzer RJ et al: Sunitinib in patients with metastatic renal cell carcinoma.. Nelson EC et al: Renal cell carcinoma: Current status and emerging therapies. Winquist E et al: Neoadjuvant chemotherapy for transitional cell carcinoma of the bladder: A systematic review and meta-analysis

The prognostic value of circulating tumour cells (CTCs) and CTC white blood cell clusters in patients with renal cell carcinoma

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Keywords: Renal cell carcinoma, CTC-WBC cluster, Circulating tumour cells, Metastasis-free survival, Prognosis. Full list of author information is available at the end of the article. Renal cell carcinoma (RCC) is a common tumour of the urinary system, accounting for 80 to 85% of all kidney tumours and 3.8% of all newly diagnosed tumours [1].. In RCC, the prognostic value of CTC-WBC clusters is not clear.

Overexpression of PFKFB3 promotes cell glycolysis and proliferation in renal cell carcinoma

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However, the specific function and clinical significance of PFKFB3 in renal cell carcinoma (RCC) are yet not clarified. This investigation assessed PFKFB3 roles in RCC.. Furthermore, a murine xeno- graft model was employed for investigating the effect of PFKFB3 on tumor growth in vivo.. Results: PFKFB3 was significantly up-regulated in RCC specimens and cell lines in comparison to normal control..

Fibrinogen/albumin ratio as a promising predictor of platinum response and survival in ovarian clear cell carcinoma

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OCCC : Ovarian clear cell carcinoma. Fibrinogen/albumin ratio. The funding bodies didn’t participate in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.. Epithelial ovarian cancer: evolu- tion of management in the era of precision medicine. Clear cell carcinoma of the ovary: a review of the literature. Clear cell car- cinoma of the ovary: a report from the first ovarian clear cell symposium, June 24th, 2010.

Serum and urine analysis with gold nanoparticle-assisted laser desorption/ionization mass spectrometry for renal cell carcinoma metabolic biomarkers discovery

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ionization mass spectrometry for renal cell carcinoma metabolic biomarkers discovery. Gold nanoparticles Kidney cancer biomarkers Laser desorption/ionization Mass spectrometry Renal cell carcinoma. Purpose: Renal cell carcinoma (RCC) is a very aggressive and often fatal heterogeneous disease that is usually asymptomatic until late in the disease.

Chapter 090. Bladder and Renal Cell Carcinomas (Part 6)

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The differential diagnosis of a renal mass includes cysts, benign neoplasms (adenoma, angiomyolipoma, oncocytoma), inflammatory lesions (pyelonephritis or abscesses), and other primary or metastatic cancers. Other malignancies that may involve the kidney include transitional cell carcinoma of the renal pelvis, sarcoma, lymphoma, and Wilms' tumor. All of these are less common causes of renal masses than is renal cell cancer..