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Epigenetic modification

Tìm thấy 17+ kết quả cho từ khóa "Epigenetic modification"

Physical activity in the prevention of human diseases: Role of epigenetic modifications

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Physical activity in the prevention of human diseases: role of epigenetic modifications. Epigenetic modification refers to heritable changes in gene function that cannot be explained by alterations in the DNA sequence.

Identification, expression, and artificial selection of silkworm epigenetic modification enzymes

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Meanwhile, epigenetic modifications were also determined to be involved in the regulation of domesticated phenotypes [6]. The composition and function of the DNMT toolkit in insects also differ from those of mammals [7]. Kucharski et al. For example, CBP-mediated histone acetylation in the ant central brain can regulate caste-specific foraging and scouting behaviors [10].

Genome-wide analysis of epigenetic dynamics across human developmental stages and tissues

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The value in row i column j represents the proportion of HDMSs of epigenetic modification i overlapped by those of epigenetic modification j. 3 The heatmaps representing the correlations between each pair of epigenetic modifications. of epigenetic modification patterns and gene expression within HDMSs may provide important insights into the regulatory functions of the specific epigenetic patterns.. Highly dynamic modified sites neighboring genes reveal diverse transcriptional patterns.

ICGEC: A comparative method for measuring epigenetic conservation of genes via the integrated signal from multiple histone modifications between cell types

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Usually, one would estimate the similarities of different genes in terms of their epigenetic circumstances between two conditions with the Pearson correlation coefficients of the pairwise vectors of epigenetic modification levels..

Genome-wide DNA methylation profiling reveals novel epigenetic signatures in squamous cell lung cancer

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Tumorigenesis involves a multi-step process, which is the result of the interactions of genetic, epigenetic and environmental factors. DNA methylation is a major epigenetic modification which leads to gene. Full list of author information is available at the end of the article. 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0.

Selective modulation of local linkages between active transcription and oxidative demethylation activity shapes cardiomyocyte-specific gene-body epigenetic status in mice

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Curiously, ECM expan- sion in Smyd1-deficient mice may be mediated by the regulation of the translation process, as it does not involve the transcriptional activation of related genes [36], directing our attention to the link be- tween gene body epigenetic modification and transla- tion regulation.. We found that high levels of gene- body Pol II or p300 accumulation are associated with cell-type-specific hypomethylated regions present in an extreme gene population of CMs.

Reprogramming histone modification patterns to coordinate gene expression in early zebrafish embryos

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Reprogramming histone modification. Background: Multicellular organisms require precise gene regulation during ontogeny, and epigenetic modifications, such as DNA methylation and histone modification, facilitate this precise regulation. The conservative reprogramming patterns of DNA methylation in vertebrates have been well described.

Genome-wide epigenetic variation among ash trees differing in susceptibility to a fungal disease

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Epigenetic regulation of the sex determination gene MeGI in polyploid Persimmon. Repetitive sequences and epigenetic modification: inseparable partners play important roles in the evolution of plant sex chromosomes. Genetic and epigenetic reprogramming of the wheat genome upon allopolyploidization. Spontaneous epigenetic variation in the Arabidopsis thaliana methylome.. Highly integrated single-base resolution maps of the epigenome in Arabidopsis.

A comprehensive epigenomic analysis of phenotypically distinguishable, genetically identical female and male Daphnia pulex

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The effect of the histone modifications on gene expression level was clear and in line with the expectations (Fig. 6) with H3K4me3 modification promoting higher expression level and H3K27me3 modification generally suppressing the expression of the genes. 8 a) Density plot of the epigenetic modification. 50%) in both genders demonstrated an elevated expression level compared to rest of the genes (Fig. 7a, genes with both modifications had a significantly higher expression level compared to the rest

Integrated analysis of the methylome and transcriptome of chickens with fatty liver hemorrhagic syndrome

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In particular, DNA methylation, an important epigenetic modification, has been closely associated with hepatic lipogenesis and fatty liver [12, 13]. Previous reports have demonstrated lipid metabolism to be up-regulated with differential gene methylation in in- dividuals with fatty liver disease [15]. Liu et al. Sookoian et al. demonstrated hyper methylation of PPARγ in fatty liver subjects [17].. In previous study, Zhang et al.

Genome-wide DNA methylation analysis of Metarhizium anisopliae during tick mimicked infection condition

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Moreover, the importance of the DNA methylation on cell morphogenesis is further supported by the GO analysis, reiteratively demonstrating the im- portance of this epigenetic modification in the lifecycle and infection of M. in the infection process, the expression of virulence determinants can be crucial even when the virulence determinants are potentially. In the absence of host’s stimuli, the energetic expenditure should be real- located.

Paramutation-like features of multiple natural epialleles in tomato

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It is unlike other epigenetic mechanisms, however, in that it involves transfer of the silent state from an allele with epigenetic modification to its active homologue. RdDM is also associated with paramutation of the SULFUREA locus in tomato [10, 11] and trans- chromosomal DNA methylation in Arabidopsis thaliana hybrids [12, 13]. Based on these findings the dominant model of paramutation implicates RdDM in the establish- ment and/or maintenance of the epigenetic mark..

DNA methylation profiles correlated to striped bass sperm fertility

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DNA methylation is one of the most common epigenetic modification types and changes in sperm epigenetics can be correlated to sub-fertility or infertility in male striped bass. Results: In our present study, we performed DNA methylation analysis of high-fertility and sub-fertility striped bass spermatozoa through MBD-Seq methods. A total of 171 DMRs were discovered in striped bass sperm correlated to fertility.

MethGET: Web-based bioinformatics software for correlating genome-wide DNA methylation and gene expression

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Background: DNA methylation is a major epigenetic modification involved in regulating gene expression. The effects of DNA methylation on gene expression differ by genomic location and vary across kingdoms, species and environmental conditions. To identify the functional regulatory roles of DNA methylation, the correlation between DNA methylation changes and alterations in gene expression is crucial.

Chromatin states responsible for the regulation of differentially expressed genes under 60Co~γ ray radiation in rice

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Antagonistic roles for H3K36me3 and H3K27me3 in the cold-induced epigenetic switch at Arabidopsis FLC. Epigenetic modification of centromeric chromatin: hypomethylation of DNA sequences in the CENH3-associated chromatin in Arabidopsis Thaliana and maize. High-resolution mapping of open chromatin in the rice genome

Accurate prediction of DNA N4-methylcytosine sites via boost-learning various types of sequence features

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Background: DNA N4-methylcytosine (4mC) is a critical epigenetic modification and has various roles in the restriction-modification system. However, state-of-the-art methods have limited performance because of the lack of effective sequence features and the ad hoc choice of learning algorithms to cope with this problem. This paper is aimed to propose new sequence feature space and a machine learning algorithm with feature selection scheme to address the problem..

Multiple omics analysis reveals that high fiber diets promote gluconeogenesis and inhibit glycolysis in muscle

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These pathways were classified into 22 clusters involved in several functions, such as epigenetic modification, muscle cell development, muscle fiber assembly, regu- lation of the glucose metabolic process, RNA trans- port, and the steroid hormone mediated signalling pathway (Fig.

Comparative transcriptome analysis reveals ecological adaption of cold tolerance in northward invasion of Alternanthera philoxeroides

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Epigenetic modification of the transcription factor genes in A. Contig12_All) which increased prom- inently in the JN population compared to the HK popu- lation under cold stress, for epigenetic analysis. We first examined the full-length coding region of these genes in the JN and HK populations separately. H3K4me3), which are known as activating epigenetic marks, in the promoter region [21–23].

Histone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes

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Conclusions: Together, these datasets provide a comprehensive resource for histone modification profiles that define epigenetic landscapes and reveal key chromatin signatures in breast cancer cell line subtypes with potential to identify novel and actionable targets for treatment.. Keywords: Breast cancer subtypes, Epigenetics, Histone modifications, Chromatin states.

Key actors in cancer therapy: Epigenetic modifiers

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Therefore, new therapy regimes which include epigenetic modifiers have begun assessment in clinical trials (Samavat et al., 2016. Azad et al., 2017. Von Hoff et al., 2018). Kagara et al., 2012;. Vedeld et al., 2014). the epigenetic modifiers (Fraga et al., 2005). Matei et al., 2012. There are also several preclinical studies that have shown promising results in targeting CSCs via these drugs (Tian et al., 2012. Liu et al., 2015. Jiang et al., 2018).. Cui et al., 2017. Zhao et al., 2017).