Tìm thấy 15+ kết quả cho từ khóa "Local anaesthetics"
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Altogether, three of four tested local anes- thetics up to 2.5 mM did not induce apoptosis in esophageal carcinoma cells.. The differential combinatory effects of local anaesthetics with chemotherapy drugs on esophageal carcinoma cell migration, growth and survival. To investigate whether local anaesthetics influence the efficacy of chemotherapy in esophageal carcinoma cells, we performed combination studies using local anaesthetics and commonly used chemotherapeutic drugs: 5-FU and paclitaxel.
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II.4.8 Local anaesthetics. Local anaesthetics reversibly block neural transmission in local tissues. Local anaesthetics can be classifi ed into ester-type and amide-type drugs according to their structures. Both types of the drugs diff er in the mode of metabolism and chemical stability. Th e ester-type local anaesthetics are easily hydrolyzed by the action of pseudocholinesterase in blood plasma, and are also rapidly decomposed in alkaline solutions nonenzymatically.
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Keywords: Procaine, Rats, Knee joint, Intra-articular injections, Local anaesthetics. Intra-articular local anaesthetics are widely used for pro- viding postoperative analgesia and decreasing the need for opioids and side effects related to their usage. However, recent in vitro and in vivo studies showed chondrotoxic effects of some widely used intra-articular local anaes- thetics, especially bupivacaine and lidocaine [1 – 3]..
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The latter had long been interested in the problem of local anaesthesia in the eye, for general anaesthesia has disadvantages in ophthalmology. Observing that numbness of the mouth occurred after taking cocaine orally he realised that this was a local anaesthetic effect. Local anaesthetics prevent the initiation and propagation of the nerve impulse (action potential). Paradoxi- cally the effect in the central nervous system is stimulation (see below)..
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The differential effects of three local anesthetics at concentration range from 0.25 to 2 mM on melanoma cell proliferation (c) and survival (d). and inducing apoptosis in melanoma cells (Fig. The combinatory effects of local anaesthetics with vemurafenib or dacarbazine are likely to be synergistic. We did not observe further inhib- ition of the combination of bupivacaine with vemurafenib or dacarbazine in melanoma cells (Fig.
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Nonopioid additives to local anaesthetics for caudal blockade in children: a systematic review.. Minimum local analgesic concentration of ropivacaine for intra-operative caudal analgesia in pre- school and school age children. Relative analgesic potencies of levobupivacaine and ropivacaine for caudal anesthesia in children. Effect of epidural clonidine on minimum local anesthetic concentration (ED50) of levobupivacaine for caudal block in children.
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The closer the nerve damage is to the injected local anaesthetics and steroids, the more beneficial the effect of both the anaesthetics and steroids [7].. Paravertebral block decreases postoperative pain and re- duces opioid consumption, in turn improving postoperative pulmonary function and potentially enabling early extuba- tion [8].
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Lastly, the temporal offset between applications of local anaesthetics (preoperativ US-ILIHB. postoperativ PWI) could influence pain assessment due to the different residence times of local anaesthetics. However, a clear difference between pre- operative or postoperative block in terms of the reduc- tion of pain has not been demonstrated so far [25, 26].. rel.freq.: Relative frequency of occurence of pain;.
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Although the LM group also received morphine in local anaesthetics, the absorption of morphine was slow, and the blood concen- tration of morphine was lower than that in the other two groups. Therefore, morphine had reduced side ef- fects in the LM group. In addition, the inhibition of PONV in the LM group was also attributed to the im- provement in postoperative bowel recovery..
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Amiodarone adverse effects, 503 atrial fibrillation, 508 interactions, 503-4 pharmacokinetics, 503 Amitriptyline. adverse effects, 219-20. chemoprophylaxis, 243 local anaesthetics adrenaline with, 359, 452 adverse effects, 360 as antitussives, 550 desired properties, 358 essential (WHO list), 28 mode of action, 358 peri-/postoperative use, 347 pharmacokinetics, 358 topical effect Anagrelide, 600. adrenal, suppressing secretion, 672 adverse effects, 714. anabolic effects, 713, 715 see also Anabolic
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Patients were excluded if they had any medical condi- tions considered to affect patient safety or the quality of the study, or if they had any known hypersensitivity to local anaesthetics of amide type or any of the other con- tents in the substance used.
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Jorgensen, H., et al., Epidural local anaesthetics versus opioid-based analgesic regimens on postoperative gastrointestinal paralysis, PONV and pain after abdominal surgery The Cochrane database of systematic reviews, 2000(4): p. Ballantyne JC, et al. Popping, D.M., et al., Protective effects of epidural analgesia on pulmonary complications after abdominal and thoracic surgery: a meta-analysis.
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It might be expected that Dex potentiates the spinal block via a synergistic interaction between α2-AR antagonists and sodium channels, resulting in a reduction in the dose of the local anaesthetics required for achieving effective spinal anaesthesia for certain surgical procedures.. 3 Dose-response curve of intrathecal hyperbaric bupivacaine in the two groups. Table 2 Characteristics of spinal anaesthesia in patients with effective anaesthesia. Dex group ( n = 36).
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Third, dif- ferent doses and concentrations of local anaesthetics had been used in the studies, and corresponding drugs such as paracetamol and dexamethasone had also been used after surgery. Although these postoperative drugs had been used in both groups, the usage of these drugs in- creases the complexity of the present study. In addition, the incidence of itching was comparable between the groups, whereas the incidence of PONV was reported to be higher in the ITM group.
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Thoracic paravertebral block (TPVB) is a technique in which local anaesthetics are injected into the thoracic paravertebral space (PVS), which is lateral to the inter- vertebral foramina, resulting in ipsilateral somatic and sympathetic nerve blockade that spreads from the site of injection across multiple contiguous dermatomes. Some reports have indicated high success rates and very few complications associated with an in-plane transverse ultrasound-guided TPVB approach [1].
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Local anaesthetics have an important role in post-op- erative analgesia, and they might have a role in the pre- vention of persistent pain after caesarean section [13, 14]..
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Local anaesthetics do not offer any long-term solution and since they are liable to sensitise the skin they are best avoided. Penetration into the skin is governed by the factors outlined at the beginning of this chapter.. Advise the patient to apply the formulation very thinly, just enough to make the skin surface shine slightly.. 5 The distance from the tip of the adult index finger to the first crease..
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Chính vì thế người quản trị mạng sẽ sử dụng công cụ Local Users and Groups để tạo các tài khoản người dùng trên cùng một máy, khi đó dữ liệu của người này người kia không thể truy cập được.. Local User - Để tạo được User local bạn phải có quyền ngang hang với Administrator của hệ thống.. Local User and group ->. Right click vào Users chọn New Users. Hộp thoại New users xuất hiện.. Ở đây mình sẽ tạo hai users là gccom1 và gccom2. Tương tự như vậy với user gccom2..