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Neurodegenerative diseases

Tìm thấy 20+ kết quả cho từ khóa "Neurodegenerative diseases"

Physical activity in the prevention of human diseases: Role of epigenetic modifications

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The aims of this review is to analyse specifically the most significant findings in human beings highlighting the role of epigenetic mechanisms in the beneficial effects of physical activity (PA) towards the prevention or therapy of diseases such as cancer, metabolic, cardio- vascular and neurodegenerative diseases.

Neurochemical Mechanisms in Disease P7

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Animal Models of Neurodegenerative Diseases. Abstract The use of animals as models of neurodegenerative disorders has allowed the determination of biological targets and biomarkers of several diseases, has yielded new therapeutical perspectives, and is essential before performing novel clinical assays.

Identification of differentially expressed microRNAs in primary esophageal achalasia by next-generation sequencing

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The upregulation of miR-143 in the CD4+T cells, highlights the importance of this miRNA in autoimmune diseases (Martínez-Ramos et al., 2014). Some studies showed that PTEN has a direct role in neurodegeneration under oxidative stress conditions (Li et al., 2013b. Morris et al., 2010). SIRT1 levels are associated with neurodegenerative diseases which have a progressive and severe reduction in neuronal cells (Kim et al., 2007).

Compensatory expression regulation of highly homologous proteins HNRNPA1 and HNRNPA2

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In addition, HNRNPA1 and HNRNPA2 play an important role in RNA metabolism, which is consistently dysregulated in neurodegenerative diseases. Indeed, changes of HNRNPA1 and HNRNPA2 expression can improve the condition of patients with amyotrophic lateral sclerosis, spinal muscular atrophy, Alzheimer’s disease, and other neurodegenerative diseases (Bekenstein and Soreq, 2013).

The protective effect of N-acetylcysteine amide against paraquat-induced neurotoxicity

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Free radicals are reported to play a key role in the progression of neurodegenerative disorders. It was also shown that neuronal damage was increased by PQ with the activation of glial cells. 11,13 Since ROS stimulates neuronal death through multifactorial actions 13 , antioxidant supplementation is very valuable in the treatment of neurodegenerative diseases.. In the PQ group, SOD activity was significantly increased (P <. 0.05) when compared to the control group.

Chapter 024. Gait and Balance Disorders (Part 1)

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Older patients with mental status abnormalities and dementia from neurodegenerative diseases appear to be particularly prone to falls and injury.. Frailty, muscle weakness, and deconditioning undoubtedly contribute to the risk.. There is a growing literature on the use of attentional resources to manage locomotion.. The ability to walk while attending to a cognitive task (dual tasking) may be particularly compromised in older adults with a history of falls.

Neurochemical Mechanisms in Disease P68

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The clinical observation that many of these diseases affect supranuclear control of gaze further suggests that these diseases, all of which involve tau protein deposition, share similarities in their topographic pathology.. Table 3 Tau Neurodegenerative Diseases Classified by the Isoform of Tau Expressed. Familial Alzheimer’s disease Frontotemporal dementia.

Corn dried distillers grains with solubles (cDDGS) in the diet of pigs change the expression of adipose genes that are potential therapeutic targets in metabolic and cardiovascular diseases

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Currently, obesity, cardiovascular and neurodegenerative diseases are some of the main causes of death in highly developed countries. The results of our research show that the addition of cDDGS to the diet causes a reduction in the expression of genes involved in lipogenesis and cel- lular respiratory processes while stimulating the genes of the immune system.

Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine

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Association of heat-shock proteins in various neurodegenerative disorders: is it a master key to open the therapeutic door? Mol Cell Biochem. Heat shock proteins in neurodegenerative diseases: pathogenic roles and therapeutic implications. The Plasmodium falciparum Hsp70- x chaperone assists the heat stress response of the malaria parasite. A chemical inhibitor of heat shock protein 78 (HSP78) from Leishmania donovani represents a potential antileishmanial drug candidate.

Transcriptome analysis provides genome annotation and expression profiles in the central nervous system of Lymnaea stagnalis at different ages

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Aging and disease- relevant gene products in the neuronal transcriptome of the great pond snail (Lymnaea stagnalis): a potential model of aging, age-related memory loss, and neurodegenerative diseases. https://doi.org/10.1016/j.cell .

Association of cerebrovascular dysfunction with the development of Alzheimer’s disease-like pathology in OXYS rats

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In contrast, the imbalance of inflammatory responses in the central nervous system may serve as an initiating factor in many neurodegenerative diseases, including AD [19].. The main aim of this study was to identify the meta- bolic processes and pathways involved in the develop- ment of cerebrovascular dysfunction in OXYS rats.

Contribution of ginsenosides Rg1, Rb1 to the neuroprotective effect of Panax notoginseng in mouse organotypic hippocampal slice cultures exposed to oxygen and glucose deprivation

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Because of the important in vivo-like organization of nervous tissues in organotypic hippocampal slice cultures (OHSCs), they are commonly used as a model for screening neuroprotective agents for many neurodegenerative diseases and ischemia [8]. Thus, oxygen-glucose deprivation (OGD) in OHSCs are widely used as an in vitro model of ischemia to evaluate the neuroprotective effects of potential drugs..

Bis(indoline-2,3-diones): versatile precursors for novel bis(spirooxindoles) incorporating 4H-chromene-3-carbonitrile and pyrano[2,3-d]pyrimidine-6-carbonitrile derivatives

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Moreover, C – C bond formation via the Michael addition reactions of cinnamonitriles with compounds containing active methylenes is an interesting route for the synthesis of chromene and fused chromene derivatives. 17 Some chromene derivatives were used in the treatment of neurodegenerative diseases. 18 2-Amino-4 H -chromene derivatives bearing nitrile functionality also have numerous applications in the treatment of human inflammatory diseases, such as psoriatic and rheumatoid arthritis.

Neurochemical Mechanisms in Disease P34

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Both the normal size of the amino acid repeat and the pathologi- cal length of the repeat tend to be smaller in the A n -expansion diseases than in the Q n -expansion diseases. Although many of the trinucleotide-expansion diseases are rare (some exceedingly rare), they offer insights into pathophysiological processes that may pertain to the more common neurodegenerative diseases such as Alzheimer disease (AD) and Parkinson disease (PD)..

Neurochemical Mechanisms in Disease P37

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Beginning in the early 1990s, the genetic basis of a large number of inherited neurodegenerative diseases began to be elucidated. Many of the inherited neurode- generative diseases were found to be caused by trinucleotide expansions either in a noncoding region of the affected gene or in a coding region (Q n -expansion diseases;. A n -expansion diseases).

Combined ligand and structure-based virtual screening approaches for identification of novel AChE inhibitors

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Indole derivatives were considered in the therapeutic solutions of many different biological problems including cancer, migraine, hypertension and some neurodegenerative diseases. Thus, aim of the study is to find novel hit compounds against AChE using rigorous virtual screening approaches. The aim of this study is to perform a virtual screening of the National Cancer Institute (NCI) database [27].

Crosstalk between autophagy and DNA repair systems

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Abnormalities in the autophagic activity were associated with various diseases, including neurodegenerative diseases and cancer (Gozuacik et al., 2017. Bayraktar et al., 2016. Unal et al., 2020). Phosphorylation free TFE/MITF transcription factors translocate to the nucleus where they control both the transcription of autophagy and lysosome biogenesis genes (Settembre et al., 2013. Ozturk et al., 2019)..

GC-MS analysis of the methanolic extracts of Smilax china and Salix alba and their antioxidant activity

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Natural products and their active principles used in the treatment of neurodegenerative diseases: a review

Các hợp chất phenolic và lợi ích cho sức khỏe con người

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However, low-grade chronic inflammation is considered a critical factor in many diseases including cancers, obesity, type II diabetes, cardiovascular diseases, neurodegenerative diseases, and premature aging (Santangelo et al., 2007).. the arachidonic acid pathway, (ii) modulation of the nitric oxide synthetase family, and (iii) modulation of the cytokine system as well as of the nuclear factor kappa B (NF-kB) and mitogen-activated protein kinase (MAPK) pathways (Figure 4) (Santangelo et al., 2007

Neurochemical Mechanisms in Disease P65

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Perry G, Taddeo MA, Nunomura A, Zhu X, Zenteno-Savin T, Drew KL, Shimohama S, Avila J, Castellani RJ, Smith MA (2002) Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response. Pope S, Land JM, Heales SJ (2008) Oxidative stress and mitochondrial dysfunction in neurode- generation.