Có 16+ tài liệu thuộc chủ đề "Alzheimer's disease"
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To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.. 1 Alzheimer ’ s Disease Genetics Laboratory, School of Biological Sciences, University of Adelaide, North Terrace, Adelaide, SA 5005, Australia Full list of author...
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We studied the reliability, consistency and functional associations of co-splicing correlations of genes of interest, across two independent studies, multiple tissues and two statistical methods. We thoroughly investigated the reproducibility of co-splicing correlations of APP, the candidate gene of Azheimer ’ s disease (AD). Results: We replicated co-splicing correlations between APP and 5 AD-related genes and reproduced expected enrichment of...
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Furthermore, additional network structures suggest previously unreported regulations in the state of the art of Alzheimer’s research. The quantitative performance as well as sound biological findings provide confidence in the ensemble approach and encourage similar integrative analyses for other conditions.. MicroRNAs (miRNAs) are small noncoding RNA sequences that intervene in the regulation of protein- coding genes after transcription. MiRNAs bind...
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disease-like pathology in OXYS rats. Background: Cerebrovascular dysfunction plays a critical role in the pathogenesis of Alzheimer ’ s disease (AD): the most common cause of dementia in the elderly. The involvement of neurovasculature disorders in the progression of AD is now increasingly appreciated, but whether they represent initial factors or late-stage pathological changes during the disease is unclear. At...
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Liu et al., 2016).. recruit other immune cells to the infection site in order to eliminate the trigger and reestablish tissue homeostasis (He et al., 2015. Jorgensen et al., 2016).. the NFκB pathway or type I IFN pathway, in the case of endosomal TLRs (Bauernfeind et al., 2009). Muñoz-Planillo et al., 2013). Iyer et al.,. Although the activation of the...
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doi:10.3906/kim-1903-74 h t t p. Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders and causes of dementia in Western society, mostly affecting the elderly population. The most prominent symptom of this disease is a progressive decrease in cognitive function, which in turn leads to changes in behavioral patterns and a decrease in the functional capacity of the...
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Food and Drug Administration (FDA) approved drugs donepezil, rivastigmine, tacrine and galantamine are AChE inhibitors and in the treatment of Alzheimer’s disease (AD) these drugs are currently prescribed. In the present study, we developed a computational pipeline method to predict the binding affinities of the studied compounds at the specific target sites.. Key words: Binary QSAR modeling, Alzheimer’s disease, virtual...
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doi:10.3906/kim-2004-36 h t t p. Synthesis and bioactivities of 1-(4-hydroxyphenyl)-2-((heteroaryl)thio)ethanones as carbonic anhydrase I, II and acetylcholinesterase inhibitors. The compounds 2 and 4 were found potent AChE inhibitors with the Ki values of nM and nM, respectively, while the compounds 2 (Ki nM, on hCA I) and 1 (Ki nM, on hCA II) had considerable CAs inhibitory potency. Also, the...
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doi:10.3906/kim-2007-37. One of the diseases that affects elderly people is Alzheimer’s disease (AD) which is a neurodegenerative disease that causes progressive dementia [5,6]. Some of the pathologies of AD are the loss of cholinergic neurons and a decreasing amount of neurotransmitter acetylcholine (ACh) in synapses. AChE inhibitors are the most used medication in the treatment of AD which act as...
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it is a single-chain glycoprotein synthesized in the liver. It is a member of the class of protease inhibitor proteins known as serine protease inhibitors (serpins) [2]. Neutrophil elastase has a high potential to destroy the matrix components of the lungs. It is responsible for breaking down the elastin proteins and other components of the extracellular matrix which provides flexibility...
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doi:10.3906/kim-2010-34. Many etiopathogenic mechanisms including metabolic, genetic, environmental factors, and lifestyle are key pathological features in appearance and progression of the disease [2]. That is released at the end of the neuron by the appearance of a nerve impulse, which is transmitted at synapses. Enhancement of the activity of cholinergic neurons seems to be the only way to develop strong...
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In vitro effects of pesticide exposure on the activity of the paraoxonase-1 enzyme from sheep liver microsomes. They are also used as nerve gases, such as sarin and soman. Therefore, the effects of these compounds on enzymatic activity are well known. In the present study, we investigated the in vitro effects of fenoxaprop-p-ethyl, lambda cyhalothrin, imidacloprid, and dichlorvos pesticides on...
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Anesthesiology and cognitive impairment:. Furthermore, there is conflicting data on the relationship between anesthesia exposure and the development of long-term neurocognitive disorders, or development of incident dementia in the patient population with normal preoperative cognitive function. Main body: This review highlights landmark and recent studies in the field, and explores potential mechanisms involved in perioperative cognitive disorders (also known as...
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exacerbate plaque deposition or synapse loss in APP/PS1 Alzheimer ’ s disease mice. To mitigate many of the methodological issues encountered in human retrospective cohort studies we have used a transgenic model of AD to investigate the effect of propofol on AD pathology.. Results: There was no difference in the extent of β -amyloid (A β ) immunolabeled plaque deposition...
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cognitive training or stimulation and cognitive decline at the 2014 WDC meeting in London (Baumgart et al., 2015).. Nonpharmacological strategies may be based on physical activity, brain stimulation, social communication, and diet-chemical substances (Peng et al., 2016).. EE appears to affect AD-like pathology through multiple mechanical pathways, including hippocampal neurogenesis, amyloid plaques, glial pathology, formation neurotrophic factors, and AD-related factors...
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Objectives: To evaluate the effects of willughbela cochinchinessis (WC) to locomotor disorders in an Alzheimer's disease (AD) model of mice. Subjects and methods: 50 Swiss mice were separated randomly into 5 experimental groups, 10 mice for each group. Group 1: Mice were intraperitoneally injected (i.p) and orally administered (p.o) saline at dose 0.1 mL/10 g;. group 2: mice were injected...