Có 11+ tài liệu thuộc chủ đề "Postoperative cognitive dysfunction"
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MiR-190a potentially ameliorates postoperative cognitive dysfunction by regulating Tiam1. The aim of current study was to screen the POCD-related miRNAs in the hippocampus tissues and. Methods: The miRNA microarray was used to find the abnormal expression of miRNAs in the hippocampus tissues from the POCD model mice to normal mice (Discovery cohort, 3 vs 3). Among these miRNAs, mmu-miR-190a-3p was...
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Risk factors and predictive value of. perioperative neurocognitive disorders in elderly patients with gastrointestinal. Background: This study aims to investigate the risk factors of perioperative neurocognitive disorders (PNDs) mainly including postoperative cognitive dysfunction (POCD) in elderly patients with gastrointestinal tumors, and evaluate its predictive value.. Methods: A total of 222 eligible elderly patients. Receiver operating characteristic curve analysis was performed...
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Hundred most cited articles in. Through a retrospective bibliometric analysis, this study aims to identify and characterize the top 100 cited publications on PND.. Methods: We searched the Web of Science database to find the top 100 cited articles focusing on PND. Results: The top 100 cited articles were published between 1955 and 2016. the number of citations ranged from...
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hypotension and postoperative cognitive impairment: a meta-analysis of randomized controlled trials. Background: There is no consensus on whether intraoperative hypotension is associated with postoperative cognitive impairment. Hence, we performed a meta-analysis to evaluate the correlation of intraoperative hypotension and the incidence of postoperative delirium (POD) or postoperative cognitive dysfunction (POCD).. Methods: We searched PubMed, Embase, and Cochrane Library databases to...
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Anesthesiology and cognitive impairment:. Furthermore, there is conflicting data on the relationship between anesthesia exposure and the development of long-term neurocognitive disorders, or development of incident dementia in the patient population with normal preoperative cognitive function. Main body: This review highlights landmark and recent studies in the field, and explores potential mechanisms involved in perioperative cognitive disorders (also known as...
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Postoperative cognitive dysfunction after robot-assisted radical cystectomy (RARC) with cerebral oxygen monitoring an. Background: The incidence and risk factors of postoperative cognitive dysfunction (POCD) during robot-assisted radical cystectomy (RARC) in extreme Trendelenburg positioning and pneumoperitoneum are still controversial. The aim of this prospective observational study was to find the incidence rate as well as possible risk factors of POCD in...
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neuroinflammation through targeting of the gut-brain axis. Background: Surgery-induced neuroinflammation plays an important role in postoperative cognitive dysfunction (POCD). The aim of the present study was to test whether administration of the prebiotic Bimuno® (galactooligosaccharide (B-GOS) mixture) could ameliorate POCD and attenuate surgery-induced neuroinflammation through the microbiota-brain-axis.. Expression of microglial marker Iba-1 in the hippocampus was assessed by immunohistochemical staining....
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Risk factors for early postoperative cognitive dysfunction after colorectal surgery. Background: It has been reported that postoperative cognitive dysfunction (POCD) is correlated with the degeneration of the central nervous system, oxidative stress, inflammation, and endocrine and immune dysfunction. Increased age, predisposed comorbidity, long surgery time, and prolonged stay in the intensive care unit have been reported to be risk factors...
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High-fat diet aggravates postoperative cognitive dysfunction in aged mice. Although Sirt1 and apoptosis are significant responders to HFD in the brain, little is known regarding the functional correlations between HFD and POCD.. The expression levels of Sirt1, Bcl-2, Bax and caspase-3 cleaved were detected by western blot.. Results: The MWM and western blotting results showed that the learning and memory...
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calcineurin mediated hippocampal neuroapoptosis in aged rats. Pretreatment with nimodipine can lower the apoptosis rate of hippocampal neuron to reduce the incidence of postoperative cognitive dysfunction (POCD). However, the relationship between cerebral protective effect of pretreatment with nimodipine and CaN is controversial in the literature. The aim of this study is to evaluate the relationship between neuroprotective effect of nimodipine...
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Influence of the postoperative. inflammatory response on cognitive. decline in elderly patients undergoing on- pump cardiac surgery: a controlled,. Background: The role of non-infective inflammatory response (IR) in the aetiology of postoperative cognitive dysfunction (POCD) is still controversial. Results: The LIR ( n = 20) and HIR ( n = 22) groups differed significantly in the PCT ( p <....