Tìm thấy 19+ kết quả cho từ khóa "Aged rats"
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Our previous study have shown that pretreatment of nimodipine could inhibit calcium overload-induced apop- tosis in hippocampal neurons and improve the postopera- tive cognition of aged rats [20]. Our results further showed that pretreatment with nimodipine could reduce incidence of POCD by decreasing CaN mediated hippocampal neuroapoptosis in aged rats.. Therefore, our study choose Morris water maze test to evaluate the cogni- tion of aged rats..
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tissues of anesthetized aged rats.
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Background: This study aimed to evaluate effects of electric vagal nerve stimulation on early postoperation cognitive dysfunction in aged rats.. In SV group, vagal nerve stimulation decreased heart rate lower than 10% of basic level and kept it at a stable range by regulating stimulation intensity.. After stimulation stop, heart rate returned to the basic level again. This indicated that the model of vagal nerve stimulation was successful.
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Administration of Ta-65 to aged rats improved serum levels of testosterone, FSH, and LH compared to the aged group, but the levels were still significantly lower than the normal young levels by and 40.02%, respectively. to aged rats treated with Ta-65 but no significant change in serum testosterone level was reported between the two groups.. Oral administration of Ta-65 to aged rats. Young control Aged control Aged+Ta-65 Aged+Pomegranate.
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Results: The histological scores in aged rats were significantly lower than those in young rats. At the protein level, collagen synthesis-related markers Col-3, Matrix metalloproteinase-1 and Metallopeptidase Inhibitor 1(TIMP-1) were decreased at week 4 in aged rats compared with those of young rats.
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Endoplasmic reticulum stress pathway mediates isoflurane-induced neuroapoptosis and cognitive impairments in aged rats. Edaravone improves spatial memory and modulates endoplasmic reticulum stress-mediated apoptosis after abdominal surgery in mice. Homoharringtonine prevents surgery-induced epidural fibrosis through endoplasmic reticulum stress signaling pathway. Endoplasmic reticulum stress responses.
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In a related experiment, Carter and Lynch (1994c) studied the effect of clenbuterol on recovery of muscle mass and carcass protein content after protein malnutrition in aged rats. The addition of clen- buterol to the diet increased hindlimb muscle mass by 30% and protein content by 25%, in aged rats (Carter and Lynch 1994c).
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Effect of stellate ganglion block on reconstruc- tion of the left ventricle in spontaneously hypertensive rats. Effects of stellate ganglion block on blood pressure in spontaneously hypertensive rats. Effects of stellate ganglion block on AMP-ativated protein kinase and astrocyte in hip- pocampal neurons in postoperative aged rats. Effects of ultrasound- guided stellate ganglion block on cerebral oxygen metabolism and postoperative cognitive dysfunction in the elderly.
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Death receptor-associated pro-apoptotic signal- ing in aged skeletal muscle. Molecular regulation of apoptosis in fast plantaris muscles of aged rats. Interleukin-15 responses to aging and unloading- induced skeletal muscle atrophy. Apoptosis of myofibres and satellite cells: exercise-induced damage in skeletal muscle of the mouse. Apoptosis in mouse skeletal muscles after physical exercise. The role of apoptosis in the normal aging brain, skeletal muscle, and heart.
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The aforementioned results indicate that senescent skeletal muscle loses its abil- ity to generate new mitochondria in advanced age, suggesting that the reduced. 10 Muscle oxygen uptake during incremental muscle contractions in distal rat hindlimb muscles pump-perfused in situ (top) and the activity of complex IV in homogenates of plantaris (Plan) and gastrocnemius (Gas) muscle (bottom) in sedentary late middle aged rats and late middle aged rats exercise-trained for 7 weeks (Reproduced from Betik
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In aged rats Akt-1 activity is decreased with a concomitant increase in atrogin-1 and MuRF1 mRNA levels in the fast-twitch tibialis anterior muscle (Clavel et al.. In contrast, atrogin-1 and MuRF1 mRNA levels are reduced in the mixed- fibre gastrocnemius muscle in rats (Edstrom et al. at least in elderly men (Leger et al. Welle et al. Whitman et al.
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Postoperative cognitive dysfunction and microglial activation in associated brain regions in old rats. Erythropoietin attenuates postoperative cognitive dysfunction by shifting macrophage activation toward the M2 phenotype. Role of the gut microbiota in immunity and inflammatory disease. Surgery-induced behavioral changes in aged rats. Postoperative cognitive dysfunction and neuroinflammation.
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Slower regenera- tion and re-innervation in aged compared to young motor endplates was recorded in response to crush injury of the peripheral nerve (Kawabuchi et al. et al. The difference in the time needed to recover was attributed to a transient failure in the spatiotemporal relationship between Schwann cells, axons, and the postsynaptic acetylcholine receptor regions during re-innervation in aged rats (Kawabuchi et al.
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Neuroprotection of Dexmedetomidine against cerebral ischemia-reperfusion injury in rats:. Dexmedetomidine attenuated early brain injury in rats with subarachnoid haemorrhage by suppressing the inflammatory response: the TLR4/NF- κ B pathway and the NLRP3 inflammasome may be involved in the mechanism. Sevoflurane anesthesia alters cognitive function by activating inflammation and cell death in rats. Dexmedetomidine on autophagy of hippocampal neurons in aged rats under sevoflurane anesthesia.
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The glycation of myosin is detected in the skeletal muscle of aged rats (Syrovy and Hodny 1992). Thus, modification of lysine- rich nucleotide- and actin-binding regions of the myosin molecule is a possible mechanism for the functional loss..
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It has been reported that glucocorticoids that induce the ubiquitin-dependent muscle proteolysis in fasted or acidotic young rats, do not induce such proteolysis in aged rats (Dardevet et al. 7 Differences in protein turnover in cancer cachexia and muscle sarcopenia.
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A similar increase in lesions occurs in aged rats, but these are reduced with a concomitant increase in life span in rats maintained on a calorie restricted diet and further improved (30%) when coupled with suppression of the GH/IGF-1 axis via hemizygote expression of an antisense transgene for GH (Zha et al.
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Attenuated HSP70 response in skeletal Muscle of aged rats following contractile activity. Vasilaki, A., Csete, M., Pye, D., Lee, S., Palomero, J., McArdle, F., Van Remmen, H., Richardson, A., McArdle, A., Faulkner, J. Genetic modification of the manganese superoxide dismutase/glutathione peroxidase 1 pathway influences intracellular ROS genera- tion in quiescent, but not contracting, skeletal muscle cells. Vasilaki, A., McArdle, F., Iwanejko, L.
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Quantitative assessment of new cell proliferation in the dentate gyrus and learning after isoflurane or propofol anesthesia in young and aged rats. Loss of functional GABA(a) receptors in the Alzheimer diseased brain. Immunohistochemical study of GABAA receptor alpha1 subunit in the hippocampal formation of aged brains with Alzheimer-related neuropathologic changes.
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Changes in the glucose tolerance curve in three groups of rats. The results of the OGTT showed that the postpran- dial blood glucose of aged OLETF rats was significantly. higher than that of the control groups (P <. Effects of KCl (60 mM) on the contraction of aortic smooth muscle in three groups of rats. KCl (60 mM) induced rapid and continuous contrac- tion of aortic smooth muscle in the three groups.